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Volumn 38, Issue 11, 2013, Pages 3529-3539

Synaptic vesicle protein 2A: Basic facts and role in synaptic function

Author keywords

Epilepsy; Neurotransmitter; Neurotransmitter release; Synapse; Synaptic proteins

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM ION; ETIRACETAM; GLUTAMIC ACID; MEMBRANE PROTEIN; MICRORNA; MICRORNA 485; NEUROTRANSMITTER; PROTEOGLYCAN; SYNAPTIC VESICLE PROTEIN 2A; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

EID: 84897085781     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12360     Document Type: Review
Times cited : (96)

References (81)
  • 1
    • 0026786473 scopus 로고
    • SV2, a brain synaptic vesicle protein homologous to bacterial transporters
    • Bajjalieh, S.M., Peterson, K., Shinghal, R. & Scheller, R.H. (1992) SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science, 257, 1271-1273.
    • (1992) Science , vol.257 , pp. 1271-1273
    • Bajjalieh, S.M.1    Peterson, K.2    Shinghal, R.3    Scheller, R.H.4
  • 4
    • 0027848571 scopus 로고
    • Conservation of the amino acid sequence of SV2, a transmembrane transporter in synaptic vesicles and endocrine cells
    • Bindra, P.S., Knowles, R. & Buckley, K.M. (1993) Conservation of the amino acid sequence of SV2, a transmembrane transporter in synaptic vesicles and endocrine cells. Gene, 137, 299-302.
    • (1993) Gene , vol.137 , pp. 299-302
    • Bindra, P.S.1    Knowles, R.2    Buckley, K.M.3
  • 5
    • 4444366193 scopus 로고    scopus 로고
    • Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel
    • Bostick, D.L. & Berkowitz, M.L. (2004) Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel. Biophys. J., 87, 1686-1696.
    • (2004) Biophys. J. , vol.87 , pp. 1686-1696
    • Bostick, D.L.1    Berkowitz, M.L.2
  • 7
    • 33644770187 scopus 로고    scopus 로고
    • Structure and function of SNARE and SNARE-interacting proteins
    • Brunger, A.T. (2005) Structure and function of SNARE and SNARE-interacting proteins. Q. Rev. Biophys., 38, 1-47.
    • (2005) Q. Rev. Biophys. , vol.38 , pp. 1-47
    • Brunger, A.T.1
  • 8
    • 0021922503 scopus 로고
    • Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells
    • Buckley, K. & Kelly, R.B. (1985) Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells. J. Cell Biol., 100, 1284-1294.
    • (1985) J. Cell Biol. , vol.100 , pp. 1284-1294
    • Buckley, K.1    Kelly, R.B.2
  • 10
  • 12
    • 80755169688 scopus 로고    scopus 로고
    • Network bursts in hippocampal microcultures are terminated by exhaustion of vesicle pools
    • Cohen, D. & Segal, M. (2011) Network bursts in hippocampal microcultures are terminated by exhaustion of vesicle pools. J. Neurophysiol., 106, 2314-2321.
    • (2011) J. Neurophysiol. , vol.106 , pp. 2314-2321
    • Cohen, D.1    Segal, M.2
  • 14
    • 32544452985 scopus 로고    scopus 로고
    • Synaptic vesicle protein 2 enhances release probability at quiescent synapses
    • Custer, K.L., Austin, N.S., Sullivan, J.M. & Bajjalieh, S.M. (2006) Synaptic vesicle protein 2 enhances release probability at quiescent synapses. J. Neurosci., 26, 1303-1313.
    • (2006) J. Neurosci. , vol.26 , pp. 1303-1313
    • Custer, K.L.1    Austin, N.S.2    Sullivan, J.M.3    Bajjalieh, S.M.4
  • 17
    • 58549094719 scopus 로고    scopus 로고
    • Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons
    • Dong, M., Liu, H., Tepp, W.H., Johnson, E.A., Janz, R. & Chapman, E.R. (2008) Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Mol. Biol. Cell, 19, 5226-5237.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5226-5237
    • Dong, M.1    Liu, H.2    Tepp, W.H.3    Johnson, E.A.4    Janz, R.5    Chapman, E.R.6
  • 19
    • 0035478585 scopus 로고    scopus 로고
    • Macromolecular crowding: obvious but underappreciated
    • Ellis, R.J. (2001) Macromolecular crowding: obvious but underappreciated. Trends Biochem. Sci., 26, 597-604.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 597-604
    • Ellis, R.J.1
  • 20
    • 0026726318 scopus 로고
    • The synaptic vesicle protein SV2 is a novel type of transmembrane transporter
    • Feany, M.B., Lee, S., Edwards, R.H. & Buckley, K.M. (1992) The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell, 70, 861-867.
    • (1992) Cell , vol.70 , pp. 861-867
    • Feany, M.B.1    Lee, S.2    Edwards, R.H.3    Buckley, K.M.4
  • 21
    • 73849149840 scopus 로고    scopus 로고
    • Down-regulation of synaptic vesicle protein 2A in the anterior temporal neocortex of patients with intractable epilepsy
    • Feng, G., Xiao, F., Lu, Y., Huang, Z., Yuan, J., Xiao, Z., Xi, Z. & Wang, X. (2009) Down-regulation of synaptic vesicle protein 2A in the anterior temporal neocortex of patients with intractable epilepsy. J. Mol. Neurosci., 39, 354-359.
    • (2009) J. Mol. Neurosci. , vol.39 , pp. 354-359
    • Feng, G.1    Xiao, F.2    Lu, Y.3    Huang, Z.4    Yuan, J.5    Xiao, Z.6    Xi, Z.7    Wang, X.8
  • 22
    • 84897047725 scopus 로고    scopus 로고
    • GeneCards, Available
    • GeneCards (2013) Available http://www.genecards.org.
    • (2013)
  • 23
    • 33645813802 scopus 로고    scopus 로고
    • Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein
    • Gillard, M., Chatelain, P. & Fuks, B. (2006) Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Eur. J. Pharmacol., 536, 102-108.
    • (2006) Eur. J. Pharmacol. , vol.536 , pp. 102-108
    • Gillard, M.1    Chatelain, P.2    Fuks, B.3
  • 24
    • 0026471768 scopus 로고
    • Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system
    • Gingrich, J.A., Andersen, P.H., Tiberi, M., el Mestikawy, S., Jorgensen, P.N., Fremeau, R.T. Jr. & Caron, M.G. (1992) Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system. FEBS Lett., 312, 115-122.
    • (1992) FEBS Lett. , vol.312 , pp. 115-122
    • Gingrich, J.A.1    Andersen, P.H.2    Tiberi, M.3    El Mestikawy, S.4    Jorgensen, P.N.5    Fremeau Jr, R.T.6    Caron, M.G.7
  • 26
    • 74849093404 scopus 로고    scopus 로고
    • Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein
    • Gronborg, M., Pavlos, N.J., Brunk, I., Chua, J.J., Münster-Wandowski, A., Riedel, D., Ahnert-Hilger, G., Urlaub, H. & Jahn, R. (2010) Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. J. Neurosci., 60, 2-12.
    • (2010) J. Neurosci. , vol.60 , pp. 2-12
    • Gronborg, M.1    Pavlos, N.J.2    Brunk, I.3    Chua, J.J.4    Münster-Wandowski, A.5    Riedel, D.6    Ahnert-Hilger, G.7    Urlaub, H.8    Jahn, R.9
  • 27
    • 77952315692 scopus 로고    scopus 로고
    • Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex
    • de Groot, M., Toering, S.T., Boer, K., Spliet, W.G., Heimans, J.J., Aronica, E. & Reijneveld, J.C. (2010) Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex. Neuro-Oncology, 12, 265-273.
    • (2010) Neuro-Oncology , vol.12 , pp. 265-273
    • de Groot, M.1    Toering, S.T.2    Boer, K.3    Spliet, W.G.4    Heimans, J.J.5    Aronica, E.6    Reijneveld, J.C.7
  • 28
    • 80053312809 scopus 로고    scopus 로고
    • Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma
    • de Groot, M., Aronica, E., Heimans, J.J. & Reijneveld, J.C. (2011) Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. Neurology, 77, 532-539.
    • (2011) Neurology , vol.77 , pp. 532-539
    • de Groot, M.1    Aronica, E.2    Heimans, J.J.3    Reijneveld, J.C.4
  • 29
    • 84864366265 scopus 로고    scopus 로고
    • Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure
    • Hanaya, R., Hosoyama, H., Sugata, S., Tokudome, M., Hirano, H., Tokimura, H., Kurisu, K., Serikawa, T., Sasa, M. & Arita, K. (2012) Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure. Neuroscience, 221, 12-20.
    • (2012) Neuroscience , vol.221 , pp. 12-20
    • Hanaya, R.1    Hosoyama, H.2    Sugata, S.3    Tokudome, M.4    Hirano, H.5    Tokimura, H.6    Kurisu, K.7    Serikawa, T.8    Sasa, M.9    Arita, K.10
  • 30
    • 34447256364 scopus 로고    scopus 로고
    • Conformational change in an MFS protein: MD simulations of LacY
    • Holyoake, J. & Sansom, M.S. (2007) Conformational change in an MFS protein: MD simulations of LacY. Structure, 15, 873-884.
    • (2007) Structure , vol.15 , pp. 873-884
    • Holyoake, J.1    Sansom, M.S.2
  • 32
    • 0344761960 scopus 로고    scopus 로고
    • SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family
    • Janz, R. & Sudhof, T.C. (1999) SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family. Neuroscience, 94, 1279-1290.
    • (1999) Neuroscience , vol.94 , pp. 1279-1290
    • Janz, R.1    Sudhof, T.C.2
  • 34
    • 67649992215 scopus 로고    scopus 로고
    • Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam
    • Kaminski, R.M., Gillard, M., Leclercq, K., Hanon, E., Lorent, G., Dassesse, D., Matagne, A. & Klitgaard, H. (2009) Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam. Epilepsia, 50, 1729-1740.
    • (2009) Epilepsia , vol.50 , pp. 1729-1740
    • Kaminski, R.M.1    Gillard, M.2    Leclercq, K.3    Hanon, E.4    Lorent, G.5    Dassesse, D.6    Matagne, A.7    Klitgaard, H.8
  • 35
    • 84865612418 scopus 로고    scopus 로고
    • Targeting SV2A for discovery of antiepileptic drugs
    • In Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W. & Delgado-Escueta, A.V. (Eds), Jasper's Basic Mechanisms of the Epilepsies [Internet], 4th edition. Bethesda (MD), National Center for Biotechnology Information (US). Available
    • Kaminski, R.M., Gillard, M. & Klitgaard, H. (2012) Targeting SV2A for discovery of antiepileptic drugs. In Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W. & Delgado-Escueta, A.V. (Eds), Jasper's Basic Mechanisms of the Epilepsies [Internet], 4th edition. Bethesda (MD), National Center for Biotechnology Information (US). Available http://www.ncbi.nlm.nih.gov/books/NBK98183/.
    • (2012)
    • Kaminski, R.M.1    Gillard, M.2    Klitgaard, H.3
  • 36
    • 0032582643 scopus 로고    scopus 로고
    • Tryptophan 388 in putative transmembrane segment 10 of the rat glucose transporter Glut1 is essential for glucose transport
    • Kasahara, T. & Kasahara, M. (1998) Tryptophan 388 in putative transmembrane segment 10 of the rat glucose transporter Glut1 is essential for glucose transport. J. Biol. Chem., 273, 29113-29117.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29113-29117
    • Kasahara, T.1    Kasahara, M.2
  • 38
    • 84867414968 scopus 로고    scopus 로고
    • Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles
    • Kwon, S.E. & Chapman, E.R. (2012) Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. J. Biol. Chem., 287, 35658-35668.
    • (2012) J. Biol. Chem. , vol.287 , pp. 35658-35668
    • Kwon, S.E.1    Chapman, E.R.2
  • 40
    • 2342558309 scopus 로고
    • Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum
    • Leberer, E., Charuk, J.H., Green, N.M. & MacLennan, D.H. (1989) Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. Proc. Natl. Acad. Sci. USA, 86, 6047-6051.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6047-6051
    • Leberer, E.1    Charuk, J.H.2    Green, N.M.3    MacLennan, D.H.4
  • 41
    • 0023879324 scopus 로고
    • Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common
    • Lowe, A.W., Madeddu, L. & Kelly, R.B. (1988) Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common. J. Cell Biol., 106, 51-59.
    • (1988) J. Cell Biol. , vol.106 , pp. 51-59
    • Lowe, A.W.1    Madeddu, L.2    Kelly, R.B.3
  • 45
    • 79952554789 scopus 로고    scopus 로고
    • Levetiracetam: a review of its use in epilepsy
    • Lyseng-Williamson, K.A. (2011) Levetiracetam: a review of its use in epilepsy. Drugs, 71, 489-514.
    • (2011) Drugs , vol.71 , pp. 489-514
    • Lyseng-Williamson, K.A.1
  • 46
    • 0028784616 scopus 로고
    • ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo
    • Margineanu, D.G. & Wulfert, E. (1995) ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo. Eur. J. Pharmacol., 286, 321-325.
    • (1995) Eur. J. Pharmacol. , vol.286 , pp. 321-325
    • Margineanu, D.G.1    Wulfert, E.2
  • 47
    • 54849412682 scopus 로고    scopus 로고
    • Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue
    • Maritzen, T., Keating, D.J., Neagoe, I., Zdebik, A.A. & Jentsch, T.J. (2008) Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue. J. Neurosci., 28, 10587-10598.
    • (2008) J. Neurosci. , vol.28 , pp. 10587-10598
    • Maritzen, T.1    Keating, D.J.2    Neagoe, I.3    Zdebik, A.A.4    Jentsch, T.J.5
  • 49
    • 33847188536 scopus 로고    scopus 로고
    • Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm
    • Matveeva, E.A., Vanaman, T.C., Whiteheart, S.W. & Slevin, J.T. (2007) Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm. Epilepsy Res., 73, 266-274.
    • (2007) Epilepsy Res. , vol.73 , pp. 266-274
    • Matveeva, E.A.1    Vanaman, T.C.2    Whiteheart, S.W.3    Slevin, J.T.4
  • 50
    • 80052562796 scopus 로고    scopus 로고
    • A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam
    • Meehan, A.L., Yang, X., McAdams, B.D., Yuan, L. & Rothman, S.M. (2011) A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J. Neurophysiol., 106, 1227-1239.
    • (2011) J. Neurophysiol. , vol.106 , pp. 1227-1239
    • Meehan, A.L.1    Yang, X.2    McAdams, B.D.3    Yuan, L.4    Rothman, S.M.5
  • 51
    • 84862803683 scopus 로고    scopus 로고
    • Levetiracetam has an activity-dependent effect on inhibitory transmission
    • Meehan, A.L., Yang, X., Yuan, L.L. & Rothman, S.M. (2012) Levetiracetam has an activity-dependent effect on inhibitory transmission. Epilepsia, 53, 469-476.
    • (2012) Epilepsia , vol.53 , pp. 469-476
    • Meehan, A.L.1    Yang, X.2    Yuan, L.L.3    Rothman, S.M.4
  • 52
    • 0013657423 scopus 로고
    • Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells
    • Neher, E. & Marty, A. (1982) Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA, 79, 6712-6716.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6712-6716
    • Neher, E.1    Marty, A.2
  • 55
    • 70449716878 scopus 로고    scopus 로고
    • Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling
    • Ohno, Y., Ishihara, S., Terada, R., Kikuta, M., Sofue, N., Kawai, Y., Serikawa, T. & Sasa, M. (2009) Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Biochem. Bioph. Res. Co., 390, 415-420.
    • (2009) Biochem. Bioph. Res. Co. , vol.390 , pp. 415-420
    • Ohno, Y.1    Ishihara, S.2    Terada, R.3    Kikuta, M.4    Sofue, N.5    Kawai, Y.6    Serikawa, T.7    Sasa, M.8
  • 56
    • 84856783452 scopus 로고    scopus 로고
    • Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus
    • Ohno, Y., Okumura, T., Terada, R., Ishihara, S., Serikawa, T. & Sasa, M. (2012) Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus. Neurosci. Lett., 510, 93-98.
    • (2012) Neurosci. Lett. , vol.510 , pp. 93-98
    • Ohno, Y.1    Okumura, T.2    Terada, R.3    Ishihara, S.4    Serikawa, T.5    Sasa, M.6
  • 57
    • 33846010171 scopus 로고    scopus 로고
    • A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport
    • Perry, J.L., Dembla-Rajpal, N., Hall, L.A. & Pritchard, J.B. (2006) A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J. Biol. Chem., 281, 38071-38079.
    • (2006) J. Biol. Chem. , vol.281 , pp. 38071-38079
    • Perry, J.L.1    Dembla-Rajpal, N.2    Hall, L.A.3    Pritchard, J.B.4
  • 58
    • 84897030297 scopus 로고    scopus 로고
    • PhosphoSite, Available
    • PhosphoSite (2013) Available http://www.phosphosite.org.
    • (2013)
  • 59
    • 0034595646 scopus 로고    scopus 로고
    • Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin
    • Pyle, R.A., Schivell, A.E., Hidaka, H. & Bajjalieh, S.M. (2000) Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin. J. Biol. Chem., 275, 17195-17200.
    • (2000) J. Biol. Chem. , vol.275 , pp. 17195-17200
    • Pyle, R.A.1    Schivell, A.E.2    Hidaka, H.3    Bajjalieh, S.M.4
  • 60
    • 33746115639 scopus 로고    scopus 로고
    • Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study
    • Ramael, S., Daoust, A., Otoul, C., Toublanc, N., Troenaru, M., Lu, Z.S. & Stockis, A. (2006) Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia, 47, 1128-1135.
    • (2006) Epilepsia , vol.47 , pp. 1128-1135
    • Ramael, S.1    Daoust, A.2    Otoul, C.3    Toublanc, N.4    Troenaru, M.5    Lu, Z.S.6    Stockis, A.7
  • 62
    • 79953206228 scopus 로고    scopus 로고
    • Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
    • Riazanski, V., Deriy, L.V., Shevchenko, P.D., Le, B., Gomez, E.A. & Nelson, D.J. (2011) Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus. Nat. Neurosci., 14, 487-494.
    • (2011) Nat. Neurosci. , vol.14 , pp. 487-494
    • Riazanski, V.1    Deriy, L.V.2    Shevchenko, P.D.3    Le, B.4    Gomez, E.A.5    Nelson, D.J.6
  • 64
    • 58849125253 scopus 로고    scopus 로고
    • A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles
    • Schenck, S., Wojcik, S.M., Brose, N. & Takamori, S. (2009) A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles. Nat. Neurosci., 12, 156-162.
    • (2009) Nat. Neurosci. , vol.12 , pp. 156-162
    • Schenck, S.1    Wojcik, S.M.2    Brose, N.3    Takamori, S.4
  • 65
    • 0029861418 scopus 로고    scopus 로고
    • Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin
    • Schivell, A.E., Batchelor, R.H. & Bajjalieh, S.M. (1996) Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. J. Biol. Chem., 271, 27770-27775.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27770-27775
    • Schivell, A.E.1    Batchelor, R.H.2    Bajjalieh, S.M.3
  • 67
    • 80053381169 scopus 로고    scopus 로고
    • Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding
    • Shi, J., Anderson, D., Lynch, B.A., Castaigne, J.G., Foerch, P. & Lebon, F. (2011) Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding. Biochem. Soc. T., 39, 1341-1347.
    • (2011) Biochem. Soc. T. , vol.39 , pp. 1341-1347
    • Shi, J.1    Anderson, D.2    Lynch, B.A.3    Castaigne, J.G.4    Foerch, P.5    Lebon, F.6
  • 68
    • 78650616483 scopus 로고    scopus 로고
    • Assessment of levetiracetam bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy: open-label, single-dose, randomized, four-way crossover study in healthy male volunteers
    • Stockis, A., Sargentini-Maier, M.L., Otoul, C., Connor, A., Wilding, I. & Wray, H. (2010) Assessment of levetiracetam bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy: open-label, single-dose, randomized, four-way crossover study in healthy male volunteers. Clin. Ther., 32, 1813-1821.
    • (2010) Clin. Ther. , vol.32 , pp. 1813-1821
    • Stockis, A.1    Sargentini-Maier, M.L.2    Otoul, C.3    Connor, A.4    Wilding, I.5    Wray, H.6
  • 70
    • 84993724882 scopus 로고    scopus 로고
    • Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited
    • Surges, R., Volynski, K.E. & Walker, M.C. (2008) Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther. Adv. Neurol. Disord., 1, 13-24.
    • (2008) Ther. Adv. Neurol. Disord. , vol.1 , pp. 13-24
    • Surges, R.1    Volynski, K.E.2    Walker, M.C.3
  • 72
    • 70449727382 scopus 로고    scopus 로고
    • Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures
    • Ulloa, C.M., Towfigh, A. & Safdieh, J. (2009) Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures. Neuropsychiatr. Dis. Treat., 5, 467-476.
    • (2009) Neuropsychiatr. Dis. Treat. , vol.5 , pp. 467-476
    • Ulloa, C.M.1    Towfigh, A.2    Safdieh, J.3
  • 73
    • 84897055959 scopus 로고    scopus 로고
    • UniProt Consortium, UniProt Consortium/SV2A/Q02563.
    • UniProt Consortium (2013) UniProt Consortium/SV2A/Q02563.
    • (2013)
  • 74
    • 63049140024 scopus 로고    scopus 로고
    • SV2 frustrating exocytosis at the semi-diffusor synapse
    • Vautrin, J. (2009) SV2 frustrating exocytosis at the semi-diffusor synapse. Synapse, 63, 319-338.
    • (2009) Synapse , vol.63 , pp. 319-338
    • Vautrin, J.1
  • 75
    • 84867743271 scopus 로고    scopus 로고
    • Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice
    • Venkatesan, K., Alix, P., Marquet, A., Doupagne, M., Niespodziany, I., Rogister, B. & Seutin, V. (2012) Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice. J. Neurosci. Res., 90, 2317-2327.
    • (2012) J. Neurosci. Res. , vol.90 , pp. 2317-2327
    • Venkatesan, K.1    Alix, P.2    Marquet, A.3    Doupagne, M.4    Niespodziany, I.5    Rogister, B.6    Seutin, V.7
  • 76
    • 61849097125 scopus 로고    scopus 로고
    • Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy
    • van Vliet, E.A., Aronica, E., Redeker, S., Boer, K. & Gorter, J.A. (2009) Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy. Epilepsia, 50, 422-433.
    • (2009) Epilepsia , vol.50 , pp. 422-433
    • van Vliet, E.A.1    Aronica, E.2    Redeker, S.3    Boer, K.4    Gorter, J.A.5
  • 78
    • 0034908225 scopus 로고    scopus 로고
    • SV2 modulates the size of the readily releasable pool of secretory vesicles
    • Xu, T. & Bajjalieh, S.M. (2001) SV2 modulates the size of the readily releasable pool of secretory vesicles. Nat. Cell Biol., 3, 691-698.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 691-698
    • Xu, T.1    Bajjalieh, S.M.2
  • 79
    • 51049092758 scopus 로고    scopus 로고
    • Synaptic vesicle protein 2 binds adenine nucleotides
    • Yao, J. & Bajjalieh, S.M. (2008) Synaptic vesicle protein 2 binds adenine nucleotides. J. Biol. Chem., 283, 20628-20634.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20628-20634
    • Yao, J.1    Bajjalieh, S.M.2
  • 81
    • 0028168590 scopus 로고
    • Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
    • Zhang, J.Z., Davletov, B.A., Sudhof, T.C. & Anderson, R.G. (1994) Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling. Cell, 78, 751-760.
    • (1994) Cell , vol.78 , pp. 751-760
    • Zhang, J.Z.1    Davletov, B.A.2    Sudhof, T.C.3    Anderson, R.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.