MAPK-PPARα/γ signal transduction pathways are involved in Chlamydia pneumoniae-induced macrophage-derived foam cell formation

Microbial Pathogenesis

Volumn 69-70, Issue 1, 2014, Pages 1-8

  Cheng, Bei ^a   Wu, Xiaohua ^a   Sun, Shan ^a   Wu, Qinqin ^a   Mei, Chunli ^a   Xu, Qiumei ^a   Wu, Jianping ^a   He, Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Atherosclerosis; Chlamydia pneumoniae; Foam cells; Mitogen activated protein kinase; Peroxisome proliferator activated receptors

Indexed keywords

FAT DROPLET; JANUS KINASE 1; JANUS KINASE 2; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ARTICLE; CELL MIGRATION; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DOWN REGULATION; FOAM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPID STORAGE; MACROPHAGE; MOLECULAR INTERACTION; NONHUMAN; PPARALPHA GENE; PPARGAMMA GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL LINE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY;

CELL LINE; CHLAMYDOPHILA PNEUMONIAE; FOAM CELLS; HUMANS; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PPAR ALPHA; PPAR GAMMA; SIGNAL TRANSDUCTION;

EID: 84897064885     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2014.03.001     Document Type: Article

References (32)

1. Xu Q. Infections, heat shock proteins, and atherosclerosis. Curr Opin Cardiol 2003, 18:245-252.
2. Wolf K., Fischer E., Hackstadt T. Ultrastructural analysis of developmental events in Chlamydia pneumoniae-infected cells. Infect Immun 2000, 68:2379-2385.
3. Saikku P., Leinonen M., Mattila K., Ekman M.R., Nieminen M.S., Makela P.H., et al. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet 1988, 2:983-986.
4. Liu C., Waters D.D. Chlamydia pneumoniae and atherosclerosis: from Koch postulates to clinical trials. Prog Cardiovasc Dis 2005, 47:230-239.
5. Sessa R., Nicoletti M., Di Pietro M., Schiavoni G., Santino I., Zagaglia C., et al. Chlamydia pneumoniae and atherosclerosis: current state and future prospectives. Int J Immunopathol Pharmacol 2009, 22:9-14.
6. Kalayoglu M.V., Byrne G.I. Induction of macrophage foam cell formation by Chlamydia pneumoniae. JInfect Dis 1998, 177:725-729.
7. Barbier O., Torra I.P., Duguay Y., Blanquart C., Fruchart J.C., Glineur C., et al. Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 2002, 22:717-726.
8. Babaev V.R., Ishiguro H., Ding L., Yancey P.G., Dove D.E., Kovacs W.J., et al. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2007, 116:1404-1412.
9. Li A.C., Brown K.K., Silvestre M.J., Willson T.M., Palinski W., Glass C.K. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. JClin Invest 2000, 106:523-531.
10. Bai Z., Cheng B., Yu Q., Li C., He P., Mao X. Effects of leptin on expression of acyl-coenzymea: cholesterol acyltransferases-1 in cultured human monocyte-macrophages. JHuazhong Univ Sci Technol Med Sci 2004, 24:563-565. 90.
11. He P., Mei C., Cheng B., Liu W., Wang Y., Wan J. Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1. Microbes Infect 2009, 11:157-163.
12. Mei C.L., He P., Cheng B., Liu W., Wang Y.F., Wan J.J. Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol Int 2009, 33:301-308.
13. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
14. Krull M., Kramp J., Petrov T., Klucken A.C., Hocke A.C., Walter C., et al. Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells. Infect Immun 2004, 72:6615-6621.
15. Kim T.B., Moon K.A., Lee K.Y., Park C.S., Bae Y.J., Moon H.B., et al. Chlamydophila pneumoniae triggers release of CCL20 and vascular endothelial growth factor from human bronchial epithelial cells through enhanced intracellular oxidative stress and MAPK activation. JClin Immunol 2009, 29:629-636.
16. Kitazawa T., Fukushima A., Okugawa S., Yanagimoto S., Tsukada K., Tatsuno K., et al. Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Microbes Infect 2007, 9:1410-1414.
17. Liu W., He P., Cheng B., Mei C.L., Wang Y.F., Wan J.J. Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARgamma dependent signal transduction pathways. Microbes Infect 2010, 12:1226-1235.
18. Wang C.B., Feng Y.M., Zong Y.Q., Deng Y.Z., Feng Z.C. Rapid isolation of large amount of plasma VLDL and LDL by a two step ultracentrifugation. JTongji Med Univ 1995, 15:198-200.
19. Roblin P.M., Dumornay W., Hammerschlag M.R. Use of HEp-2 cells for improved isolation and passage of Chlamydia pneumoniae. JClin Microbiol 1992, 30:1968-1971.
20. Schaffner T., Taylor K., Bartucci E.J., Fischer-Dzoga K., Beeson J.H., Glagov S., et al. Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages. Am J Pathol 1980, 100:57-80.
21. Harnett M.M., Katz E., Ford C.A. Differential signalling during B-cell maturation. Immunol Lett 2005, 98:33-44.
22. Moraes L.A., Piqueras L., Bishop-Bailey D. Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 2006, 110:371-385.
23. Eder K., Guan H., Sung H.Y., Francis S.E., Crossman D.C., Kiss-Toth E. LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression. Immunol Lett 2008, 116:178-183.
24. Han C.J., Liu J.T., Li M., Cui M., Pang X.M., Mao J.J., et al. Rosiglitazone inhibits angiotensin II-induced C-reactive protein production in human aortic endothelial cells through regulating AT(1)-ROS-MAPK signal pathway. Inflamm Res 2012, 61:1031-1037.
25. Appel S., Mirakaj V., Bringmann A., Weck M.M., Grunebach F., Brossart P. PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. Blood 2005, 106:3888-3894.
26. Hou X., Shen Y.H., Li C., Wang F., Zhang C., Bu P., et al. PPARalpha agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity. Biochem Biophys Res Commun 2010, 394:653-659.
27. Liang H., Kowalczyk P., Junco J.J., Klug-De Santiago H.L., Malik G., Wei S.J., et al. Differential effects on lung cancer cell proliferation by agonists of glucocorticoid and PPARalpha receptors. Mol Carcinog 2013 Apr 26, [Epub ahead of print]. 10.1002/mc.22029.
28. Adams M., Reginato M.J., Shao D., Lazar M.A., Chatterjee V.K. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. JBiol Chem 1997, 272:5128-5132.
29. el Azzouzi H., Leptidis S., Bourajjaj M., van Bilsen M., da Costa Martins P.A., De Windt L.J. MEK1 inhibits cardiac PPARalpha activity by direct interaction and prevents its nuclear localization. PLoS ONE 2012, 7:e36799.
30. Camp H.S., Tafuri S.R., Leff T. c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity. Endocrinology 1999, 140:392-397.
31. Yin R., Dong Y.G., Li H.L. PPARgamma phosphorylation mediated by JNK MAPK: a potential role in macrophage-derived foam cell formation. Acta Pharmacol Sin 2006, 27:1146-1152.
32. Joly E., Roduit R., Peyot M.L., Habinowski S.A., Ruderman N.B., Witters L.A., et al. Glucose represses PPARalpha gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic beta-cell. JDiabetes 2009, 1:263-272.