Cell therapy for type 1 diabetes

QJM: An International Journal of Medicine

Volumn 107, Issue 4, 2014, Pages 253-259

  Muir, K R ^a   Lima, M J ^a   Docherty, H M ^a   Docherty, K ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACINAR CELL; CELL DIFFERENTIATION; CELL THERAPY; CELL TRANSDIFFERENTIATION; CELL TYPE; EMBRYONIC STEM CELL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; CELL TRANSPLANTATION; DIABETES MELLITUS, TYPE 1; PROCEDURES; TRANSPLANTATION; TRENDS;

CELL TRANSPLANTATION; DIABETES MELLITUS, TYPE 1; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION;

EID: 84897061262     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcu025     Document Type: Review

References (40)

1. Roth J, Qureshi S, Whitford I, Vranic M, Kahn CR, Fantus IG, et al. Insulin's discovery: new insights on its ninetieth birthday. Diabetes Metab Res Rev 2012;28:293-304.
2. Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM. Sequence of the human insulin gene. Nature 1980;284:26-32.
3. Thrower SL, Bingley PJ. Prevention of type 1 diabetes. Br Med Bull 2011;99:73-88.
4. Skyler JS. Primary and secondary prevention of Type 1 diabetes. Diabet Med 2013;30:161-9.
5. McCall M, Shapiro AM. Update on islet transplantation. Cold Spring Harb Perspect Med 2012;2:a007823.
6. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-8.
7. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-6.
8. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A 1981;78:7634-8.
9. Brons IG, Smithers LE, Trotter MW, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM, et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007;448:191-5.
10. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
11. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
12. Lensch MW, Mummery CL. From stealing fire to cellular reprogramming: a scientific history leading to the 2012 Nobel Prize. Stem Cell Rep 2013;1:5-17.
13. Campbell PM, Salam A, Ryan EA, Senior P, Paty BW, Bigam D, et al. Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation. Am J Transplant 2007;7:1242-8.
14. Turner M, Leslie S, Martin NG, Peschanski M, Rao M, Taylor CJ, et al. Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell 2013;13:382-4.
15. Rao M. iPSC crowdsourcing: a model for obtaining large panels of stem cell lines for screening. Cell Stem Cell 2013;13:389-91.
16. Panopoulos AD, Ruiz S, Izpisua Belmonte JC. iPSCs: induced back to controversy. Cell Stem Cell 2011;8:347-8.
17. Cahan P, Daley GQ. Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol 2013;14:357-68.
18. Bernardo AS, Hay CW, Docherty K. Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell. Mol Cell Endocrinol 2008;294:1-9.
19. Cho CH, Hannan NR, Docherty FM, Docherty HM, Joao Lima M, Trotter MW, et al. Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells. Diabetologia 2012;55:3284-95.
20. Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, et al. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes 2012;61:2016-29.
21. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008;26:443-52.
22. Yakhnenko I, Wong WK, Katkov II, Itkin-Ansari P. Cryopreservation of human insulin expressing cells macroencapsulated in a durable therapeutic immunoisolating device theracyte. Cryo Lett 2012;33:518-31.
23. Bruin JE, Rezania A, Xu J, Narayan K, Fox JK, O'Neil JJ, et al. Maturation and function of human embryonic stem cellderived pancreatic progenitors in macroencapsulation devices following transplant into mice. Diabetologia 2013;56:1987-98.
24. Graf T. Historical origins of transdifferentiation and reprogramming. Cell Stem Cell 2011;9:504-16.
25. Rooman I, Heremans Y, Heimberg H, Bouwens L. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro 1. Diabetologia 2000;43:907-14.
26. Horb ME, Shen CN, Tosh D, Slack JM. Experimental conversion of liver to pancreas. Curr Biol 2003;13:105-15.
27. Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568-72.
28. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to betacells. Nature 2008;455:627-32.
29. Campbell PM, Senior PA, Salam A, Labranche K, Bigam DL, Kneteman NM, et al. High risk of sensitization after failed islet transplantation. Am J Transplant 2007;7:2311-7.
30. Beattie GM, Cirulli V, Lopez AD, Hayek A. Ex vivo expansion of human pancreatic endocrine cells. J Clin Endocrinol Metab 1997;82:1852-6.
31. Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004;306:2261-4.
32. Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human beta-cells revealed by celllineage tracing. Diabetes 2008;57:1575-83.
33. Lima MJ, Muir KR, Docherty HM, Drummond R, McGowan NW, Forbes S, et al. Suppression of epithelialto-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells. Diabetes 2013;62:2821-33.
34. Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, Glandt M, et al. Expansion and redifferentiation of adult human pancreatic islet cells. Biochem Biophys Res Commun 2006;341:291-8.
35. Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, et al. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes 2007;56:703-8.
36. Efrat S, Russ HA. Making b cells from adult tissues. Trends Endocrinol Metab 2012;23:278-85.
37. Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, Warnock GL, et al. Production of functional glucagon-secreting alpha-cells from human embryonic stem cells. Diabetes 2011;60:239-47.
38. Bakhtiani PA, Zhao LM, El Youssef J, Castle JR, Ward WK. A review of artificial pancreas technologies with an emphasis on bi-hormonal therapy. Diabetes Obes Metab 2013;15:1065-70.
39. Shapiro AM. State of the art of clinical islet transplantation and novel protocols of immunosuppression. Curr Diab Rep 2011;11:345-54.
40. Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, et al. Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A 2013;110:19054-8.