Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis

Shock

Volumn 41, Issue 4, 2014, Pages 292-300

  Slinko, Siarhei ^a   Piraino, Giovanna ^a   Hake, Paul W ^a   Ledford, John R ^a   O'Connor, Michael ^a   Lahni, Patrick ^a   Solan, Patrick D ^b   Wong, Hector R ^a   Zingarelli, Basilia ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

C peptide; Extracellular signalYregulated kinases 1 and 2 (ERK1 2); Nuclear factor B (NF B); Zinc

Indexed keywords

C PEPTIDE; GLUCONATE ZINC; IMIPENEM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CLEARANCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INFLAMMATION; LIVER FUNCTION; LIVER INJURY; LUNG; MALE; MORTALITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; PROTEIN EXPRESSION; SEPSIS; SURVIVAL RATE; VITAMIN SUPPLEMENTATION; ACUTE LUNG INJURY; ANIMAL; BACTERIAL LOAD; BLOOD; C57BL MOUSE; COMPLICATION; CYTOLOGY; DIET SUPPLEMENTATION; DRUG COMBINATION; DRUG EFFECTS; DRUG SCREENING; LIVER DISEASES; LUNG LAVAGE; METABOLISM; MICROBIOLOGY; PROCEDURES; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ACUTE LUNG INJURY; ANIMALS; BACTERIAL LOAD; BRONCHOALVEOLAR LAVAGE FLUID; C-PEPTIDE; CYTOKINES; DIETARY SUPPLEMENTS; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NF-KAPPA B; SEPSIS; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ZINC;

EID: 84897051638     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000127     Document Type: Article

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