Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-xl binding to Bim

Marine Drugs

Volumn 12, Issue 3, 2014, Pages 1335-1348

  Cheng, Chunwei ^a   Liu, Yan ^b,c   Balasis, Maria E ^b   Simmons, Nicholas L ^d   Li, Jerry ^b   Song, Hao ^a   Pan, Lili ^a   Qin, Yong ^a,e   Nicolaou, K C ^d,f   Sebti, Said M ^b,g   Li, Rongshi ^b,c,g  

^a SICHUAN UNIVERSITY   (China)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e CHONGQING UNIVERSITY   (China)

^f RICE UNIVERSITY   (United States)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Apoptosis; Cyclic marinopyrroles; Protein protein interaction disruptors; SAR

Indexed keywords

3 HYDROXY 4 (2,3,7 TRICHLORO 13 OXO 10 (DIETHYLPHOSPHONYL) 1,13 DIHYDROBENZO[G]DIPYRROLO[2,1 B: 3',2' D][1,3]OXAZOCINE 5 CARBONYL)DIETHYL PHOSPHONATE; 3 HYDROXY 4 (2,3,7 TRICHLORO 13 OXO 10 PHOSPHORYL 1,13 DIHYDROBENZO[G]DIPYRROLO[2,1 B:3',2' D] [1,3]OXAZOCINE 5 CARBONYL)PHOSPHONIC ACID; 3 HYDROXY 4 [2,3,7 TRICHLORO 13 OXO 10 [[(TRIFLUOROMETHYL)SULFONYL]OXY] 1,13 DIHYDROBENZO[G]DIPYRROLO[2,1 B:3',2' D][1,3]OXAZOCINE 5 CARBONYL]PHENYL TRIFLUOROMETHANESULFONATE; 5 (4 CARBOXY 2 HYDROXYBENZOYL) 2,3,7 TRICHLORO 13 OXO 1,13 DIHYDROBENZO[G]DIPYRROLO[2,1 B:3',2' D] [1,3]OXAZOCINE 10 CARBOXYLIC ACID; BIM PROTEIN; CASPASE 3; CYCLIC MARINOPYRROLE DERIVATIVE; DIMETHYL 4,4' (4,4',5,5' TETRACHLORO 1' H [1,3' BIPYRROLE] 2,2' DICARBONYL)BIS(3 HYDROXYBENZOATE); MARINOPYRROLE A; METHYL 2,3,7 TRICHLORO 5 [2 HYDROXY 4 (METHOXYCARBONYL)BENZOYL] 13 OXO 1,13 DIHYDROBENZO[G]DIPYRROLO[2,1 B:3',2' D][1,3]OXAZOCINE 10 CARBOXYLATE; PROTEIN BCL XL; PROTEIN MCL 1; PYRROLE DERIVATIVE; TETRAETHYL[(4,4',5,5' TETRACHLORO 1' H [1,3' BIPYRROLE] 2,2' DICARBONYL)BIS(3 HYDROXY 4,1 PHENYLENE)]BIS(PHOSPHONATE); UNCLASSIFIED DRUG; [(4,4',5,5' TETRACHLORO 1' H [1,3' BIPYRROLE] 2,2' DICARBONYL)BIS(3 HYDROXY 4,1 PHENYLENE)]DIPHOSPHONIC ACID;

ARTICLE; CANCER CELL; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; BLOTTING, WESTERN; BREAST NEOPLASMS; CATALYSIS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INDICATORS AND REAGENTS; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; MARINE TOXINS; MEMBRANE PROTEINS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PYRROLES; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897047031     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12031335     Document Type: Article

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