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Volumn 27, Issue 2, 2014, Pages 103-111

Rediscovery of nefopam for the treatment of neuropathic pain

Author keywords

Adverse drug reactions; Molecular mechanisms of pharmacological action; Nefopam; Neuropathic pain; Nonopioid analgesics

Indexed keywords

ADRENERGIC RECEPTOR; CHLORPROMAZINE; CLONIDINE; DIPHENHYDRAMINE; DOPAMINE; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; DULOXETINE; KETAMINE; LIDOCAINE; NARCOTIC ANALGESIC AGENT; NEFOPAM; NONSTEROID ANTIINFLAMMATORY AGENT; NORADRENALIN; NORADRENALIN TRANSPORTER; ORPHENADRINE; PAROXETINE; PETHIDINE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRAMADOL; VENLAFAXINE; VOLTAGE GATED SODIUM CHANNEL;

EID: 84897045547     PISSN: 20059159     EISSN: 20930569     Source Type: Journal    
DOI: 10.3344/kjp.2014.27.2.103     Document Type: Review
Times cited : (77)

References (50)
  • 3
    • 0346102501 scopus 로고    scopus 로고
    • Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects
    • Alfonsi P, Adam F, Passard A, Guignard B, Sessler DI, Chauvin M. Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects. Anesthesiology 2004; 100: 37-43.
    • (2004) Anesthesiology , vol.100 , pp. 37-43
    • Alfonsi, P.1    Adam, F.2    Passard, A.3    Guignard, B.4    Sessler, D.I.5    Chauvin, M.6
  • 4
    • 0019222051 scopus 로고
    • Nefopam: a review of its pharmacological properties and therapeutic efficacy
    • Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs 1980; 19: 249-67.
    • (1980) Drugs , vol.19 , pp. 249-267
    • Heel, R.C.1    Brogden, R.N.2    Pakes, G.E.3    Speight, T.M.4    Avery, G.S.5
  • 6
    • 0014578272 scopus 로고
    • Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug
    • Bassett JR, Cairncross KD, Hacket NB, Story M. Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug. Br J Pharmacol 1969; 37: 69-78.
    • (1969) Br J Pharmacol , vol.37 , pp. 69-78
    • Bassett, J.R.1    Cairncross, K.D.2    Hacket, N.B.3    Story, M.4
  • 7
    • 0015335602 scopus 로고
    • Nefopam hydrochloride: a novel muscle relaxant
    • Tobin WE, Gold RH. Nefopam hydrochloride: a novel muscle relaxant. J Clin Pharmacol New Drugs 1972; 12: 230-8.
    • (1972) J Clin Pharmacol New Drugs , vol.12 , pp. 230-238
    • Tobin, W.E.1    Gold, R.H.2
  • 8
    • 0016197948 scopus 로고
    • Stereoselective demethylation of the enantiomers of nefopam, an experimental antidepressant and skeletal muscle relaxant
    • Bolt AG, Graham G, Wilson P. Stereoselective demethylation of the enantiomers of nefopam, an experimental antidepressant and skeletal muscle relaxant. Xenobiotica 1974; 4: 355-63.
    • (1974) Xenobiotica , vol.4 , pp. 355-363
    • Bolt, A.G.1    Graham, G.2    Wilson, P.3
  • 9
    • 0017043454 scopus 로고
    • Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain
    • Koe BK. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Ther 1976; 199: 649-61.
    • (1976) J Pharmacol Exp Ther , vol.199 , pp. 649-661
    • Koe, B.K.1
  • 10
    • 0015959188 scopus 로고
    • Nefopam hydrochloride for pain relief
    • Cohen A. Nefopam hydrochloride for pain relief. Curr Ther Res Clin Exp 1974; 16: 184-93.
    • (1974) Curr Ther Res Clin Exp , vol.16 , pp. 184-193
    • Cohen, A.1
  • 11
    • 0016231112 scopus 로고
    • Long-term safety of Nefopam hydrochloride (Acupan), a new analgesic formulation
    • Klotz AL. Long-term safety of Nefopam hydrochloride (Acupan), a new analgesic formulation. Curr Ther Res Clin Exp 1974; 16: 602-8.
    • (1974) Curr Ther Res Clin Exp , vol.16 , pp. 602-608
    • Klotz, A.L.1
  • 12
    • 0016255507 scopus 로고
    • A clinical evaluation of nefopam hydrochloride (Acupan): a new analgesic
    • Workmon FC, Winter L Jr. A clinical evaluation of nefopam hydrochloride (Acupan): a new analgesic. Curr Ther Res Clin Exp 1974; 16: 609-16.
    • (1974) Curr Ther Res Clin Exp , vol.16 , pp. 609-616
    • Workmon, F.C.1    Winter Jr., L.2
  • 13
    • 0016695905 scopus 로고
    • Further clinical evaluations of nefopam hydrochloride, a new analgesic
    • Kolodny AL, Winter L Jr. Further clinical evaluations of nefopam hydrochloride, a new analgesic. Curr Ther Res Clin Exp 1975; 17: 519-24.
    • (1975) Curr Ther Res Clin Exp , vol.17 , pp. 519-524
    • Kolodny, A.L.1    Winter Jr., L.2
  • 15
    • 0026213087 scopus 로고
    • Action and effectiveness of nefopam chloride in the control of postoperative shivering
    • Izzo V, Mariconti P, Tiengo M. Action and effectiveness of nefopam chloride in the control of postoperative shivering. Minerva Anestesiol 1991; 57: 760-2.
    • (1991) Minerva Anestesiol , vol.57 , pp. 760-762
    • Izzo, V.1    Mariconti, P.2    Tiengo, M.3
  • 16
    • 84875757241 scopus 로고    scopus 로고
    • Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia
    • Kim YA, Kweon TD, Kim M, Lee HI, Lee YJ, Lee KY. Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia. Korean J Anesthesiol 2013; 64: 229-33.
    • (2013) Korean J Anesthesiol , vol.64 , pp. 229-233
    • Kim, Y.A.1    Kweon, T.D.2    Kim, M.3    Lee, H.I.4    Lee, Y.J.5    Lee, K.Y.6
  • 17
    • 84868253026 scopus 로고    scopus 로고
    • Efficacy spectrum of antishivering medications: meta-analysis of randomized controlled trials
    • Park SM, Mangat HS, Berger K, Rosengart AJ. Efficacy spectrum of antishivering medications: meta-analysis of randomized controlled trials. Crit Care Med 2012; 40: 3070-82.
    • (2012) Crit Care Med , vol.40 , pp. 3070-3082
    • Park, S.M.1    Mangat, H.S.2    Berger, K.3    Rosengart, A.J.4
  • 18
    • 0034727822 scopus 로고    scopus 로고
    • Nefopam for severe hiccups
    • Bilotta F, Rosa G. Nefopam for severe hiccups. N Engl J Med 2000; 343: 1973-4.
    • (2000) N Engl J Med , vol.343 , pp. 1973-1974
    • Bilotta, F.1    Rosa, G.2
  • 19
    • 0034758821 scopus 로고    scopus 로고
    • Nefopam for refractory postoperative hiccups
    • Bilotta F, Pietropaoli P, Rosa G. Nefopam for refractory postoperative hiccups. Anesth Analg 2001; 93: 1358-60.
    • (2001) Anesth Analg , vol.93 , pp. 1358-1360
    • Bilotta, F.1    Pietropaoli, P.2    Rosa, G.3
  • 21
    • 84860647699 scopus 로고    scopus 로고
    • Tests and models of nociception and pain in rodents
    • Barrot M. Tests and models of nociception and pain in rodents. Neuroscience 2012; 211: 39-50.
    • (2012) Neuroscience , vol.211 , pp. 39-50
    • Barrot, M.1
  • 23
    • 0023223448 scopus 로고
    • The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
    • Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987; 30: 103-14.
    • (1987) Pain , vol.30 , pp. 103-114
    • Hunskaar, S.1    Hole, K.2
  • 24
    • 84873540379 scopus 로고    scopus 로고
    • Antinociceptive effect of intrathecal nefopam and interaction with morphine in formalin-induced pain of rats
    • Cho SY, Park AR, Yoon MH, Lee HG, Kim WM, Choi JI. Antinociceptive effect of intrathecal nefopam and interaction with morphine in formalin-induced pain of rats. Korean J Pain 2013; 26: 14-20.
    • (2013) Korean J Pain , vol.26 , pp. 14-20
    • Cho, S.Y.1    Park, A.R.2    Yoon, M.H.3    Lee, H.G.4    Kim, W.M.5    Choi, J.I.6
  • 25
    • 0035659279 scopus 로고    scopus 로고
    • Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat
    • Girard P, Pansart Y, Coppe MC, Gillardin JM. Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol Res 2001; 44: 541-5.
    • (2001) Pharmacol Res , vol.44 , pp. 541-545
    • Girard, P.1    Pansart, Y.2    Coppe, M.C.3    Gillardin, J.M.4
  • 26
    • 0037134286 scopus 로고    scopus 로고
    • Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat
    • Buritova J, Besson JM. Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat. Eur J Pharmacol 2002; 441: 67-74.
    • (2002) Eur J Pharmacol , vol.441 , pp. 67-74
    • Buritova, J.1    Besson, J.M.2
  • 27
    • 67849090632 scopus 로고    scopus 로고
    • Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties
    • Laboureyras E, Chateauraynaud J, Richebé P, Simonnet G. Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg 2009; 109: 623-31.
    • (2009) Anesth Analg , vol.109 , pp. 623-631
    • Laboureyras, E.1    Chateauraynaud, J.2    Richebé, P.3    Simonnet, G.4
  • 28
    • 54249115419 scopus 로고    scopus 로고
    • Nefopam for the prevention of postoperative pain: quantitative systematic review
    • Evans MS, Lysakowski C, Tramèr MR. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 2008; 101: 610-7.
    • (2008) Br J Anaesth , vol.101 , pp. 610-617
    • Evans, M.S.1    Lysakowski, C.2    Tramèr, M.R.3
  • 29
    • 0018601327 scopus 로고
    • Comparison of the analgesic dose-effect relationships of nefopam and oxycodone in postoperative pain
    • Tigerstedt I, Tammisto T, Leander P. Comparison of the analgesic dose-effect relationships of nefopam and oxycodone in postoperative pain. Acta Anaesthesiol Scand 1979; 23: 555-60.
    • (1979) Acta Anaesthesiol Scand , vol.23 , pp. 555-560
    • Tigerstedt, I.1    Tammisto, T.2    Leander, P.3
  • 32
    • 35048842029 scopus 로고    scopus 로고
    • Recent advances in the pharmacological management of pain
    • Guindon J, Walczak JS, Beaulieu P. Recent advances in the pharmacological management of pain. Drugs 2007; 67: 2121-33.
    • (2007) Drugs , vol.67 , pp. 2121-2133
    • Guindon, J.1    Walczak, J.S.2    Beaulieu, P.3
  • 33
    • 0037264650 scopus 로고    scopus 로고
    • Plasma membrane monoamine transporters: structure, regulation and function
    • Torres GE, Gainetdinov RR, Caron MG. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 2003; 4: 13-25.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 13-25
    • Torres, G.E.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 34
    • 0003032629 scopus 로고    scopus 로고
    • Antidepressants, muscle relaxants, and N-methyl-D-aspartate receptor antagonists
    • Bonica's management of pain. 3rd ed. Edited by Loeser JD, Bonica JJ. Philadelphia (PA), Lippincott Williams & Wilkins
    • Max MB, Gilron IH. Antidepressants, muscle relaxants, and N-methyl-D-aspartate receptor antagonists. In: Bonica's management of pain. 3rd ed. Edited by Loeser JD, Bonica JJ. Philadelphia (PA), Lippincott Williams & Wilkins. 2001, pp 1710-26.
    • (2001) , pp. 1710-1726
    • Max, M.B.1    Gilron, I.H.2
  • 35
    • 17044425974 scopus 로고    scopus 로고
    • Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels
    • Novelli A, Díaz-Trelles R, Groppetti A, Fernández-Sánchez MT. Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels. Amino Acids 2005; 28: 183-91.
    • (2005) Amino Acids , vol.28 , pp. 183-191
    • Novelli, A.1    Díaz-Trelles, R.2    Groppetti, A.3    Fernández-Sánchez, M.T.4
  • 36
    • 2942613207 scopus 로고    scopus 로고
    • Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents
    • Verleye M, André N, Heulard I, Gillardin JM. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res 2004; 1013: 249-55.
    • (2004) Brain Res , vol.1013 , pp. 249-255
    • Verleye, M.1    André, N.2    Heulard, I.3    Gillardin, J.M.4
  • 37
    • 0038045088 scopus 로고    scopus 로고
    • Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine
    • Biella GE, Groppetti A, Novelli A, Fernández-Sánchez MT, Manfredi B, Sotgiu ML. Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine. J Neurotrauma 2003; 20: 593-601.
    • (2003) J Neurotrauma , vol.20 , pp. 593-601
    • Biella, G.E.1    Groppetti, A.2    Novelli, A.3    Fernández-Sánchez, M.T.4    Manfredi, B.5    Sotgiu, M.L.6
  • 38
    • 34147165503 scopus 로고    scopus 로고
    • Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation
    • Novelli A, Groppetti A, Rossoni G, Manfredi B, Ferrero- Gutiérrez A, Pérez-Gómez A, et al. Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation. Amino Acids 2007; 32: 323-32.
    • (2007) Amino Acids , vol.32 , pp. 323-332
    • Novelli, A.1    Groppetti, A.2    Rossoni, G.3    Manfredi, B.4    Ferrero-Gutiérrez, A.5    Pérez-Gómez, A.6
  • 39
    • 80051536301 scopus 로고    scopus 로고
    • Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice
    • Czuczwar M, Czuczwar K, Cieszczyk J, Kis J, Saran T, Luszczki JJ, et al. Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice. Pharmacol Rep 2011; 63: 690-6.
    • (2011) Pharmacol Rep , vol.63 , pp. 690-696
    • Czuczwar, M.1    Czuczwar, K.2    Cieszczyk, J.3    Kis, J.4    Saran, T.5    Luszczki, J.J.6
  • 40
    • 33646911656 scopus 로고    scopus 로고
    • New Horizons in the development of antiepileptic drugs: innovative strategies
    • Löscher W, Schmidt D. New Horizons in the development of antiepileptic drugs: innovative strategies. Epilepsy Res 2006; 69: 183-272.
    • (2006) Epilepsy Res , vol.69 , pp. 183-272
    • Löscher, W.1    Schmidt, D.2
  • 41
    • 0024951451 scopus 로고
    • Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications
    • Hoebel BG, Hernandez L, Schwartz DH, Mark GP, Hunter GA. Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications. Ann N Y Acad Sci 1989; 575: 171-91.
    • (1989) Ann N Y Acad Sci , vol.575 , pp. 171-191
    • Hoebel, B.G.1    Hernandez, L.2    Schwartz, D.H.3    Mark, G.P.4    Hunter, G.A.5
  • 42
    • 0028183017 scopus 로고
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)
    • Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 1994; 46: 157-203.
    • (1994) Pharmacol Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3    Hartig, P.R.4    Martin, G.R.5    Mylecharane, E.J.6
  • 43
    • 37549064027 scopus 로고    scopus 로고
    • 5-HT receptor regulation of neurotransmitter release
    • Fink KB, Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev 2007; 59: 360-417.
    • (2007) Pharmacol Rev , vol.59 , pp. 360-417
    • Fink, K.B.1    Göthert, M.2
  • 44
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their function
    • Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38: 1083-152.
    • (1999) Neuropharmacology , vol.38 , pp. 1083-1152
    • Barnes, N.M.1    Sharp, T.2
  • 45
    • 70349440715 scopus 로고    scopus 로고
    • Preclinical and early clinical investigations related to monoaminergic pain modulation
    • Bannister K, Bee LA, Dickenson AH. Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics 2009; 6: 703-12.
    • (2009) Neurotherapeutics , vol.6 , pp. 703-712
    • Bannister, K.1    Bee, L.A.2    Dickenson, A.H.3
  • 46
    • 84855841418 scopus 로고    scopus 로고
    • Protein-protein interactions at the adrenergic receptors
    • Cotecchia S, Stanasila L, Diviani D. Protein-protein interactions at the adrenergic receptors. Curr Drug Targets 2012; 13: 15-27.
    • (2012) Curr Drug Targets , vol.13 , pp. 15-27
    • Cotecchia, S.1    Stanasila, L.2    Diviani, D.3
  • 47
    • 2442467014 scopus 로고    scopus 로고
    • The neurobiology of dopamine signaling
    • Girault JA, Greengard P. The neurobiology of dopamine signaling. Arch Neurol 2004; 61: 641-4.
    • (2004) Arch Neurol , vol.61 , pp. 641-644
    • Girault, J.A.1    Greengard, P.2
  • 48
    • 33644833445 scopus 로고    scopus 로고
    • The neuropathic pain scales
    • Benzon HT. The neuropathic pain scales. Reg Anesth Pain Med 2005; 30: 417-21.
    • (2005) Reg Anesth Pain Med , vol.30 , pp. 417-421
    • Benzon, H.T.1
  • 49
    • 0034053004 scopus 로고    scopus 로고
    • Nefopam enantiomers: preclinical pharmacology/ toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration
    • Mather GG, Labroo R, Le Guern ME, Lepage F, Gillardin JM, Levy RH. Nefopam enantiomers: preclinical pharmacology/ toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration. Chirality 2000; 12: 153-9.
    • (2000) Chirality , vol.12 , pp. 153-159
    • Mather, G.G.1    Labroo, R.2    Le Guern, M.E.3    Lepage, F.4    Gillardin, J.M.5    Levy, R.H.6
  • 50
    • 34548658623 scopus 로고    scopus 로고
    • French Network of Pharmacovigilance Centers. Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database
    • Durrieu G, Olivier P, Bagheri H, Montastruc JL; French Network of Pharmacovigilance Centers. Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database. Fundam Clin Pharmacol 2007; 21: 555-8.
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 555-558
    • Durrieu, G.1    Olivier, P.2    Bagheri, H.3    Montastruc, J.L.4


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