Antinociceptive effect of intrathecal nefopam and interaction with morphine in formalin-induced pain of rats

Korean Journal of Pain

Volumn 26, Issue 1, 2013, Pages 14-20

  Cho, Soo Young ^a   Park, A Reum ^a   Yoon, Myung Ha ^a   Lee, Hyung Gon ^a   Kim, Woong Mo ^a   Choi, Jeong Il ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Antinociception; Formalin; Interaction; Morphine; Nefopam

Indexed keywords

FORMALDEHYDE; MORPHINE; NEFOPAM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; EXPERIMENTAL DESIGN; ISOBOLOGRAPHIC ANALYSIS; MALE; MEDICAL PROCEDURES; NOCICEPTIVE PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN ASSESSMENT; RAT;

EID: 84873540379     PISSN: 20059159     EISSN: 20930569     Source Type: Journal    
DOI: 10.3344/kjp.2013.26.1.14     Document Type: Article

References (34)

1. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs 1980; 19: 249-67.
2. Fuller RW, Snoddy HD. Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice. Neuropharmacology 1993; 32: 995-9.
3. Piercey MF, Schroeder LA. Spinal and Supraspinal sites for morphine and nefopam analgesia in the mouse. Eur J Pharmacol 1981; 74: 135-40.
4. Evans MS, Lysakowski C, Tramèr MR. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 2008; 101: 610-7.
5. Beaver WT, Feise GA. A comparison of the analgesic effect of intramuscular nefopam and morphine in patients with postoperative pain. J Clin Pharmacol 1977; 17: 579-91.
6. McLintock TT, Kenny GN, Howie JC, McArdle CS, Lawrie S, Aitken H. Assessment of the analgesic efficacy of nefopam hydrochloride after upper abdominal surgery: a study using patient controlled analgesia. Br J Surg 1988; 75: 779-81.
7. Tramoni G, Viale JP, Cazals C, Bhageerutty K. Morphinesparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy. Eur J Anaesthesiol 2003; 20: 990-2.
8. Moffat AC, Kenny GN, Prentice JW. Postoperative nefopam and diclofenac. Evaluation of their morphine-sparing effect after upper abdominal surgery. Anaesthesia 1990; 45: 302-5.
9. Du Manoir B, Aubrun F, Langlois M, Le Guern ME, Alquier C, Chauvin M, et al. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. Br J Anaesth 2003; 91: 836-41.
10. Beloeil H, Delage N, Nègre I, Mazoit JX, Benhamou D. The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-blinded isobolographic study of their analgesic action. Anesth Analg 2004; 98: 395-400.
11. Richebé P, Picard W, Rivat C, Jelacic S, Branchard O, Leproust S, et al. Effects of nefopam on early postoperative hyperalgesia after cardiac surgery. J Cardiothorac Vasc Anesth 2012 [in press].
12. Aveline C, Gautier JF, Vautier P, Cognet F, Hetet HL, Attali JY, et al. Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam. Eur J Pain 2009; 13: 613-9.
13. Bernatzky G, Jurna I. Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats. Eur J Pharmacol 1986; 120: 75-80.
14. Fasmer OB, Berge OG, Jørgensen HA, Hole K. Antinociceptive effects of (+/-)-, (+)- and (-)-nefopam in mice. J Pharm Pharmacol 1987; 39: 508-11.
15. Millan MJ. Descending control of pain. Prog Neurobiol 2002; 66: 355-474.
16. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-6.
17. Coderre TJ, Melzack R. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 1992; 12: 3665-70.
18. Tallarida RJ. Drug synergism and dose-effect data analysis. 1st ed. New York, Chapman & Hall/CRC. 2000, pp 57-71.
19. Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg
20. Rosland JH, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J Pharm Pharmacol 1990; 42: 437-8.
21. Girard P, Pansart Y, Coppe MC, Gillardin JM. Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol Res 2001; 44: 541-5.
22. Girard P, Pansart Y, Gillardin JM. Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat. Pharmacol Biochem Behav 2004; 77: 695-703.
23. Buritova J, Besson JM. Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat. Eur J Pharmacol 2002; 441: 67-74.
24. Kapfer B, Alfonsi P, Guignard B, Sessler DI, Chauvin M. Nefopam and ketamine comparably enhance postoperative analgesia. Anesth Analg 2005; 100: 169-74.
25. Saghaei E, Moini Zanjani T, Sabetkasaei M, Naseri K. Enhancement of antinociception by co-administrations of nefopam, morphine, and nimesulide in a rat model of neuropathic pain. Korean J Pain 2012; 25: 7-15.
26. Girard P, Niedergang B, Pansart Y, Coppé MC, Verleye M. Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. Clin Exp Pharmacol Physiol 2011; 38: 170-8.
27. Girard P, Verniers D, Coppé MC, Pansart Y, Gillardin JM. Nefopam and ketoprofen synergy in rodent models of antinociception. Eur J Pharmacol 2008; 584: 263-71.
28. Delage N, Maaliki H, Beloeil H, Benhamou D, Mazoit JX. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: a study of interaction using sequential analysis and isobolographic analysis. Anesthesiology 2005; 102: 1211-6.
29. Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain 1995; 60: 91-102.
30. Rahman W, Suzuki R, Rygh LJ, Dickenson AH. Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. Neurosci Lett 2004; 361: 229-31.
31. Green GM, Scarth J, Dickenson A. An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat. Pain 2000; 89: 81-88.
32. Verleye M, Gillardin JM. Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents. Pharmacology 2009; 83: 116-21.
33. Girard P, Pansart Y, Coppé MC, Niedergang B, Gillardin JM. Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice. Pharmacology 2009; 83: 243-6.
34. Verleye M, André N, Heulard I, Gillardin JM. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res 2004; 1013: 249-55.