Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

Nature Chemical Biology

Volumn 10, Issue 4, 2014, Pages 248-250

  Xu, Yongmei ^a   Cai, Chao ^b   Chandarajoti, Kasemsiri ^a   Hsieh, Po Hung ^a   Li, Lingyun ^b   Pham, Truong Q ^a   Sparkenbaugh, Erica M ^c   Sheng, Juzheng ^d   Key, Nigel S ^c   Pawlinski, Rafal ^c   Harris, Edward N ^e   Linhardt, Robert J ^b   Liu, Jian ^a  

^a University of North Carolina   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d SHANDONG UNIVERSITY   (China)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APIXABAN; BEMIPARIN; BLOOD CLOTTING FACTOR 10A; DABIGATRAN ETEXILATE; ENOXAPARIN; FONDAPARINUX; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PROTAMINE; RIVAROXABAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BLEEDING TIME; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICOAGULANTS; ANTITHROMBINS; CARBOHYDRATE SEQUENCE; CELL ADHESION MOLECULES, NEURONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FACTOR XA; HEMORRHAGE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INDICATORS AND REAGENTS; ISOTOPE LABELING; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTAMINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFUR RADIOISOTOPES;

EID: 84897021818     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1459     Document Type: Article

References (31)

1. Kahn, S.R. et al. Chest 141 (suppl.), e195S-e226S (2012).
2. Hirsh, J., O'Donnell, M.O. & Eikelboom, J.W. Circulation 116, 552-560 (2007).
3. Arepally, G.M. & Ortel, T.L. N. Engl. J. Med. 355, 809-817 (2006).
4. Linhardt, R.J. & Liu, J. Curr. Opin. Pharmacol. 12, 217-219 (2012).
5. Melnikova, I. Nat. Rev. Drug Discov. 8, 353-354 (2009).
6. Harder, S. J. Clin. Pharmacol. 52, 964-975 (2012).
7. Weitz, J.I. & Linkins, L.A. Expert Opin. Investig. Drugs 16, 271-282 (2007).
8. Petitou, M. & van Boeckel, C.A.A. Angew. Chem. Int. Ed. 43, 3118-3133 (2004).
9. Moon, A.F. et al. Proc. Natl. Acad. Sci. USA 109, 5265-5270 (2012).
10. Chen, J., Jones, C.L. & Liu, J. Chem. Biol. 14, 986-993 (2007).
11. Zhang, Z. et al. J. Am. Chem. Soc. 130, 12998-13007 (2008).
12. Xu, Y. et al. Science 334, 498-501 (2011).
13. Zhang, Z. et al. J. Med. Chem. 51, 5498-5501 (2008).
14. Turnbull, J.E. Science 334, 462-463 (2011).
15. Liu, H., Zhang, Z. & Linhardt, R.J. Nat. Prod. Rep. 26, 313-321 (2009).
16. Sheng, J., Xu, Y., Dulaney, S.B., Huang, X. & Liu, J. J. Biol. Chem. 287, 20996-21002 (2012).
17. Pempe, E.H., Xu, Y., Gopalakrishnan, S., Liu, J. & Harris, E.H. J. Biol. Chem. 287, 20774-20783 (2012).
18. Li, L., Zhang, F., Zaia, J. & Linhardt, R.J. Anal. Chem. 84, 8822-8829 (2012).
19. Harris, E.N., Weigel, J.A. & Weigel, P.H. J. Biol. Chem. 283, 17341-17350 (2008).
20. Martinez-Gonzalez, J. & Rodriguez, C. Expert Rev. Cardiovasc. Ther. 8, 625-634 (2010).
21. Lu, G. et al. Nat. Med. 19, 446-451 (2013).
22. Bianchini, E.P., Fazavana, J., Picard, V. & Borgel, D. Blood 117, 2054-2060 (2011).
23. Atha, D.H., Lormeau, J.-C., Petitou, M., Rosenberg, R.D. & Choay, J. Biochemistry 24, 6723-6729 (1985).
24. Lee, S. et al. Nat. Biotechnol. 31, 220-226 (2013).
25. Petitou, M., Jacquinet, J.C., Choay, J., Lormeau, J.C. & Nassr, M. US Patent 4,818,816 (1989).
26. Zhang, L. et al. J. Biol. Chem. 276, 42311-42321 (2001).
27. Duncan, M.B., Chen, J., Krise, J.P. & Liu, J. Biochim. Biophys. Acta 1671, 34-43 (2004).
28. Lee, M.K. & Lander, A.D. Proc. Natl. Acad. Sci. USA 88, 2768-2772 (1991).
29. Liu, R. et al. J. Biol. Chem. 285, 34240-34249 (2010).
30. Sundaram, M. et al. Proc. Natl. Acad. Sci. USA 100, 651-656 (2003).
31. Harris, E.N., Weigel, J.A. & Weigel, P.H. J. Biol. Chem. 279, 36201-36209 (2004).