Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 14, 2012, Pages 5265-5270

  Moon, Andrea F ^a   Xu, Yongmei ^b   Woody, Susan M ^b   Krahn, Joseph M ^a   Linhardt, Robert J ^c   Liu, Jian ^b   Pedersen, Lars C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b University of North Carolina   (United States)

^c Research Rensselaer Polytechnic Institute   (United States)

Author keywords

Heparan sulfate; Oligosaccharides; Substrate specificity; Ternary complex

Indexed keywords

ADENOSINE 3',5' DIPHOSPHATE; ADENOSINE DERIVATIVE; ARGININE; CARBOHYDRATE; GLUCOSAMINE; HEPARAN SULFATE; HEPARAN SULFATE 3 O SULFOTRANSFERASE; HEPARAN SULFATE 3 O SULFOTRANSFERASE 1; HEPARAN SULFATE 3 O SULFOTRANSFERASE 3; HEPARIN; ISOENZYME; LYSINE; POLYSACCHARIDE; SULFOTRANSFERASE; THREONINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; ENZYME ENGINEERING; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANTICOAGULANTS; HEPARIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

EID: 84859467539     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117923109     Document Type: Article

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