Quantitative assessment of pancreatic fat by using unenhanced CT: Pathologic correlation and clinical implications

Radiology

Volumn 271, Issue 1, 2014, Pages 104-112

  Kim, So Yeon ^a,c   Kim, Haeryoung ^a   Cho, Jai Young ^a   Lim, Soo ^a   Cha, Kyusun ^b   Lee, Kyoung Ho ^a   Kim, Young Hoon ^a   Kim, Ji Hoon ^a   Yoon, Yoo Seok ^a   Han, Ho Seong ^a   Kang, Heung Sik ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; GLUCOSE; PANCREATIC FAT; UNCLASSIFIED DRUG; CONTRAST MEDIUM; IOHEXOL; IOPROMIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; DISEASE ASSOCIATION; DISORDERS OF CARBOHYDRATE METABOLISM; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; INTRAABDOMINAL FAT; MALE; MOLECULAR IMAGING; OUTCOME ASSESSMENT; PANCREAS RESECTION; PANCREATIC FAT FRACTION; PATIENT ASSESSMENT; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; YOUNG ADULT; ANALOGS AND DERIVATIVES; DIAGNOSTIC USE; MIDDLE AGED; PANCREATIC DISEASES; PATHOLOGY; PROCEDURES; RADIOGRAPHY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CONTRAST MEDIA; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; IOHEXOL; MALE; MIDDLE AGED; PANCREATECTOMY; PANCREATIC DISEASES; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84897016024     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.13122883     Document Type: Article

References (39)

1. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43(2 Suppl 1):S99-S112.
2. McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40(Suppl 1):S17-S29. (Pubitemid 44309539)
3. Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 2001;50(Suppl 1):S118-S121. (Pubitemid 32148232)
4. Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) 2008;16(3):522-530. (Pubitemid 351328001)
5. Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 1998;273(49):32487-32490. (Pubitemid 28557623)
6. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci U S A 1998;95(16):9558-9561. (Pubitemid 28506270)
7. Heni M, Machann J, Staiger H, et al. Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 2010;26(3):200-205.
8. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007;30(11):2916-2921. (Pubitemid 350083144)
9. Mathur A, Marine M, Lu D, et al. Nonalcoholic fatty pancreas disease. HPB (Oxford) 2007;9(4):312-318. (Pubitemid 47271323)
10. Pitt HA. Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB (Oxford) 2007;9(2):92-97. (Pubitemid 46672381)
11. Navina S, Acharya C, DeLany JP, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med 2011;3(107):ra110.
12. Lee JS, Kim SH, Jun DW, et al. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol 2009;15(15):1869-1875.
13. Raeder H, Haldorsen IS, Ersland L, et al. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes 2007;56(2):444-449.
14. Schwenzer NF, Machann J, Martirosian P, et al. Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest Radiol 2008;43(5):330-337. (Pubitemid 351572210)
15. Lingvay I, Esser V, Legendre JL, et al. Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab 2009;94(10):4070-4076.
16. Hu HH, Kim HW, Nayak KS, Goran MI. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 2010;18(4):841-847.
17. Hoff FL, Gabriel H, Hammond NA, Gore RM. Pancreas: normal anatomy and examination techniques. In: Gore RM, Levine MS, eds. Textbook of gastrointestinal radiology. Philadelphia, Pa: Saunders, 2008;1839-1853.
18. Ricci C, Longo R, Gioulis E, et al. Noninvasive in vivo quantitative assessment of fat content in human liver. J Hepatol 1997;27(1):108-113. (Pubitemid 27357063)
19. Zinreich SJ, Kennedy DW, Malat J, et al. Fungal sinusitis: diagnosis with CT and MR imaging. Radiology 1988;169(2):439-444.
20. Ly JN, Miller FH. MR imaging of the pancreas: a practical approach. Radiol Clin North Am 2002;40(6):1289-1306. (Pubitemid 35404055)
21. Siegelman ES, Rosen MA. Imaging of hepatic steatosis. Semin Liver Dis 2001;21(1):71-80. (Pubitemid 32240487)
22. Park SH, Kim PN, Kim KW, et al. Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment. Radiology 2006;239(1):105-112.
23. Kodama Y, Ng CS, Wu TT, et al. Comparison of CT methods for determining the fat content of the liver. AJR Am J Roentgenol 2007;188(5):1307-1312. (Pubitemid 46668513)
24. Saisho Y, Butler AE, Meier JJ, et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 2007;20(8):933-942. (Pubitemid 350074312)
25. Gilbeau JP, Poncelet V, Libon E, Derue G, Heller FR. The density, contour, and thickness of the pancreas in diabetics: CT findings in 57 patients. AJR Am J Roentgenol 1992;159(3):527-531.
26. Wagenknecht LE, Langefeld CD, Scherzinger AL, et al. Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 2003;52(10):2490-2496. (Pubitemid 37210536)
27. Utzschneider KM, Carr DB, Hull RL, et al. Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 2004;53(11):2867-2872. (Pubitemid 39425912)
28. Baumgartner RN, Heymsfield SB, Roche AF, Bernardino M. Abdominal composition quantified by computed tomography. Am J Clin Nutr 1988;48(4):936-945.
29. Yoshizumi T, Nakamura T, Yamane M, et al. Abdominal fat: standardized technique for measurement at CT. Radiology 1999;211(1):283-286. (Pubitemid 29161765)
30. Roldan-Valadez E, Favila R, Martínez-López M, Uribe M, Ríos C, Méndez-Sánchez N. In vivo 3T spectroscopic quantification of liver fat content in nonalcoholic fatty liver disease: Correlation with biochemical method and morphometry. J Hepatol 2010;53(4):732-737.
31. d'Assignies G, Ruel M, Khiat A, et al. Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods. Eur Radiol 2009;19(8):2033-2040.
32. World Health Organization. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia: Report of a WHO/IDF Consultation. Geneva, Switzerland: World Health Organization, 2006.
33. Limanond P, Raman SS, Lassman C, et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 2004;230(1):276-280. (Pubitemid 37549813)
34. Tiikkainen M, Bergholm R, Vehkavaara S, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 2003;52(3):701-707. (Pubitemid 36323577)
35. Guiu B, Petit JM, Loffroy R, et al. Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy. Radiology 2009;250(1):95-102.
36. Thomas EL, Hamilton G, Patel N, et al. Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 2005;54(1):122-127. (Pubitemid 40007230)
37. van Werven JR, Marsman HA, Nederveen AJ, et al. Assessment of hepatic steatosis in patients undergoing liver resection: comparison of US, CT, T1-weighted dual-echo MR imaging, and point-resolved 1H MR spectroscopy. Radiology 2010;256(1):159-168.
38. Kim HJ, Byun JH, Park SH, et al. Focal fatty replacement of the pancreas: usefulness of chemical shift MRI. AJR Am J Roentgenol 2007;188(2):429-432. (Pubitemid 46167745)
39. Matsumoto S, Mori H, Miyake H, et al. Uneven fatty replacement of the pancreas: evaluation with CT. Radiology 1995;194(2):453-458.