Effect of treadmill exercise timing on repair of full-thickness defects of articular cartilage by bone-derived mesenchymal stem cells: An experimental investigation in rats

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Song, Jin Qi ^a   Dong, Fu ^b   Li, Xue ^a   Xu, Chang Peng ^a   Cui, Zhuang ^a   Jiang, Nan ^a   Jia, Jun Jie ^a   Yu, Bin ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Department of Orthopaedics Beihai People's Hospital of Guangxi Province   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE REMODELING; CHONDROPATHY; CONTROLLED STUDY; EXERCISE INTENSITY; FEMUR CONDYLE; FULL THICKNESS CARTILAGE DEFECT; HISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PATELLA; PROTEIN EXPRESSION; RAT; SITTING; TREADMILL EXERCISE; TREATMENT DURATION; TREATMENT RESPONSE;

AGGRECANS; ANALYSIS OF VARIANCE; ANIMALS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DNA PRIMERS; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STROMAL CELLS; PHYSICAL CONDITIONING, ANIMAL; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; WOUND HEALING;

EID: 84897015093     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090858     Document Type: Article

References (49)

1. Simon TM, Jackson DW (2006) Articular cartilage: injury pathways and treatment options. Sports Med Arthrosc 14(3): 146-154.
2. Widuchowski W, Lukasik P, Kwiatkowski G, Faltus R, Szyluk K, et al. (2008) Isolated full thickness chondral injuries. Prevalance and outcome of treatment. A retrospective study of 5233 knee arthroscopies. Acta Chir Orthop Traumatol Cech 75(5): 382-386.
3. Hurtig MB, Fretz PB, Doige CE, Schnurr DL (1988) Effects of lesion size and location on equine articular cartilage repair. Can J Vet Res 52(1): 137-146.
4. Kincaid SA, Van Sickle DC (1982) Effects of exercise on the histochemical changes of articular chondrocytes in adult dogs. Am J Vet Res 43(7): 1218-1226.
5. Zhuo Q, Yang W, Chen J, Wang Y (2012) Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol 8(12): 729-737.
6. Vanwanseele B, Lucchinetti E, Stussi E (2002) The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions. Osteoarthritis Cartilage 10(5): 408-419. (Pubitemid 34662376)
7. Troyer H (1975) The effect of short-term immobilization on the rabbit knee joint cartilage. A histochemical study. Clin Orthop Relat Res 107): 249-257.
8. Videman T, Eronen I, Candolin T (1981) [3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits. Biochem J 200(2): 435-440. (Pubitemid 12218267)
9. Haapala J, Arokoski J, Pirttimaki J, Lyyra T, Jurvelin J, et al. (2000) Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization. Int J Sports Med 21(1): 76-81. (Pubitemid 30066090)
10. O'Driscoll SW, Keeley FW, Salter RB (1988) Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year. J Bone Joint Surg Am 70(4): 595-606.
11. Moran ME, Kim HK, Salter RB (1992) Biological resurfacing of full-thickness defects in patellar articular cartilage of the rabbit. Investigation of autogenous periosteal grafts subjected to continuous passive motion. J Bone Joint Surg Br 74(5): 659-667.
12. Palmoski MJ, Colyer RA, Brandt KD (1980) Joint motion in the absence of normal loading does not maintain normal articular cartilage. Arthritis Rheum 23(3): 325-334. (Pubitemid 10134342)
13. Galois L, Etienne S, Grossin L, Watrin-Pinzano A, Cournil-Henrionnet C, et al. (2004) Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study. Osteoarthritis Cartilage 12(10): 779-786. (Pubitemid 39272840)
14. Ni GX, Zhan LQ, Gao MQ, Lei L, Zhou YZ, et al. (2011) Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Res Ther 13(6): R192.
15. Kiviranta I, Tammi M, Jurvelin J, Saamanen AM, Helminen HJ (1988) Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs. J Orthop Res 6(2): 188-195.
16. Fransen M, McConnell S, Bell M (2003) Exercise for osteoarthritis of the hip or knee. Cochrane Database Syst Rev 3): D4286.
17. Ni GX, Lei L, Zhou YZ (2012) Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage. Arthritis Res Ther 14(6): R256.
18. Williams JM, Brandt KD (1984) Exercise increases osteophyte formation and diminishes fibrillation following chemically induced articular cartilage injury. J Anat 139 (Pt 4)(599-611.
19. Videman T (1982) The effect of running on the osteoarthritic joint: an experimental matched-pair study with rabbits. Rheumatol Rehabil 21(1): 1-8.
20. Carver SE, Heath CA (1999) Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng 62(2): 166-174. (Pubitemid 29001901)
21. O'Conor CJ, Case N, Guilak F (2013) Mechanical regulation of chondrogenesis. Stem Cell Res Ther 4(4): 61.
22. van Weeren PR, Firth EC, Brommer H, Hyttinen MM, Helminen AE, et al. (2008) Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse. Equine Vet J 40(2): 128-135. (Pubitemid 351717160)
23. Kim W, Kawcak CE, McIlwraith CW, Firth EC, McArdle BH, et al. (2009) Influence of early conditioning exercise on the development of gross cartilage defects and swelling behavior of cartilage extracellular matrix in the equine midcarpal joint. Am J Vet Res 70(5): 589-598.
24. Moffat PA, Firth EC, Rogers CW, Smith RK, Barneveld A, et al. (2008) The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses. Equine Vet J 40(2): 136-140. (Pubitemid 351717161)
25. Nugent GE, Law AW, Wong EG, Temple MM, Bae WC, et al. (2004) Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle. Osteoarthritis Cartilage 12(10): 826-833. (Pubitemid 39272846)
26. French DA, Barber SM, Leach DH, Doige CE (1989) The effect of exercise on the healing of articular cartilage defects in the equine carpus. Vet Surg 18(4): 312-321.
27. Espanha MM, Lammi PE, Hyttinen MM, Lammi MJ, Helminen HJ (2001) Extracellular matrix composition of full-thickness defect repair tissue is little influenced by exercise in rat articular cartilage. Connect Tissue Res 42(2): 97-109. (Pubitemid 33040397)
28. Kim W, Kawcak CE, McIlwraith CW, Firth EC, Broom ND (2012) Histologic and histomorphometric evaluation of midcarpal joint defects in Thoroughbreds raised with and without early conditioning exercise. Am J Vet Res 73(4): 498-507.
29. Haller JM, Potter MQ, Kubiak EN (2013) Weight bearing after a periarticular fracture: what is the evidence? Orthop Clin North Am 44(4): 509-519.
30. Mankin HJ (1974) The reaction of articular cartilage to injury and osteoarthritis (first of two parts). N Engl J Med 291(24): 1285-1292.
31. Reinold MM, Wilk KE, Macrina LC, Dugas JR, Cain EL (2006) Current concepts in the rehabilitation following articular cartilage repair procedures in the knee. J Orthop Sports Phys Ther 36(10): 774-794. (Pubitemid 44563797)
32. Todhunter RJ, Minor RR, Wootton JA, Krook L, Burton-Wurster N, et al. (1993) Effects of exercise and polysulfated glycosaminoglycan on repair of articular cartilage defects in the equine carpus. J Orthop Res 11(6): 782-795. (Pubitemid 24040159)
33. Lammi PE, Lammi MJ, Tammi RH, Helminen HJ, Espanha MM (2001) Strong hyaluronan expression in the full-thickness rat articular cartilage repair tissue. Histochem Cell Biol 115(4): 301-308. (Pubitemid 32323886)
34. Chang NJ, Lin CC, Li CF, Wang DA, Issariyaku N, et al. (2012) The combined effects of continuous passive motion treatment and acellular PLGA implants on osteochondral regeneration in the rabbit. Biomaterials 33(11): 3153-3163.
35. Elsaid KA, Zhang L, Waller K, Tofte J, Teeple E, et al. (2012) The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection. Osteoarthritis Cartilage 20(8): 940-948.
36. Lee YJ, Park JA, Yang SH, Kim KY, Kim BK, et al. (2011) Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system. Rheumatol Int 31(12): 1571-1576.
37. LaForgia J, Withers RT, Gore CJ (2006) Effects of exercise intensity and duration on the excess post-exercise oxygen consumption. J Sports Sci 24(12): 1247-1264. (Pubitemid 44762626)
38. Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi CV (1979) Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol 47(6): 1278-1283. (Pubitemid 10168974)
39. Huang AH, Farrell MJ, Kim M, Mauck RL (2010) Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cellladen hydrogel. Eur Cell Mater 19(72-85.
40. Pajerowski JD, Dahl KN, Zhong FL, Sammak PJ, Discher DE (2007) Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A 104(40): 15619-15624. (Pubitemid 350035348)
41. Albro MB, Chahine NO, Li R, Yeager K, Hung CT, et al. (2008) Dynamic loading of deformable porous media can induce active solute transport. J Biomech 41(15): 3152-3157.
42. Chahine NO, Albro MB, Lima EG, Wei VI, Dubois CR, et al. (2009) Effect of dynamic loading on the transport of solutes into agarose hydrogels. Biophys J 97(4): 968-975.
43. Dudek BC, Adams N, Boice R, Abbott ME (1983) Genetic influences on digging behaviors in mice (Mus musculus) in laboratory and seminatural settings. J Comp Psychol 97(3): 249-259.
44. Kreder HJ, Moran M, Keeley FW, Salter RB (1994) Biologic resurfacing of a major joint defect with cryopreserved allogeneic periosteum under the influence of continuous passive motion in a rabbit model. Clin Orthop Relat Res 300): 288-296.
45. Roos EM, Dahlberg L (2005) Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 52(11): 3507-3514. (Pubitemid 41612217)
46. Soder S, Aigner T (2011) [Osteoarthritis. Etiology, typing, staging and histological grading]. Pathologe 32(3): 183-192.
47. Dausse Y, Grossin L, Miralles G, Pelletier S, Mainard D, et al. (2003) Cartilage repair using new polysaccharidic biomaterials: macroscopic, histological and biochemical approaches in a rat model of cartilage defect. Osteoarthritis Cartilage 11(1): 16-28. (Pubitemid 36157569)
48. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6): 1101-1108. (Pubitemid 351818697)
49. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4): 402-408. (Pubitemid 34164012)