Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats

Arthritis Research and Therapy

Volumn 13, Issue 6, 2011, Pages

  Ni, Guo Xin ^a   Zhan, Li Qiong ^b   Gao, Mei Qin ^b   Lei, Lei ^b   Zhou, Yue Zhu ^b   Pan, Yan Xia ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cartilage; Inhibitor; Mmp 3; Osteoarthritis; Running exercise

Indexed keywords

COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN; MESSENGER RNA; STROMELYSIN; STROMELYSIN INHIBITOR; ENZYME INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CATABOLISM; CHONDROPROTECTION; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE INTENSITY; FEMUR CONDYLE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KNEE; LOW DRUG DOSE; MALE; NONHUMAN; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITTING; TREADMILL EXERCISE; TREATMENT DURATION; ANIMAL; ARTICULAR CARTILAGE; DOSE RESPONSE; DRUG EFFECT; EXERCISE TEST; GENE EXPRESSION REGULATION; GENETICS; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM; RANDOMIZATION; RUNNING; TIME; WISTAR RAT;

ANIMALS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXERCISE TEST; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRA-ARTICULAR; MALE; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE INHIBITORS; RANDOM ALLOCATION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RUNNING; TIME FACTORS;

EID: 82055171886     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3521     Document Type: Article

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