Effect of dynamic loading on the transport of solutes into agarose hydrogels

Biophysical Journal

Volumn 97, Issue 4, 2009, Pages 968-975

  Chahine, Nadeen O ^a   Albro, Michael B ^b   Lima, Eric G ^b   Wei, Victoria I ^b   Dubois, Christopher R ^b   Hung, Clark T ^b   Ateshian, Gerard A ^b  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE; DEXTRAN; GROWTH FACTOR; PHOSPHATE BUFFERED SALINE;

ARTICLE; BIOMECHANICS; COMPRESSIVE STRENGTH; CONTROLLED STUDY; DIFFUSION; HYDROGEL; MOLECULAR WEIGHT; NUTRIENT DYNAMICS; NUTRIENT LOADING; SOLUTE; STEADY STATE; SWELLING; TISSUE ENGINEERING; TISSUE GROWTH;

EID: 69449100455     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.05.047     Document Type: Article

References (24)

1. McKibbin, B., and A. Maroudas. 1974. Nutrition and metabolism. In Adult Articular Cartilage. M. Freeman, editor. Grune & Stratton, New York.
2. Torzilli, P. A., J. M. Arduino, J. D. Gregory, and M. Bansal. 1997. Effect of proteoglycan removal on solute mobility in articular cartilage. J. Biomech. 30:895-902.
3. Quinn, T. M., V. Morel, and J. J. Meister. 2001. Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. J. Biomech. 34:1463-1469.
4. Quinn, T. M., C. Studer, A. J. Grodzinsky, and J. J. Meister. 2002. Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants. J. Biochem. Biophys. Methods. 52:83-95.
5. O'Hara, B. P., J. P. Urban, and A. Maroudas. 1990. Influence of cyclic loading on the nutrition of articular cartilage. Ann. Rheum. Dis. 49:536-539.
6. Urban, J. P., S. Holm, A. Maroudas, and A. Nachemson. 1982. Nutrition of the intervertebral disc: effect of fluid flow on solute transport. Clin. Orthop. Relat. Res. 170:296-302.
7. Bonassar, L. J., A. J. Grodzinsky, E. H. Frank, S. G.Davila,N. R.Bhaktav, et al. 2001. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J. Orthop. Res. 19:11-17.
8. Mauck, R. L., S. L. Seyhan, G. A. Ateshian, and C. T. Hung. 2002. Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels. Ann. Biomed. Eng. 30:1046-1056.
9. Mauck, R. L., M. A. Soltz, C. C. Wang, D. D. Wong, P. H. Chao, et al. 2000. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J. Biomech. Eng. 122:252-260.
10. Mauck, R. L., C. C. Wang, E. S. Oswald, G. A. Ateshian, and C. T. Hung. 2003. The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthritis Cartilage. 11:879-890.
11. Leddy, H. A., H. A. Awad, and F. Guilak. 2004. Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. J. Biomed. Mater. Res. B Appl. Biomater. 70:397-406.
12. Leddy, H. A., and F. Guilak. 2003. Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann. Biomed. Eng. 31:753-760.
13. White, J. A., and W. M. Deen. 2002. Agarose-dextran gels as synthetic analogs of glomerular basement membrane: water permeability. Biophys. J. 82:2081-2089.
14. Maroudas, A. 1970. Distribution and diffusion of solutes in articular cartilage. Biophys. J. 10:365-379.
15. Kosto, K. B., and W. M. Deen. 2005. Hindered convection of macromolecules in hydrogels. Biophys. J. 88:277-286.
16. Deen, W. M. 1987. Hindered transport of large molecules in liquid-filled pores. Am. Inst. Chem. Eng. J. 33:1409-1425.
17. Roger, P., C. Mattisson, A. Axelsson, and G. Zacchi. 2000. Use of holographic laser interferometry to study the diffusion of polymers in gels. Biotechnol. Bioeng. 69:654-663.
18. Pluen, A., P. A. Netti, R. K. Jain, and D. A. Berk. 1999. Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys. J. 77:542-552. (Pubitemid 29305250)
19. Aymard, P., D. R. Martin, K. Plucknett, T. J. Foster, A. H. Clark, et al. 2001. Influence of thermal history on the structural and mechanical properties of agarose gels. Biopolymers. 59:131-144. (Pubitemid 32694751)
20. Evans, R. C., and T. M. Quinn. 2006. Solute convection in dynamically compressed cartilage. J. Biomech. 39:1048-1055.
21. Mauck, R. L., C. T. Hung, and G. A. Ateshian. 2003. Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering. J. Biomech. Eng. 125:602-614.
22. Albro, M. A., N. O. Chahine, R. Li, K. Yeager, C. T. Hung, et al. 2008. Dynamic loading of deformable porous media can induce active solute transport. J. Biomech. 41:3152-3157.
23. Mauck, R. L., S. B. Nicoll, S. L. Seyhan, G. A. Ateshian, and C. T. Hung. 2003. Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. Tissue Eng. 9:597-611.
24. Mauck, R. L., C. C.-B. Wang, Q. Cheng, N. Gabriel, E. S. Oswald, et al. 2003. Optimization of parameter for articular cartilage tissue engineering with deformational loading. In Transactions of the Orthopedic Research Society. New Orleans, LA. Paper# 0353.