Relationship status update for PTP1B and LepR: It's complicated

Molecular Metabolism

Volumn 3, Issue 3, 2014, Pages 217-218

  Fischer, Katrin ^a   Müller, Timo D ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; LEPTIN; PROTEIN TYROSINE PHOSPHATASE 1B;

BODY WEIGHT; ENERGY METABOLISM; ENZYME INHIBITION; ENZYME REGULATION; GENE DELETION; GLUCOSE METABOLISM; HYPOTHALAMUS; NONHUMAN; NOTE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 84896998031     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.01.015     Document Type: Note

References (10)

1. Myers M.G., Cowley M.A., Münzberg H. Mechanisms of leptin action and leptin resistance. Annual Review of Physiology 2008, 70:537-556.
2. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy AL., et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
3. Delibegovic M., Bence K.K., Mody N., Hong E.G., Ko H.J., Kim J.K., et al. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Molecular and Cellular Biology 2007, 27:7727-7734.
4. Agouni A., Mody N., Owen C., Czopek A., Zimmer D., Bentires-Alj M., et al. Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. Biochemical Journal 2011, 438:369-378.
5. Owen C., Czopek A., Agouni A., Grant L., Judson R., Lees E.K., et al. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One 2012, 7:e32700.
6. Bence K.K., Delibegovic M., Xue B., Gorgun C.Z., Hotamisligil G.S., Neel B.G., et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine 2010, 12:917-924.
7. Tsou R.C., Zimmer D.J., De Jonghe B.C., Bence K.K. Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology 2012, 153:4227-4237.
8. De Jonghe B.C., Hayes M.R., Banno R., Skibicka K.P., Zimmer D.J., Bowen K.A., et al. Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American Journal of Physiology: Endocrinology and Metabolism 2011, 300:e1002-1011.
9. De Jonghe B.C., Hayes M.R., Zimmer D.J., Kanoski S.E., Grill H.J., Bence K.K. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American Journal of Physiology: Endocrinology and Metabolism 2012, 303:e644-651.
10. Tsou R.C., Rak K.S., Zimmer D.J., Bence K.K. Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor. Molecular Metabolism 2014, 3(3):301-312.