Bodily self and immune self: Is there a link?

Frontiers in Human Neuroscience

Volumn 8, Issue MAR, 2014, Pages

  Costantini, Marcello ^a,b  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Bodily self consciousness; Immune system; Immunity; Multisensory integration; Sense of ownership

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6;

ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEPTH PERCEPTION; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL PARAMETERS; INFLAMMATION; INNATE IMMUNITY; MEMORY CELL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROLOGIC EXAMINATION; POSTNATAL DEVELOPMENT; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PUBLICATION; RUBBER HAND ILLUSION; SELF CONCEPT; SENSORIMOTOR INTEGRATION; SPATIAL MEMORY;

EID: 84896970927     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2014.00138     Document Type: Article

References (38)

1. Arzy, S., Thut, G., Mohr, C., Michel, C. M., and Blanke, O. (2006). Neural basis of embodiment: distinct contributions of temporoparietal junction and extrastriate body area. J. Neurosci. 26, 8074-8081. doi: 10.10.1523/JNEUROSCI.0745-06.2006
2. Aspell, J. E., Lenggenhager, B., and Blanke, O. (2009). Keeping in touch with one's self: multisensory mechanisms of self-consciousness. PLoS ONE 4:e6488. doi: 10.10.1371/journal.pone.0006488
3. Barnsley, N., Mcauley, J. H., Mohan, R., Dey, A., Thomas, P., and Moseley, G. L. (2011). The rubber hand illusion increases histamine reactivity in the real arm. Curr. Biol. 21, R945-R946. doi: 10.10.1016/j.cub.2011.10.039
4. Blanke, O. (2012). Multisensory brain mechanisms of bodily self-consciousness. Nat. Rev. Neurosci. 13, 556-571. doi: 10.10.1038/nrn3292nrn3292
5. Blanke, O., and Metzinger, T. (2009). Full-body illusions and minimal phenomenal selfhood. Trends Cogn. Sci. 13, 7-13. doi: 10.10.1016/j.tics.2008.10.003 S1364-6613(08)00250-7
6. Boulanger, L. M. (2009). Immune proteins in brain development and synaptic plasticity. Neuron 64, 93-109. doi: 10.10.1016/j.neuron.2009.09.001 Boulanger, L. M., and Shatz, C. J. (2004). Immune signalling in neural development, synaptic plasticity and disease. Nat. Rev. Neurosci. 5, 521-531. doi:10.1038/nrn1428
7. Chandrasekaran, C., Trubanova, A., Stillittano, S., Caplier, A., and Ghazanfar, A. A. (2009). The natural statistics of audiovisual speech. PLoS Comput. Biol. 5:e1000436. doi: 10.10.1371/journal.pcbi.1000436
8. Damasio, A. (2003). Mental self: the person within. Nature 423:227. doi: 10.10.1038/423227a
9. David, N., Fiori, F., and Aglioti, S. M. (2013). Susceptibility to the rubber hand illusion does not tell the whole body-awareness story. Cogn. Affect. Behav. Neurosci. doi: 10.10.3758/s13415-013-0190-6. [Epub ahead of print].
10. Ehrsson, H. H. (2012). The Concept of Body Ownership and its Relation to Multisensory Integration. Cambridge, MA: MIT Press.
11. Ferri, F., Frassinetti, F., Ardizzi, M., Costantini, M., and Gallese, V. (2012). A sensorimotor network for the bodily self. J. Cogn. Neurosci. 24, 1584-1595. doi: 10.10.1162/jocn_a_00230
12. Ferri, F., Frassinetti, F., Costantini, M., and Gallese, V. (2011). Motor simulation and the bodily self. PLoS ONE 6:e17927. doi: 10.10.1371/journal.pone.0017927
13. Gallagher, S. (2005). How the Body Shapes the Mind. Oxford: Oxford University Press. doi: 10.10.1093/ 0199271941.001.0001
14. Haans, A., Kaiser, F. G., Bouwhuis, D. G., and Ijsselsteijn, W. A. (2012). Individual differences in the rubber-hand illusion: predicting self-reports of people's personal experiences. Acta Psychol. (Amst). 141, 169-177. doi: 10.10.1016/j.actpsy.2012. 07.016
15. Haggard, P., Taylor-Clarke, M., and Kennett, S. (2003). Tactile perception, cortical representation and the bodily self. Curr. Biol. 13, R170-R173. doi:10.1016/ S0960-9822(03)00115-5
16. Hein, A. M., Stasko, M. R., Matousek, S. B., Scott- Mckean, J. J., Maier, S. F., Olschowka, J. A., et al. (2010). Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav. Immun. 24, 243-253. doi: 10.10.1016/j.bbi.2009.10.002
17. Houghton, A. N. (1994). Cancer antigens: immune recognition of self and altered self. J. Exp. Med. 180, 1-4. doi: 10.10.1084/jem.180.1.1
18. Ionta, S., Gassert, R., and Blanke, O. (2011a). Multisensory and sensorimotor foundation of bodily self-consciousness - an interdisciplinary approach. Front. Psychol. 2:383. doi: 10.10.3389/fpsyg.2011. 00383
19. Ionta, S., Heydrich, L., Lenggenhager, B., Mouthon, M., Fornari, E., Chapuis, D., et al. (2011b). Multisensory mechanisms in temporo-parietal cortex support self-location and first-person perspective. Neuron 70, 363-374. doi: 10.10.1016/j. neuron.2011.03.009
20. Ionta, S., Martuzzi, R., Salomon, R., and Blanke, O. (2014). The Brain Network reflecting Bodily Self-consciousness: a functional connectivity study. Soc. Cogn. Affect. Neurosci. doi: 10.10.1093/scan/nst185. [Epub ahead of print].
21. Lee, R. H., Mills, E. A., Schwartz, N., Bell, M. R., Deeg, K. E., Ruthazer, E. S., et al. (2010). Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system. Neural Dev. 5:2. doi:10.1186/1749-8104-5-2
22. Legrand, D. (2006). The bodily self: The sensori- motor roots of pre-reflective self-consciousness. Phenomenol. Cogn. Sci. 5, 89-118. doi: 10.10.1007/ s11097-005-9015-6
23. Li, A. J., Katafuchi, T., Oda, S., Hori, T., and Oomura, Y. (1997). Interleukin-6 inhibits long-term poten-tiation in rat hippocampus slices. Brain Res. 748, 30-38. doi: 10.10.1016/S0006-8993(96)01283-8
24. Limanowski, J., and Blankenburg, F. (2013). Minimal self-models and the free energy principle. Front. Hum. Neurosci. 7:547. doi: 10.10.3389/fnhum.2013. 00547
25. Matzinger, P. (2002). The danger model: a renewed sense of self. Science 296, 301-305. doi: 10.10.1126/science.1071059
26. Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., and O'banion, M. K. (2009). Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory. Neuroscience 164, 1484-1495. doi: 10.10.1016/j.neuroscience.2009.08.073
27. Nossal, G. J. (2001). A purgative mastery. Nature 412, 685-686. doi: 10.10.1038/35089152
28. Oitzl, M., Van Oers, H., Schobitz, B., and De Kloet, E. R. (1993). Interleukin-1β, but not interleukin-6, impairs spatial navigation learning. Brain Res. 613, 160-163. doi: 10.10.1016/0006-8993(93) 90468-3
29. Pacherie, E. (2008). The phenomenology of action: a conceptual framework. Cognition 107, 179-217. doi: 10.10.1016/j.cognition.2007.09.003
30. Pradeu, T., Jaeger, S., and Vivier, E. (2013). The speed of change: towards a discontinuity theory of immunity? Nat. Rev. Immunol. 13, 764-769. doi:10.1038/nri3521
31. Schneider, H., Pitossi, F., Balschun, D., Wagner, A., Del Rey, A., and Besedovsky, H. O. (1998). A neuromodulatory role of interleukin-1β in the hippocampus. Proc. Natl. Acad. Sci. U.S.A. 95, 7778-7783. doi: 10.10.1073/pnas.95.13.7778
32. Stein, B. E., Labos, E., and Kruger, L. (1973). Sequence of changes in properties of neurons of superior colliculus of the kitten during maturation. J. Neurophysiol. 36, 667-679.
33. Tsakiris, M., Tajadura-Jiménez, A., and Costantini, M. (2011). Just a heartbeat away from one's body: interoceptive sensitivity predicts malleability of body-representations. Proc. R. Soc. B Biol. Sci. 278, 2470-2476. doi: 10.10.1098/rspb.2010.2547
34. Wallace, M. T., Perrault, T. J. Jr., Hairston, W. D., and Stein, B. E. (2004). Visual experience is necessary for the development of multisensory integration. J. Neurosci. 24, 9580-9584. doi: 10.10.1523/ JNEUROSCI.2535-04.2004
35. Wallace, M. T., and Stein, B. E. (1997). Development of multisensory neurons and multisensory integration in cat superior colliculus. J. Neurosci. 17, 2429-2444.
36. Wallace, M. T., and Stein, B. E. (2001). Sensory and multisensory responses in the newborn monkey superior colliculus. J. Neurosci. 21, 8886-8894.
37. Wallace, M. T., and Stein, B. E. (2007). Early experience determines how the senses will interact. J. Neurophysiol. 97, 921-926. doi: 10.10.1152/jn. 00497.2006
38. Yirmiya, R., and Goshen, I. (2011). Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav. Immun. 25, 181-213. doi: 10.10.1016/j.bbi.2010.10.015