Rapid conversion of Pseudomonas aeruginosa to a spherical cell morphotype facilitates tolerance to carbapenems and penicillins but increases susceptibility to antimicrobial peptides

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 4, 2014, Pages 1956-1962

  Monahan, Leigh G ^a   Turnbull, Lynne ^a   Osvath, Sarah R ^a   Birch, Debra ^b   Charles, Ian G ^a   Whitchurch, Cynthia B ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; MEROPENEM; PENICILLIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIAL OUTER MEMBRANE; BACTERIAL STRAIN; BACTERIUM TRANSFORMATION; MORPHOTYPE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SPHERICAL CELL;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CARBAPENEMS; DRUG RESISTANCE, BACTERIAL; PENICILLINS; PSEUDOMONAS AERUGINOSA;

EID: 84896943492     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01901-13     Document Type: Article

References (33)

1. Poole K. 2011. Pseudomonas aeruginosa: resistance to the max. Front. Microbiol. 2:65. http://dx.doi.org/10.3389/fmicb.2011.00065.
2. Hamad B. 2010. The antibiotics market. Nat. Rev. Drug Discov. 9:675- 676. http://dx.doi.org/10.1038/nrd3267.
3. Kong KF, Schneper L, Mathee K. 2009. Beta-lactam antibiotics: from antibiosis to resistance and bacteriology. APMIS 118:1-36. http://dx.doi.org/10. 1111/j.1600-0463.2009.02563.x.
4. Bush K. 2012. Antimicrobial agents targeting bacterial cell walls and cell membranes. Rev. Sci. Tech. 31:43-56.
5. Spratt BG, Cromie KD. 1988. Penicillin-binding proteins of Gramnegative bacteria. Rev. Infect. Dis. 10:699-711.
6. Tomasz A. 1986. Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics. Rev. Infect. Dis. 8(Suppl 3):S260-S278.
7. Trautmann M, Heinemann M, Zick R, Moricke A, Seidelmann M, Berger D. 1998. Antibacterial activity of meropenem against Pseudomonas aeruginosa, including antibiotic-induced morphological changes and en-dotoxin- liberating effects. Eur. J. Clin. Microbiol. Infect. Dis. 17:754-760. (Pubitemid 29219126)
8. Horii T, Kobayashi M, Sato K, Ichiyama S, Ohta M. 1998. An in-vitro study of carbapenem-induced morphological changes and endotoxin release in clinical isolates of Gram-negative bacilli. J. Antimicrob. Chemother. 41:435-442. (Pubitemid 28167502)
9. Nishino T, Nakazawa S. 1976. Bacteriological study on effects of betalactam group antibiotics in high concentrations. Antimicrob. Agents Chemother. 9:1033-1042.
10. Chadwick P. 1969. Effect of carbenicillin on Pseudomonas aeruginosa. Can. Med. Assoc. J. 101:74-80.
11. Zar FA, Kany RJ, Jr. 1985. In vitro studies of investigational beta-lactams as possible therapy for Pseudomonas aeruginosa endocarditis. Antimicrobial. Agents Chemother. 27:1-3. (Pubitemid 15198144)
12. Tam VH, Schilling AN, Melnick DA, Coyle EA. 2005. Comparison of beta-lactams in counter-selecting resistance of Pseudomonas aeruginosa. Diagn. Microbiol. Infect. Dis. 52:145-151. http://dx.doi.org/10.1016/j.diagmicrobio. 2005.02.010. (Pubitemid 40826941)
13. Burgess DS. 2005. Use of pharmacokinetics and pharmacodynamics to optimize antimicrobial treatment of Pseudomonas aeruginosa infections. Clin. Infect. Dis. 40(Suppl 2):S99-S104. http://dx.doi.org/10.1086/426189. (Pubitemid 40270207)
14. Tam VH, Schilling AN, Neshat S, Poole K, Melnick DA, Coyle EA. 2005. Optimization of meropenemminimumconcentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 49:4920-4927. http://dx.doi.org/10.1128/AAC.49.12.4920-4927.2005. (Pubitemid 41778901)
15. Palmer KL, Aye LM, Whiteley M. 2007. Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum. J. Bacteriol. 189:8079-8087. http://dx.doi.org/10.1128/JB.01138-07. (Pubitemid 350178919)
16. Clinical and Laboratory Standards Institute. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 6th ed. Approved standard M7-A6. Clinical and Laboratory Standards Institute, Wayne, PA.
17. Strauss MP, Liew AT, Turnbull L, Whitchurch CB, Monahan LG, Harry EJ. 2012. 3D-SIM super resolution microscopy reveals a bead-like arrangement for FtsZ and the division machinery: implications for triggering cytokinesis. PLoS Biol. 10:e1001389. http://dx.doi.org/10.1371/journal.pbio.1001389.
18. Gustafsson MG, Shao L, Carlton PM, Wang CJ, Golubovskaya IN, Cande WZ, Agard DA, Sedat JW. 2008. Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophys. J. 94:4957-4970. http://dx.doi.org/10.1529/biophysj.107.120345.
19. Watanakunakorn C, Hamburger M. 1969. Induction of spheroplasts of Pseudomonas aeruginosa by carbenicillin. Appl. Microbiol. 17:935-937.
20. Justice SS, Hunstad DA, Cegelski L, Hultgren SJ. 2008. Morphological plasticity as a bacterial survival strategy. Nat. Rev. Microbiol. 6:162-168. http://dx.doi.org/10.1038/nrmicro1820.
21. Fjell CD, Hiss JA, Hancock RE, Schneider G. 2012. Designing antimicrobial peptides: form follows function. Nat. Rev. Drug Discov. 11:37-51. http://dx.doi.org/10.1038/nrd359110.1038/nrd3591.
22. Hancock REW, Nijnik A, Philpott DJ. 2012. Modulating immunity as a therapy for bacterial infections. Nat. Rev. Microbiol. 10:243-254. http://dx.doi.org/10.1038/nrmicro2745.
23. Kapoor R, Wadman MW, Dohm MT, Czyzewski AM, Spormann AM, Barron AE. 2011. Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms. Antimicrob. Agents Chemother. 55:3054-3057. http://dx.doi.org/10.1128/AAC.01516- 10.
24. Wright GD. 2012. Antibiotics: a new hope. Chem. Biol. 19:3-10. http://dx .doi.org/10.1016/j.chembiol.2011.10.019.
25. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48:1-12. http://dx.doi.org/10.1086/595011.
26. Piddock LJ. 2012. The crisis of no new antibiotics - what is the way forward? Lancet Infect. Dis. 12:249-253. http://dx.doi.org/10.1016/S1473- 3099(11)70316-4.
27. Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. 2011. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat. Chem. Biol. 7:348-350. http://dx.doi.org/10.1038/ nchembio.559.
28. Lehar J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF, 3rd, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT. 2007. Chemical combination effects predict connectivity in biological systems. Mol. Syst. Biol. 3:80. http://dx.doi.org/10.1038/msb4100116.
29. Sharom JR, Bellows DS, Tyers M. 2004. From large networks to small molecules. Curr. Opin. Chem. Biol. 8:81-90. http://dx.doi.org/10.1016/j.cbpa. 2003.12.007. (Pubitemid 38201482)
30. Walsh C. 2000. Molecular mechanisms that confer antibacterial drug resistance. Nature 406:775-781. http://dx.doi.org/10.1038/35021219.
31. Mesaros N, Nordmann P, Plesiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, Van Laethem Y, Jacobs F, Lebecque P, Malfroot A, Tulkens PM, Van Bambeke F. 2007. Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium. Clin. Microbiol. Infect. 13:560-578. http://dx.doi.org/10.1111/j.1469-0691.2007.01681.x. (Pubitemid 46730662)
32. Watanakunakorn C, Phair JP, Hamburger M. 1970. Increased resistance of Pseudomonas aeruginosa to carbenicillin after reversion from spheroplast to rod form. Infect. Immun. 1:427-430.
33. Ryall B, Eydallin G, Ferenci T. 2012. Culture history and population heterogeneity as determinants of bacterial adaptation: the adaptomics of a single environmental transition. Microbiol. Mol. Biol. Rev. 76:597-625. http://dx.doi.org/10.1128/MMBR.05028-11.