Silencing of CXCR4 inhibits tumor cell proliferation and neural invasion in human hilar cholangiocarcinoma

Gut and Liver

Volumn 8, Issue 2, 2014, Pages 196-204

  Tan, Xin Yu ^a   Chang, Shi ^a   Liu, Wei ^a   Tang, Hui Huan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CXCR4; Hilar cholangiocarcinoma; Neural invasion; RNA interference

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; P21 ACTIVATED KINASE; PROTEIN P53; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER METASTASIS; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR INVASION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BILE DUCT TUMOR; CASE CONTROL STUDY; INTRAHEPATIC BILE DUCT; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR RECURRENCE;

AGED; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; RECEPTORS, CXCR4; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84896922253     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2014.8.2.196     Document Type: Article

References (28)

1. Carriaga MT, Henson DE. Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer 1995;75(1 Suppl):171-190.
2. Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis 2004;24:115-125. (Pubitemid 38738341)
3. DeOliveira ML, Cunningham SC, Cameron JL, et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 2007;245:755-762. (Pubitemid 46684105)
4. Ramacciato G, Nigri G, Bellagamba R, et al. Univariate and multivariate analysis of prognostic factors in the surgical treatment of hilar cholangiocarcinoma. Am Surg 2010;76:1260-1268.
5. Zhang BY, Lu Y, Dong Q, Sun CD, Mu P. Surgical treatment and prognostic analysis of 93 cases of hilar cholangiocarcinoma. Am J Med Sci 2010;339:221-224.
6. Nguyen KT, Steel J, Vanounou T, et al. Initial presentation and management of hilar and peripheral cholangiocarcinoma: is a node-positive status or potential margin-positive result a contraindication to resection? Ann Surg Oncol 2009;16:3308-3315.
7. Shen FZ, Zhang BY, Feng YJ, et al. Current research in perineural invasion of cholangiocarcinoma. J Exp Clin Cancer Res 2010;29:24.
8. Zhu Z, Kleeff J, Kayed H, et al. Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells. Mol Carcinog 2002;35:138-147. (Pubitemid 35266060)
9. Bhuiya MR, Nimura Y, Kamiya J, et al. Clinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg 1992;215:344-349.
10. Schreiber SC, Giehl K, Kastilan C, et al. Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells. Gastroenterology 2008;134:1555-1566. (Pubitemid 351615366)
11. Gleichmann M, Gillen C, Czardybon M, et al. Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system. Eur J Neurosci 2000;12:1857-1866. (Pubitemid 30348825)
12. Katayama A, Ogino T, Bandoh N, Nonaka S, Harabuchi Y. Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinoma. Clin Cancer Res 2005;11:2937-2946. (Pubitemid 40525196)
13. Uchida D, Begum NM, Tomizuka Y, et al. Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma. Lab Invest 2004;84:1538-1546. (Pubitemid 39600561)
14. Marchesi F, Monti P, Leone BE, et al. Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res 2004;64:8420-8427. (Pubitemid 39491782)
15. Leelawat K, Leelawat S, Narong S, Hongeng S. Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. World J Gastroenterol 2007;13:1561-1568. (Pubitemid 46672665)
16. Yu J, Qiu L, Ma J, Huang Q, Ren Y. Analysis of factors influencing prognosis of patients underwent hilar carcinoma without resection. J Hepatobiliary Surg 2008;(4):281-283.
17. Ku JL, Yoon KA, Kim IJ, et al. Establishment and characterisation of six human biliary tract cancer cell lines. Br J Cancer 2002;87:187-193.
18. Mendoza M, Khanna C. Revisiting the seed and soil in cancer metastasis. Int J Biochem Cell Biol 2009;41:1452-1462.
19. Holland JD, Kochetkova M, Akekawatchai C, Dottore M, Lopez A, McColl SR. Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells. Cancer Res 2006;66:4117-4124.
20. Wang SC, Lin JK, Wang HS, Yang SH, Li AF, Chang SC. Nuclear expression of CXCR4 is associated with advanced colorectal cancer. Int J Colorectal Dis 2010;25:1185-1191.
21. Okamoto K, Tajima H, Nakanuma S, et al. Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Int J Oncol 2012;41:573-582.
22. Ouyang L, Shi Z, Zhao S, et al. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012;45:487-498.
23. Chinni SR, Sivalogan S, Dong Z, et al. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. Prostate 2006;66:32-48. (Pubitemid 43005947)
24. Ben QW, Wang JC, Liu J, et al. Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ann Surg Oncol 2010;17:2213-2221.
25. Zhao BC, Wang ZJ, Mao WZ, et al. CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. World J Gastroenterol 2011;17:2389-2396.
26. Katayama A, Ogino T, Bandoh N, Nonaka S, Harabuchi Y. Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinoma. Clin Cancer Res 2005;11:2937-2946. (Pubitemid 40525196)
27. Barbieri F, Bajetto A, Florio T. Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target. J Oncol 2010;2010:426956.
28. Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010;16:2927-2931.