Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice

Clinical Toxicology

Volumn 52, Issue 3, 2014, Pages 176-180

  Dargan, P I ^a,b   Tang, H C ^c   Liang, W ^c   Wood, D M ^a,b   Yew, D T ^c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bladder; Chronic toxicity; Ketamine analogue; Kidney; Methoxetamine; Novel psychoactive substances; Recreational drug

Indexed keywords

CD4 ANTIBODY; CD4 ANTIGEN; KETAMINE; METHOXETAMINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER DISEASE; BLADDER TOXICITY; CELL DEGENERATION; CELL DENSITY; CELL INFILTRATION; CONTROLLED STUDY; GLOMERULAR DYSFUNCTION; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; INFLAMMATORY CELL; KIDNEY TUBULE NECROSIS; LAMINA PROPRIA; MALE; MONONUCLEAR CELL; MOUSE; NEPHROTOXICITY; NONHUMAN; SUBMUCOSA;

ANIMALS; CYCLOHEXANONES; CYCLOHEXYLAMINES; KIDNEY; MALE; MICE; MICE, INBRED ICR; TIME FACTORS; URINARY BLADDER;

EID: 84896900221     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2014.892605     Document Type: Article

References (26)

1. G ibbons S. ' L egal highs'-n ovel and emerging psychoactive drugs: A chemical overview for the toxicologist. Clin Toxicol (Phila) 2012 ; 50 : 15-24
2. EMCDDA-Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA. Available at: Http://www.emcdda.europa. eu/attachements.cfm/att-132857-EN-EMCDDA-Europol%20 Annual%20Report%202010A.pdf. Accessed on 16 December 2013
3. Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. The ketamine analogue methoxetamine and 3- And 4-methoxy analogues of phencyclidine are high affi nity and selective ligands for the glutamate NMDA receptor. PLos One 2013; 8 : E59334
4. 2012 Global Drug Survey. Available at: Http://www.globaldrugsurvey. com/run-my-survey/2012-global-drug-survey. Accessed on 16 December 2013
5. W ood D M, H unter L, M easham F, D argan P I. L imited use of novel psychoactive substances in South London nightclubs. QJM 2012 ; 105 : 959-964
6. A rcher J R, D argan P I, C han W L, H itchings A, H udson S, W ood D M. Trend analysis of novel psychoactive substances detected in pooled urine samples from street urinals over six months. Clin Toxicol (Phila) 2013; 51 : 666
7. Wood DM, Archer JRH, Measham F, Hudson S, Dargan PI. Detection of use of novel psychoactive substances by attendees at a music festival in the North West of England. Clin Toxicol (Phila) 2013; 51: 340- 341
8. Archer JR, Dargan PI, Hudson S, Wood DM. Analysis of anonymous pooled urine from portable urinals in central London confi rms the significant use of novel psychoactive substances. Q JM 2 013; 1 06: 1 47- 1 52
9. W ard J, R hyee S, P lansky J, B oyer E. M ethoxetamine: A novel ketamine analog and growing health-care concern. Clin Toxicol (Phila) 2011 ; 49 : 874-875
10. H ofer K E, G rager B, M ü l ler D M, R auber-Lü t hy C, K upferschmidt H, Rentsch KM, Ceschi A. Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med 2012 ; 60 : 97-99
11. W ood D M, D avies S, P uchnarewicz M, J ohnston A, D argan P I. A cute toxicity associated with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol 2012 ; 68 : 853-856
12. S hields J E, D argan P I, W ood D M, P uchnarewicz M, D avies S, Waring S. Methoxetamine associated cerebellar toxicity: Three cases with analytical confi rmation. Clin Toxicol (Phila) 2012 ; 50 : 438-440
13. Yeung LY, Rudd JA, Lam WP, Mak YT, Yew DT. Mice are prone to kidney pathology after prolonged ketamine addiction. Toxicol Lett 2009 ; 191 : 275-278
14. Tan S, Chan WM, Wai MS, Hui LK, Hui VW, James AE, et al. Ketamine effects on the urogenital system-changes in the urinary bladder and sperm motility. Microsc Res Tech 2011 ; 74 : 1192-1198
15. Wai MS, Chan WM, Zhang AQ, Wu Y, Yew DT. Long-Term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney. Hum Exp Toxicol 2012 ; 31 : 877-886
16. Chu PS, Kwok SC, Lam KM, Chu TY, Chan SW, Man CW, Ma WK. ' Street ketamine ' -Associated bladder dysfunction: A report of ten cases . Hong Kong Med J 2007 ; 13 : 311-313
17. Tsai TH, Cha TL, Lin CM, Tsao CW, Tang SH, Chuang FP, et al. Ketamine-Associated bladder dysfunction. Int J Urol 2009 ; 16 : 826-829
18. Morris H (11-February-2011). Interview with a ketamine chemist: Or to be more precise, an arylcyclohexylamine chemist. Vice Magazine. Available at: Http://www.vice.com/read/interview-with-ketaminechemist-704-v18n2. Accessed on 16 December 2013
19. Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the Internet: The case of ketamine derivative methoxetamine. Hum Psychopharmacol 2012 ; 27 : 145-149
20. C hu P S, M a W K, W ong S CW, C hu R WH, C heng C H, W ong S, e t a l. The destruction of the lower urinary tract by ketamine abuse: A new syndrome?. BJU Int 2008 ; 102 : 1616-1622
21. Andersson KE, Arner A. Urinary bladder contraction and relaxation: Physiology and pathophysioogy. Physiol Rev 2004 ; 84 : 935-986
22. Poon TL, Wong KF, Chan MY, Fung KW, Chu SK, Man CW, et al. Upper gastrointestinal problems in inhalational ketamine abusers. J Dig Dis 2010 ; 11 : 106-110
23. Wong SW, Lee KF, Wong J, Ng WW, Cheung YS, Lai PB. Dilated common bile ducts mimicking choledochal cysts in ketamine abusers. Hong Kong Med J 2009 ; 15 : 53-56
24. Morgan CJ, Curran HV. Acute and chronic effects of ketamine upon human memory: A review. Psychopharmacol [Berl] 2006 ; 188 : 408-424
25. Liao Y, Tang J, Ma M, Wu Z, Yang M, Wang X, et al. Frontal white matter abnormalities following chronic ketamine use: A diffusion tensor imaging study. Brain 2010 ; 133 : 2115-2122
26. E dward Roberts R, C urran H V, F riston K J, M organ C J. A bnormalities in white matter microstructure associated with chronic ketamine use. Neuropsychopharmacology 2014 ; 39 : 329-338