Long-term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney

Human and Experimental Toxicology

Volumn 31, Issue 9, 2012, Pages 877-886

  Wai, M S M ^a   Chan, W M ^a   Zhang, A Q ^b   Wu, Y ^c   Yew, D T ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

alcohol; ketamine; kidney; liver; side effects; toxicology

Indexed keywords

ALCOHOL; ASPARTATE AMINOTRANSFERASE; CYCLINE; KETAMINE; LACTATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG USE; ENZYME LOCALIZATION; GLOMERULUS; GLOMERULUS ATRESIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY TUBULE; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER CELL; LIVER FATTY DEGENERATION; LIVER FIBROSIS; LIVER FUNCTION TEST; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA;

ANESTHETICS, DISSOCIATIVE; ANIMALS; ASPARTATE AMINOTRANSFERASES; DRUG SYNERGISM; ETHANOL; KETAMINE; KIDNEY; L-LACTATE DEHYDROGENASE; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED ICR; PROTEINURIA;

ANIMALIA; MUS;

EID: 84865404834     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327112436404     Document Type: Article

References (26)

1. Annetta MG, Iemma D, Garisto C, Tafani C, Proietti R. Ketamine: new indications for an old drug. Curr Drug Targets. 2005 ; 6: 789-794
2. Bhutta AT. Ketamine: a controversial drug for neonates. Semin Perinatol. 2007 ; 31: 303-308
3. Persson J. Wherefore ketamine?. Curr Opin Anaesthesiol. 2010 ; 23: 455-460
4. Report TIB, Narcotics Division, Security Bureau, Hong Kong Government, http://www.nd.gov.hk/
5. Hopcroft SA, Cottrell AM, Mason K, Abrams P, Oxley JD. Ureteric intestinal metaplasia in association with chronic recreational ketamine abuse. J Clin Pathol. 2011 ; 64: 551-552
6. Meyer MR, Maurer HH. Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse. Pharmacogenomics. 2011 ; 12: 215-233
7. Wilkins LK, Girard TA, Cheyne JA. Ketamine as a primary predictor of out-of-body experiences associated with multiple substance use. Conscious Cogn. 2011 ; 20: 943-950
8. Sun L, Lam WP, Wong YW, Lam LH, Tang HC, Wai MS, et al. Permanent deficits in brain functions caused by long-term ketamine treatment in mice. Hum Exp Toxicol. 2010 ; 30: 1287-1296
9. Yeung LY, Wai MS, Fan M, Mak YT, Lam WP, Li Z, et al. Hyperphosphorylated tau in the brains of mice and monkeys with long-term administration of ketamine. Toxicol Lett. 2010 ; 193: 189-193
10. Chan WM, Xu J, Fan M, Tsui YM, Wai SM, Lam WP, et al. Downregulation in the human and mice cerebella after ketamine versus ketamine plus ethanol treatment. Microsc Res Tech. 2011 ;:
11. Yeung LY, Rudd JA, Lam WP, Mak YT, Yew DT. Mice are prone to kidney pathology after prolonged ketamine addiction. Toxicol Lett. 2009 ; 191: 275-278
12. Tan S, Chan WM, Wai MS, Hui LK, Hui VW, James AE, et al. Ketamine effects on the urogenital system-changes in the urinary bladder and sperm motility. Microsc Res Tech. 2011 ; 74: 1192-1198
13. Trouton TG, Allen JD, Young IS, Trimble ER, Adgey AA. Altered cardiac oxygen extraction, lactate production and coronary blood flow after large dose transthoracic DC countershocks. Pacing Clin Electrophysiol. 1993 ; 16: 1304-1309
14. Zhao R, Fang SH, Lin KN, Huang XQ, Lu YB, Zhang WP, et al. Pranlukast attenuates hydrogen peroxide-induced necrosis in endothelial cells by inhibiting oxygen reactive species-mediated collapse of mitochondrial membrane potential. J Cardiovasc Pharmacol. 2011 ; 57: 479-488
15. Wai MS, Jiang YL, Chan WM, Tsui YM, Tang HC, Lam WP, et al. Long term ketamine and ketamine plus alcohol toxicity-what can we learn from animal models?. Mini Rev Med Chem. 2011 ;:
16. Madej JA, Staczyk JF. Effect of ketamine anaesthesia on enzyme activity in organs of dogs and cats. Anaesth Resuscitation Intensive Ther. 1975 ; 3: 297-303
17. Chan WH, Sun WZ, Ueng TH. Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. J Toxicol Environ Health. 2005 ; 68: 1581-1597
18. Rofael HZ. Effect of ketamine pretreatment on cocaine-mediated hepatotoxicity in rats. Toxicol Lett. 2004 ; 152: 213-222
19. Helmer KS, Cui Y, Dewan A, Mercer DW. Ketamine/xylazine attenuates LPS-induced iNOS expression in various rat tissues. J Surg Res. 2003 ; 112: 70-78
20. Suliburk JW, Ward JL, Helmer KS, Adams SD, Zuckerbraun BS, Mercer DW. Ketamine-induced hepatoprotection: the role of heme oxygenase-1. Am J Physiol Gastrointest Liver Physiol. 2009 ; 296: G1360 - G1369
21. Suliburk JW, Gonzalez EA, Kennison SD, Helmer KS, Mercer DW. Differential effects of anesthetics on endotoxin-induced liver injury. J Trauma. 2005 ; 58: 711-717
22. Sear JW. Ketamine hepato-toxicity in chronic pain management: another example of unexpected toxicity or a predicted result from previous clinical and pre-clinical data?. Pain. 2011 ; 152: 1946-1947
23. Niesters M, Dahan A, Swartjes M, Noppers I, Fillingim RB, Aarts L, et al. Effect of ketamine on endogenous pain modulation in healthy volunteers. Pain. 2011 ; 152: 656-663
24. Zou X, Patterson TA, Sadovova N, Twaddle NC, Doerge DR, Zhang X, et al. Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci. 2009 ; 108: 149-158
25. Alfonso-Loeches S, Guerri C. Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit Rev Clin Lab Sci. 2011 ; 48: 19-47
26. Sorce S, Schiavone S, Tucci P, Colaianna M, Jaquet V, Cuomo V, et al. The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses. J Neurosci. 2010 ; 30: 11317-11325