Imaging evaluation of 5HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization

Journal of Medicinal Chemistry

Volumn 57, Issue 4, 2014, Pages 1488-1494

  Neelamegam, Ramesh ^a   Hellenbrand, Tim ^b   Schroeder, Frederick A ^a   Wang, Changning ^a   Hooker, Jacob M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,8,9,10,10A OCTAHYDRO 7BH CYCLOPENTA[B][1,4]DIAZEPINO[6,7,1 HI]INDOLE; CARBON 11; FORMALDEHYDE; N,N DIMETHYLFORMAMIDE; VABICASERIN; 1,2,3,4,8,9,10,10A-OCTAHYDRO-7BH-CYCLOPENTA(B)(1,4)DIAZEPINO(6,7,1HJ)INDOLE; 1,2,3,4,8,9,10,10A OCTAHYDRO 7BH CYCLOPENTA(B)(1,4)DIAZEPINO(6,7,1HJ)INDOLE; AZEPINE DERIVATIVE; CARBON; FUSED HETEROCYCLIC RINGS; INDOLE DERIVATIVE; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CYCLIZATION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG STRUCTURE; HIGH TEMPERATURE; IMAGE ANALYSIS; ISOTOPE LABELING; NONHUMAN; PAPIO ANUBIS; PICTET SPENGLER REACTION; POSITRON EMISSION TOMOGRAPHY; CHEMISTRY;

AZEPINES; CARBON RADIOISOTOPES; CYCLIZATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INDOLES; POSITRON-EMISSION TOMOGRAPHY; SEROTONIN RECEPTOR AGONISTS;

EID: 84896894888     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401802f     Document Type: Article

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