Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification

Journal of Medicinal Chemistry

Volumn 57, Issue 4, 2014, Pages 1378-1389

  Sit, Rakesh K ^a   Fokin, Valery V ^a   Amitai, Gabriel ^b   Sharpless, K Barry ^a   Taylor, Palmer ^c   Radić, Zoran ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (PENT 4 EN 1 YL) IMIDAZOLE 2 CARBALDEHYDE OXIME; 1 ISOPENTYLIMIDAZOLE 2 CARBALDEHYDE OXIME; 1 NONYLIMIDAZOLE 2 CARBALDEHYDE OXIME; 1(3 AZIDOBUTYL) IMIDAZOLE 2 CARBALDEHYDE OXIME; 1(3 AZIDOPROPYL) IMIDAZOLE 2 CARBALDEHYDE OXIME; 1(3 PHENYLPROPYL) IMIDAZOLE 2 CARBALDEHYDE OXIME; 1(3 PROP 2 YN 1 YL) IMIDAZOLE 2 CARBALDEHYDE OXIME; 1(3,3 DIMETHYLBUTYL) IMIDAZOLE 2 CARBALDEHYDE OXIME; ACETYLCHOLINESTERASE; ALDOXIME; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; IMIDAZOLE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHATE; PARAOXON; SARIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITION; DETOXIFICATION; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME REACTIVATION; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

BUTYRYLCHOLINESTERASE; CATALYSIS; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES;

EID: 84896889071     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401650z     Document Type: Article

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