Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 343-351

  Hinsberger, Stefan ^a   De Jong, Johannes C ^a   Groh, Matthias ^a   Haupenthal, Jörg ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Benzamidobenzoic acid; PqsD inhibitor; PqsD selectivity; Pseudomonas aeruginosa; RNA polymerase inhibitor

Indexed keywords

2 [(1,1' BIPHENYL) 4 YLSULFUONAMIDO] 5 BROMOBENZOIC ACID; 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 4 BROMOBENZOIC ACID; 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 BROMOBENZOIC ACID; 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]5 PHENYLTHIOPHENE 2 CARBOXYLIC ACID; 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]BENZOIC ACID; 4 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]BENZOIC ACID; 4 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]THIOPHENE 3 CARBOXYLIC ACID; BENZAMIDOBENZOIC ACID; BENZOIC ACID DERIVATIVE; ENZYME; ETHYL 2 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 PHENYLTHIOPHENE 3 CARBOXYLIC ACID; ETHYL 2 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]THIOPHENE 3 CARBOXYLIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 4 BROMOBENZOIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 (4 CHLOROPHENYL)THIOPHENE 2 CARBOXYLIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 (4 METHOXYPHENYL)THIOPHENE 2 CARBOXYLIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 BROMOBENZOIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO] 5 PHENYLTHIOPHENE 2 CARBOXYLIC ACID; METHYL 3 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]THIOPHENE 2 CARBOXYLIC ACID; METHYL 3 [(1,1'BIPHENYL) 4 YLCARBOXAMIDO]BENZOIC ACID; METHYL 3 AMINO 4 BROMOBENZOIC ACID; METHYL 3 AMINO 5 BROMOBENZOIC ACID; METHYL 3 AMINOBENZOIC ACID; METHYL 4 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]BROMOBENZOIC ACID; METHYL 4 [(1,1' BIPHENYL) 4 YLCARBOXAMIDO]THIOPHENE 3 CARBOXYLIC ACID; METHYL 4 AMINOBENZOIC ACID; N (4 BROMO 2 CARBAMOYLPHENYL) [1,1' BIPHENYL] 4 CARBOXAMIDE; N (4 BROMO 2 CYANOPHENYL) [1,1' BIPHENYL] 4 CARBOXAMIDE; PQSD PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; STRUCTURE ACTIVITY RELATION; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; MICROBIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PSEUDOMONAS INFECTIONS;

ANTI-BACTERIAL AGENTS; BENZOATES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84896877636     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.014     Document Type: Article

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