The role of Interleukin-6, its -174 G>C polymorphism and C-reactive protein in idiopathic cardiac arrhythmias in children

Advances in Medical Sciences

Volumn 58, Issue 2, 2013, Pages 320-325

  Szydlowski, L ^a   Skierska, A ^a   Markiewicz Loskot, G ^a   Mazurek, B ^a   Morka, A ^a   Undas, A ^b  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Arrhythmia; C reactive protein; Children; Gene polymorphism; Interleukin 6

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEART ARRHYTHMIA; HEART SUPRAVENTRICULAR ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; HOLTER MONITORING; HUMAN; IDIOPATHIC DISEASE; IDIOPATHIC HEART ARRHYTHMIA; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; TRANSTHORACIC ECHOCARDIOGRAPHY;

ADOLESCENT; ARRHYTHMIAS, CARDIAC; ATRIAL FLUTTER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; TACHYCARDIA, SUPRAVENTRICULAR; TACHYCARDIA, VENTRICULAR; VENTRICULAR PREMATURE COMPLEXES;

EID: 84896871747     PISSN: 18961126     EISSN: 18984002     Source Type: Journal    
DOI: 10.2478/ams-2013-0003     Document Type: Article

References (29)

1. Vickers MA, Green FR, Terry C, Mayosi BM, Julier C, Lathrop M, Ratcliffe PJ, Watkins HC, Keavney B. Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc Res. 2002 Mar;53(4):1029-34.
2. Jones J, Chen LS, Baudhuin L, Peterson S, Harmsen WS, Zinsmeister AR, McConnell J, Sandborn WJ. Relationships between C-reactive protein concentration and genotype in healthy volunteers. Clin Chem Lab Med. 2009;47(1):20-5.
3. Kilpinen S, Hulkkonen J, Wang XY, Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Netw. 2001 Mar;12(1):62-8.
4. Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ. The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J. 2001 Dec;22(24):2243-52.
5. Potaczek DP, Undas A, Nowakowski T, Szczeklik A. Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease. Int Angiol. 2007 Dec;26(4):318-23.
6. Potaczek DP, Undas A, Celinska-Lowenhoff M, Szczeklik A. Interleukin-6 -174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients. Blood Coagul Fibrinolysis. 2006 Jan;17(1):35-8.
7. Antonicelli R, Olivieri F, Bonafè M, Cavallone L, Spazzafumo L, Marchegiani F, Cardelli M, Recanatini A, Testarmata P, Boemi M, Parati G, Franceschi C. The interleukin- 6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Int J Cardiol. 2005 Sep 1;103(3):266-71.
8. Jenny NS, Tracy RP, Ogg MS, Luong le A, Kuller LH, Arnold AM, Sharrett AR, Humphries SE. In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2066-71.
9. Sie MP, Sayed-Tabatabaei FA, Oei HH, Uitterlinden AG, Pols HA, Hofman A, van Duijn CM, Witteman JC. Interleukin 6 -174 g/c promoter polymorphism and risk of coronary heart disease: results from the rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):212-7.
10. Cheng T, Wang XF, Hou YT, Zhang L. Correlation between atrial fibrillation, serum amyloid protein A and other inflammatory cytokines. Mol Med Report. 2012 Sep;6(3):581-4.
11. Psychari SN, Chatzopoulos D, Iliodromitis EK, Apostolou TS, Kremastinos DT. C-reactive protein, interleukin 6, and N-terminal pro-brain natriuretic peptide following cardioversion of atrial fibrillation: is there a role of biomarkers in arrhythmia recurrence? Angiology. 2011 May;62(4):310-6.
12. Smit MD, Maass AH, De Jong AM, Muller Kobold AC, Van Veldhuisen DJ, Van Gelder IC. Role of inflammation in early atrial fibrillation recurrence. Europace. 2012 Jun;14(6):810-7.
13. Masson S, Aleksova A, Favero C, Staszewsky L, Bernardinangeli M, Belvito C, Cioffi G, Sinagra G, Mazzone C, Bertocchi F, Vago T, Peri G, Cuccovillo I, Masuda N, Barlera S, Mantovani A, Maggioni AP, Franzosi MG, Disertori M, Latini R; GISSI-AF investigators. Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in sinus rhythm at high risk for atrial fibrillation: data from the GISSI atrial fibrillation trial. Heart. 2010 Dec;96(23):1909-14.
14. Patel P, Dokainish H, Tsai P, Lakkis N. Update on the association of inflammation and atrial fibrillation. J Cardiovasc Electrophysiol. 2010 Sep;21(9):1064-70.
15. Marcus GM, Smith LM, Ordovas K, Scheinman MM, Kim AM, Badhwar N, Lee RJ, Tseng ZH, Lee BK, Olgin JE. Intracardiac and extracardiac markers of inflammation during atrial fibrillation. Heart Rhythm. 2010;7(2):149-54.
16. Li J, Solus J, Chen Q, Milne G, Stein CM, Darbar D. Role of inflammation and oxidative stress in atrial fibrillation. Heart Rhythm. 2010 Apr;7(4):438-44.
17. Shah SS, Hellenbrand WE, Gallagher PG. Atrial flutter complicating neonatal Coxsackie B2 myocarditis. Pediatr Cardiol. 1998 Mar-Apr;19(2):185-6.
18. Grosse-Wortmann L, Muehler EG. Myocardial ischaemia in a child infected with influenza B. Cardiol Young. 2005 Apr;15(2):226-8.
19. Abrams D, Derrick G, Penny DJ, Shinebourne EA, Redington AN. Cardiac complications in children following infection with varicella zoster virus. Cardiol Young. 2001 Now;11(6):647-52.
20. Steininger C, Holzmann H, Zwiauer KF, Popow-Kraupp T. Influenza A virus infection and cardiac arrhythmia during the neonatal period. Scand J Infect Dis. 2002;34(10):782-4.
21. Raza MW, Blackwell CC. Sudden infant death syndrome, virus infections and cytokines. FEMS Immunol Med Microbiol. 1999 Aug1;25(1-2):85-96.
22. Huang M, Bigos D, Levine M. Ventricular arrhythmia associated with respiratory syncytial viral infection. Pediatr Cardiol. 1998 Nov-Dec;19(6):498-500.
23. Schultz JC, Hilliard AA, Cooper LT, Rihal CS. Diagnosis and treatment of viral myocarditis. Mayo Clin Proc. 2009 Nov;84(11):1001-9.
24. Simpson KE, Hulse E, Carlson K. Atrial tachyarrhythmias in neonatal enterovirus myocarditis. Pediatr Cardiol. 2009 Aug;30(6):827-30.
25. Kühl U, Schultheiss HP. Myocarditis in children. Heart Fail Clin. 2010 Oct;6(4):483-96, viii-ix.
26. Kowalewski M, Urban M, Mroczko B, Szmitowski M. Cytokiny prozapalne (IL-6, TNF-?) i sercowa troponina I (cTnI) w surowicy mlodych osob z komorowymi zaburzeniami rytmu serca [Proinflammatory cytokines (IL-6, TNF-alpha) and cardiac troponin I (cTnI) in serum of young people with ventricular arrhythmias] Pol Arch Med Wewn. 2002 Jul;108(1):647-51. Polish.
27. Beaufort-Krol GC, Dijkstra SS, Bink-Boelkens MT. Natural history of ventricular premature contractions in children with a structurally normal heart: does origin matter? Europace. 2008 Aug;10(8):998-1003.
28. Wang JN, Wu JM, Tsai YC, Lin CS. Ectopic atrial tachycardia in children. J Formos Med Assoc. 2000 Oct;99(10):766-70.
29. Lefkou E, Fragakis N, Ioannidou E, Bounda A, Theodoridou S, Klonizakis P, Garipidou V. Increased levels of proinflammatory cytokines in children with family history of coronary artery disease. Clin Cardiol. 2010 Apr;33(4):E6-10.