Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

Cardiovascular Research

Volumn 53, Issue 4, 2002, Pages 1029-1034

  Vickers, Mark A ^a   Green, Fiona R ^b   Terry, Catherine ^b   Mayosi, Bongani M ^b   Julier, Cecile ^c   Lathrop, Mark ^d   Ratcliffe, Peter J ^e   Watkins, Hugh C ^b   Keavney, Bernard ^f,g  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUT PASTEUR   (France)

^d CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

^g INSTITUTE OF HUMAN GENETICS   (United Kingdom)

Author keywords

Atherosclerosis; Cytokines; Epidemiology; Infection inflammation; Sequence (DNA RNA prot)

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

ADULT; AGED; ALLELE; ARTICLE; CARDIOVASCULAR RISK; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; FAMILY STUDY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REFERENCE VALUES;

EID: 0036200247     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00534-X     Document Type: Article

References (24)

1. Low grade inflammation and coronary heart disease: Prospective study and updated meta-analyses
2. C-Reactive protein as a cardiovascular risk factor: More than an epiphenomenon?
3. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
4. Familial and genetic determinants of systemic markers of inflammation: The NHLBI family heart study
5. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
6. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms
7. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis
8. Interleukin-6 gene -174G/C and -572G/C promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery
9. The effect of interleukin-6 C/G-174 polymorphism and circulating interleukin-6 on fibrinogen plasma levels
10. Circadian characteristics of circulating interleukin-6 in men
11. Circadian interleukin-6 secretion and quantity and depth of sleep
12. Circadian interrelationships among levels of plasma fibrinogen, blood platelets, and serum interleukin-6
13. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects
14. Five-year intra-individual variability in C-reactive protein levels in a Japanese population-based study: The Jichi Medical School cohort study at Yamato, 1993-1998
15. Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
16. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
17. C-Reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
18. Genetic dissection of complex traits
19. PedCheck: A program for identification of genotype incompatibilities in linkage analysis
20. A general test of association for quantitative traits in nuclear families
21. Multipoint quantitative-trait linkage analysis in general pedigrees
22. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
23. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
24. Human C-reactive protein (CRP) 1059G/C polymorphism