An expeditious synthesis of the MDM2-p53 inhibitor AM-8553

Journal of the American Chemical Society

Volumn 134, Issue 30, 2012, Pages 12855-12860

  Lucas, Brian S ^a   Fisher, Benjamin ^a   McGee, Lawrence R ^a   Olson, Steven H ^a   Medina, Julio C ^a   Cheung, Eugene ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIASTEREOSELECTIVE; DYNAMIC KINETIC RESOLUTION; LOW-YIELD; P53 INHIBITORS; SECOND-GENERATION SYNTHESIS;

CHEMISTRY;

SYNTHESIS (CHEMICAL);

AM 8553; ANTINEOPLASTIC AGENT; OXAZOLINE DERIVATIVE; PIPERIDONE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ALLYLATION; ARTICLE; DRUG SYNTHESIS; STEREOCHEMISTRY;

ACETATES; AMINO ALCOHOLS; ANTINEOPLASTIC AGENTS; CYCLIZATION; HUMANS; LACTONES; MODELS, MOLECULAR; OXAZOLES; PIPERIDONES; PROTO-ONCOGENE PROTEINS C-MDM2; STEREOISOMERISM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864478361     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja305123v     Document Type: Article

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