메뉴 건너뛰기




Volumn 4, Issue , 2014, Pages

Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4;

EID: 84896788794     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04290     Document Type: Article
Times cited : (15)

References (63)
  • 1
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden, D. T. The stem-cell niche as an entity of action. Nature 441, 1075-1079 (2006).
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 2
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
    • Morrison, S. J. &Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132, 598-611 (2008).
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 3
    • 1642603951 scopus 로고    scopus 로고
    • Socializing with the neighbors: Stem cells and their niche
    • Fuchs, E., Tumbar, T. and Guasch, G. Socializing with the neighbors: stem cells and their niche. Cell 116, 769-778 (2004).
    • (2004) Cell , vol.116 , pp. 769-778
    • Fuchs, E.1    Tumbar, T.2    Guasch, G.3
  • 4
    • 84871603152 scopus 로고    scopus 로고
    • Adhesion in the stem cell niche: Biological roles and regulation
    • Chen, S., Lewallen, M. and Xie, T. Adhesion in the stem cell niche: biological roles and regulation. Development 140, 255-265 (2013).
    • (2013) Development , vol.140 , pp. 255-265
    • Chen, S.1    Lewallen, M.2    Xie, T.3
  • 5
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • Li, L. and Neaves, W. B. Normal stem cells and cancer stem cells: the niche matters. Cancer Res 66, 4553-4557 (2006).
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 6
    • 34247226529 scopus 로고    scopus 로고
    • Gene function in mouse embryogenesis: Get set for gastrulation
    • Tam, P. P. L. and Loebel, D. A. F. Gene function in mouse embryogenesis: get set for gastrulation. Nat Rev Genet 8, 368-381 (2007).
    • (2007) Nat Rev Genet , vol.8 , pp. 368-381
    • Tam, P.P.L.1    Loebel, D.A.F.2
  • 7
    • 0027282962 scopus 로고
    • The role of E-cadherin and integrins inmesoderm differentiation and migration at the mammalian primitive streak
    • Burdsal, C. A., Damsky, C. H. and Pedersen, R. A. The role of E-cadherin and integrins inmesoderm differentiation and migration at the mammalian primitive streak. Development 118, 829-844 (1993).
    • (1993) Development , vol.118 , pp. 829-844
    • Burdsal, C.A.1    Damsky, C.H.2    Pedersen, R.A.3
  • 8
    • 0035408007 scopus 로고    scopus 로고
    • FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    • Ciruna, B. and Rossant, J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell 1, 37-49 (2001).
    • (2001) Dev Cell , vol.1 , pp. 37-49
    • Ciruna, B.1    Rossant, J.2
  • 9
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. J. and Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 10
    • 0038410006 scopus 로고    scopus 로고
    • How we are shaped: The biomechanics of gastrulation
    • Keller, R., Davidson, L. A.& Shook, D. R. How we are shaped: the biomechanics of gastrulation. Differentiation 71, 171-205 (2003).
    • (2003) Differentiation , vol.71 , pp. 171-205
    • Keller, R.1    Davidson, L.A.2    Shook, D.R.3
  • 11
    • 84867298752 scopus 로고    scopus 로고
    • Forces driving epithelial spreading in zebrafish gastrulation
    • Behrndt, M. et al. Forces driving epithelial spreading in zebrafish gastrulation. Science 338, 257-260 (2012).
    • (2012) Science , vol.338 , pp. 257-260
    • Behrndt, M.1
  • 12
    • 43149088966 scopus 로고    scopus 로고
    • Tensile forces govern germ-layer organization in zebrafish
    • Krieg, M. et al. Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol 10, 429-436 (2008).
    • (2008) Nat Cell Biol , vol.10 , pp. 429-436
    • Krieg, M.1
  • 13
    • 79951838018 scopus 로고    scopus 로고
    • Punctuated actin contractions during convergent extension and their permissive regulation by the non-canonical Wnt-signaling pathway
    • Kim, H. Y. and Davidson, L. A. Punctuated actin contractions during convergent extension and their permissive regulation by the non-canonical Wnt-signaling pathway. J Cell Sci 124, 635-646 (2011).
    • (2011) J Cell Sci , vol.124 , pp. 635-646
    • Kim, H.Y.1    Davidson, L.A.2
  • 14
    • 64549110806 scopus 로고    scopus 로고
    • Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure
    • Zhou, J., Kim, H. Y. and Davidson, L. A. Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure. Development 136, 677-688 (2009).
    • (2009) Development , vol.136 , pp. 677-688
    • Zhou, J.1    Kim, H.Y.2    Davidson, L.A.3
  • 15
    • 29044448970 scopus 로고    scopus 로고
    • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure
    • Franke, J. D., Montague, R. A. and Kiehart, D. P. Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. Curr Biol 15, 2208-2221 (2005).
    • (2005) Curr Biol , vol.15 , pp. 2208-2221
    • Franke, J.D.1    Montague, R.A.2    Kiehart, D.P.3
  • 16
    • 33947095101 scopus 로고    scopus 로고
    • Model for the regulation of size in the wing imaginal disc of Drosophila
    • Aegerter-Wilmsen, T., Aegerter, C. M., Hafen, E. and Basler, K. Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev 124, 318-326 (2007).
    • (2007) Mech Dev , vol.124 , pp. 318-326
    • Aegerter-Wilmsen, T.1    Aegerter, C.M.2    Hafen, E.3    Basler, K.4
  • 17
    • 79851473886 scopus 로고    scopus 로고
    • A high-resolution anatomical atlas of the transcriptome in the mouse embryo
    • Diez-Roux, G. et al. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol 9, e1000582 (2011).
    • (2011) PLoS Biol , vol.9
    • Diez-Roux, G.1
  • 18
    • 58049220350 scopus 로고    scopus 로고
    • Mechanotransduction in development: A growing role for contractility
    • Wozniak, M. A. and Chen, C. S. Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol 10, 34-43 (2009).
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 34-43
    • Wozniak, M.A.1    Chen, C.S.2
  • 20
    • 78650833739 scopus 로고    scopus 로고
    • Surprisingly simple mechanical behavior of a complex embryonic tissue
    • Dassow, von, M., Strother, J. A. &Davidson, L. A. Surprisingly simple mechanical behavior of a complex embryonic tissue. PLoS ONE 5, e15359 (2010).
    • (2010) PLoS ONE , vol.5
    • Von, D.M.1    Strother, J.A.2    Davidson, L.A.3
  • 21
    • 34249283103 scopus 로고    scopus 로고
    • Embryonic stem-cell culture as a tool for developmental cell biology
    • Nishikawa, S.-I., Jakt, L. M. and Era, T. Embryonic stem-cell culture as a tool for developmental cell biology. Nat Rev Mol Cell Biol 8, 502-507 (2007).
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 502-507
    • Nishikawa, S.-I.1    Jakt, L.M.2    Era, T.3
  • 22
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry, C. E. and Keller, G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661-680 (2008).
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 23
    • 67649920749 scopus 로고    scopus 로고
    • Growth factors, matrices, and forces combine and control stem cells
    • Discher, D. E., Mooney, D. J. and Zandstra, P. W. Growth factors, matrices, and forces combine and control stem cells. Science 324, 1673-1677 (2009).
    • (2009) Science , vol.324 , pp. 1673-1677
    • Discher, D.E.1    Mooney, D.J.2    Zandstra, P.W.3
  • 24
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler, A. J., Sen, S., Sweeney, H. L. and Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677-689 (2006).
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 25
    • 77949777103 scopus 로고    scopus 로고
    • Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation
    • Shukla, S. et al. Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. J Histochem Cytochem 58, 345-358 (2010).
    • (2010) J Histochem Cytochem , vol.58 , pp. 345-358
    • Shukla, S.1
  • 26
    • 84874417846 scopus 로고    scopus 로고
    • Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size
    • Kinney, M. A., Saeed, R. &McDevitt, T. C. Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol 4, 641-650 (2012).
    • (2012) Integr Biol , vol.4 , pp. 641-650
    • Kinney, M.A.1    Saeed, R.2    McDevitt, T.C.3
  • 27
    • 0028970392 scopus 로고
    • Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development
    • Johansson, B. M. &Wiles, M. V. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 15, 141-151 (1995).
    • (1995) Mol Cell Biol , vol.15 , pp. 141-151
    • Johansson, B.M.1    Wiles, M.V.2
  • 28
    • 0035880235 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro
    • Li, F., Lu, S., Vida, L., Thomson, J. A. and Honig, G. R. Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro. Blood 98, 335-342 (2001).
    • (2001) Blood , vol.98 , pp. 335-342
    • Li, F.1    Lu, S.2    Vida, L.3    Thomson, J.A.4    Honig, G.R.5
  • 29
    • 0037405501 scopus 로고    scopus 로고
    • Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
    • Masszi, A. et al. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 284, F911-24 (2003).
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Masszi, A.1
  • 30
    • 52049119029 scopus 로고    scopus 로고
    • Embryoid body morphology influences diffusive transport of inductive biochemicals: A strategy for stem cell differentiation
    • Sachlos, E. and Auguste, D. T. Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation. Biomaterials 29, 4471-4480 (2008).
    • (2008) Biomaterials , vol.29 , pp. 4471-4480
    • Sachlos, E.1    Auguste, D.T.2
  • 31
    • 77957227956 scopus 로고    scopus 로고
    • A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo
    • sup 1-11
    • Kardash, E. et al. A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol 12, 47-53- sup pp 1-11 (2010).
    • (2010) Nat Cell Biol , vol.12 , pp. 47-53
    • Kardash, E.1
  • 32
    • 0034017744 scopus 로고    scopus 로고
    • Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
    • Ishizaki, T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57, 976-983 (2000).
    • (2000) Mol Pharmacol , vol.57 , pp. 976-983
    • Ishizaki, T.1
  • 33
    • 77951705539 scopus 로고    scopus 로고
    • Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction
    • Gomez, E. W., Chen, Q. K., Gjorevski, N. and Nelson, C. M. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem 110, 44-51 (2010).
    • (2010) J Cell Biochem , vol.110 , pp. 44-51
    • Gomez, E.W.1    Chen, Q.K.2    Gjorevski, N.3    Nelson, C.M.4
  • 34
    • 33744956176 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner
    • Woods, A. and Beier, F. RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner. J Biol Chem 281, 13134-13140 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 13134-13140
    • Woods, A.1    Beier, F.2
  • 35
    • 0035065418 scopus 로고    scopus 로고
    • Effects of cytochalasin D and latrunculin B on mechanical properties of cells
    • Wakatsuki, T., Schwab, B., Thompson, N. C. and Elson, E. L. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci 114, 1025-1036 (2001).
    • (2001) J Cell Sci , vol.114 , pp. 1025-1036
    • Wakatsuki, T.1    Schwab, B.2    Thompson, N.C.3    Elson, E.L.4
  • 36
    • 57549105751 scopus 로고    scopus 로고
    • Substrate modulus directs neural stem cell behavior
    • Saha, K. et al. Substrate modulus directs neural stem cell behavior. Biophys J 95, 4426-4438 (2008).
    • (2008) Biophys J , vol.95 , pp. 4426-4438
    • Saha, K.1
  • 37
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. and Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6, 483-495 (2004).
    • (2004) Dev Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 38
    • 15544383394 scopus 로고    scopus 로고
    • Embryonic stem cells: Prospects for developmental biology and cell therapy
    • Wobus, A. M. and Boheler, K. R. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol Rev 85, 635-678 (2005).
    • (2005) Physiol Rev , vol.85 , pp. 635-678
    • Wobus, A.M.1    Boheler, K.R.2
  • 39
    • 64549140750 scopus 로고    scopus 로고
    • Human embryonic stem cell technologies and drug discovery
    • Jensen, J., Hyllner, J. and Bjorquist, P. Human embryonic stem cell technologies and drug discovery. J Cell Physiol 219, 513-519 (2009).
    • (2009) J Cell Physiol , vol.219 , pp. 513-519
    • Jensen, J.1    Hyllner, J.2    Bjorquist, P.3
  • 40
    • 77649285139 scopus 로고    scopus 로고
    • Stem cell paracrine actions and tissue regeneration
    • Baraniak, P. R. and McDevitt, T. C. Stem cell paracrine actions and tissue regeneration. Regen Med 5, 121-143 (2010).
    • (2010) Regen Med , vol.5 , pp. 121-143
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 41
    • 33947119175 scopus 로고    scopus 로고
    • The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    • Hardt, von der, S. et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr Biol 17, 475-487 (2007).
    • (2007) Curr Biol , vol.17 , pp. 475-487
    • Hardt Von Der, S.1
  • 42
    • 19944428596 scopus 로고    scopus 로고
    • Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    • Yeung, T. et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil. Cytoskeleton 60, 24-34 (2005).
    • (2005) Cell Motil. Cytoskeleton , vol.60 , pp. 24-34
    • Yeung, T.1
  • 43
    • 0016758708 scopus 로고
    • Cell shape and membrane changes in the eight-cell mouse embryo: Prerequisites for morphogenesis of the blastocyst
    • Ducibella, T. and Anderson, E. Cell shape and membrane changes in the eight-cell mouse embryo: prerequisites for morphogenesis of the blastocyst. Dev Biol 47, 45-58 (1975).
    • (1975) Dev Biol , vol.47 , pp. 45-58
    • Ducibella, T.1    Anderson, E.2
  • 44
    • 84867563568 scopus 로고    scopus 로고
    • Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation
    • Nair, R., Ngangan, A. V., Kemp, M. L. and McDevitt, T. C. Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation. PLoS ONE 7, e42580 (2012).
    • (2012) PLoS ONE , vol.7
    • Nair, R.1    Ngangan, A.V.2    Kemp, M.L.3    McDevitt, T.C.4
  • 45
    • 84895067766 scopus 로고    scopus 로고
    • Quantifying cell-generated mechanical forces within living embryonic tissues
    • doi:10.1038/nmeth.2761.
    • Campas, O. et al. Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods (2013). doi:10.1038/nmeth.2761.
    • (2013) Nat Methods
    • Campas, O.1
  • 46
    • 68149138464 scopus 로고    scopus 로고
    • Mechanical characterization of differentiated human embryonic stem cells
    • Ofek, G. et al. Mechanical characterization of differentiated human embryonic stem cells. J Biomech Eng 131, 061011 (2009).
    • (2009) J Biomech Eng , vol.131 , pp. 061011
    • Ofek, G.1
  • 47
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • Discher, D. E., Janmey, P. and Wang, Y.-L. Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139-1143 (2005).
    • (2005) Science , vol.310 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.-L.3
  • 48
    • 84883059455 scopus 로고    scopus 로고
    • Nuclear lamin-A scales with tissue stiffness and enhances matrixdirected differentiation
    • Swift, J. et al. Nuclear lamin-A scales with tissue stiffness and enhances matrixdirected differentiation. Science 341, 1240104 (2013).
    • (2013) Science , vol.341 , pp. 1240104
    • Swift, J.1
  • 50
    • 23844487086 scopus 로고    scopus 로고
    • Emergent patterns of growth controlled by multicellular form and mechanics
    • Nelson, C. M. et al. Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci USA 102, 11594-11599 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11594-11599
    • Nelson, C.M.1
  • 51
    • 76249131225 scopus 로고    scopus 로고
    • Cytoskeleton-based forecasting of stem cell lineage fates
    • Treiser, M. D. et al. Cytoskeleton-based forecasting of stem cell lineage fates. Proc Natl Acad Sci USA 107, 610-615 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 610-615
    • Treiser, M.D.1
  • 52
    • 84862215524 scopus 로고    scopus 로고
    • Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells
    • Gonza'lez-Cruz, R. D., Fonseca, V. C. and Darling, E. M. Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells. Proc Natl Acad Sci USA 109, E1523-9 (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Gonza'Lez-Cruz, R.D.1    Fonseca, V.C.2    Darling, E.M.3
  • 53
    • 84861697540 scopus 로고    scopus 로고
    • Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles
    • Baraniak, P. R. et al. Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles. J Mech Behav Biomed Mater 11, 63-71 (2012).
    • (2012) J Mech Behav Biomed Mater , vol.11 , pp. 63-71
    • Baraniak, P.R.1
  • 54
    • 79953267538 scopus 로고    scopus 로고
    • A bioinformatic assay for pluripotency in human cells
    • Muller, F.-J. et al. A bioinformatic assay for pluripotency in human cells. Nat Methods 8, 315-317 (2011).
    • (2011) Nat Methods , vol.8 , pp. 315-317
    • Muller, F.-J.1
  • 55
    • 77951228475 scopus 로고    scopus 로고
    • Mechanical control of tissue and organ development
    • Mammoto, T. and Ingber, D. E. Mechanical control of tissue and organ development. Development 137, 1407-1420 (2010).
    • (2010) Development , vol.137 , pp. 1407-1420
    • Mammoto, T.1    Ingber, D.E.2
  • 56
    • 0346220073 scopus 로고    scopus 로고
    • Defined conditions for neural commitment and differentiation
    • Ying, Q.-L. and Smith, A. G. Defined conditions for neural commitment and differentiation. Meth Enzymol 365, 327-341 (2003).
    • (2003) Meth Enzymol , vol.365 , pp. 327-341
    • Ying, Q.-L.1    Smith, A.G.2
  • 57
    • 49349089574 scopus 로고    scopus 로고
    • Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media
    • Purpura, K. A., Morin, J. and Zandstra, P. W. Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media. Exp Hematol 36, 1186-1198 (2008).
    • (2008) Exp Hematol , vol.36 , pp. 1186-1198
    • Purpura, K.A.1    Morin, J.2    Zandstra, P.W.3
  • 58
    • 34250206996 scopus 로고    scopus 로고
    • A ROCK inhibitor permits survival of dissociated human embryonic stem cells
    • Watanabe, K. et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnol 25, 681-686 (2007).
    • (2007) Nature Biotechnol , vol.25 , pp. 681-686
    • Watanabe, K.1
  • 59
    • 7044221770 scopus 로고    scopus 로고
    • Unconfined creep compression of chondrocytes
    • Leipzig, N. D. and Athanasiou, K. A. K. A. Unconfined creep compression of chondrocytes. J Biomech 38, 77-85 (2005).
    • (2005) J Biomech , vol.38 , pp. 77-85
    • Leipzig, N.D.1    Athanasiou, K.A.A.2
  • 60
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29, e45 (2001).
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 61
    • 11144325691 scopus 로고
    • Partial least-squares regression: A tutorial
    • Geladi, P. and Kowalski, B. R. Partial least-squares regression: a tutorial. Analytica Chimica Acta 185, 1-17 (1986).
    • (1986) Analytica Chimica Acta , vol.185 , pp. 1-17
    • Geladi, P.1    Kowalski, B.R.2
  • 62
    • 33846554088 scopus 로고    scopus 로고
    • ModelingHER2 effects on cell behavior from mass spectrometry phosphotyrosine data
    • Kumar, N., Wolf-Yadlin, A., White, F. M. and Lauffenburger, D. A. ModelingHER2 effects on cell behavior from mass spectrometry phosphotyrosine data. PLoS Comput Biol 3, e4 (2007).
    • (2007) PLoS Comput Biol , vol.3
    • Kumar, N.1    Wolf-Yadlin, A.2    White, F.M.3    Lauffenburger, D.A.4
  • 63
    • 84870021530 scopus 로고    scopus 로고
    • Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation
    • Park, K.-Y., Li, W. A. and Platt, M. O. Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation. Integr Biol 4, 1459-1469 (2012).
    • (2012) Integr Biol , vol.4 , pp. 1459-1469
    • Park, K.-Y.1    Li, W.A.2    Platt, M.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.