Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Ratia, Kiira ^a   Light, Samuel H ^b   Antanasijevic, Aleksandar ^a   Anderson, Wayne F ^b   Caffrey, Michael ^a   Lavie, Arnon ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; 3 DEHYDROSHIKIMATE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; SHIKIMATE DEHYDROGENASE; SHIKIMATE KINASE; SHIKIMIC ACID; SHIKIMIC ACID 3 PHOSPHATE; UNCLASSIFIED DRUG; HYDROLYASE;

AMINO ACID SYNTHESIS; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTEROIDES THETAIOTAOMICRON; BIOPHYSICS; CLOSTRIDIUM DIFFICILE; DEHYDRATION; DRUG PROTEIN BINDING; ENZYME KINETICS; FEASIBILITY STUDY; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; DRUG DEVELOPMENT; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMAN; METABOLISM; PEPTOCLOSTRIDIUM DIFFICILE;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; DRUG DISCOVERY; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; HYDRO-LYASES;

EID: 84896774981     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089356     Document Type: Article

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