Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability

Pathology

Volumn 45, Issue 7, 2013, Pages 645-650

  Je, Eun Mi ^a   Gwak, Min ^a   Oh, Hyerim ^a   Choi, Mi Ryoung ^a   Choi, Youn Jin ^a   Lee, Sug Hyung ^a   Yoo, Nam Jin ^a  

^a The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Axon guidance gene; Cancer; Expression; Frameshift mutation; Microsatellite instability; ROBO1; ROBO2

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; NERVE PROTEIN; ROBO2 PROTEIN, HUMAN; ROUNDABOUT RECEPTOR;

ARTICLE; COLORECTAL TUMOR; DNA SEQUENCE; FRAMESHIFT MUTATION; GENETIC DATABASE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROSATELLITE INSTABILITY; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH TUMOR;

COLORECTAL NEOPLASMS; DATABASES, GENETIC; FRAMESHIFT MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, IMMUNOLOGIC; SEQUENCE ANALYSIS, DNA; STOMACH NEOPLASMS;

EID: 84896750244     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0000000000000007     Document Type: Article

References (25)

1. Topczewska JM, Postovit LM, Margaryan N.V., et al Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 2006; 12: 925-32.
2. Mehlen P, Delloye-Bourgeois C, Chédotal A. Novel roles for Slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer 2011; 11: 188-97.
3. Stella MC, Trusolino L, Comoglio PM The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis. Mol Biol Cell 2009; 20: 642-57.
4. Tseng RC, Lee SH, Hsu H.S., et al SLIT2 attenuation during lung cancer progression deregulates beta-catenin and E-cadherin and associates with poor prognosis. Cancer Res 2010; 70: 543-51.
5. Prasad A, Paruchuri V, Preet A., Latif F, Ganju RK Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells. J Biol Chem 2008; 283: 26624-33.
6. Wang B, Xiao Y, Ding B.B., et al Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 2003; 4: 19-29.
7. Dickinson RE, Duncan WC The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system. Reproduction 2010; 139: 697-704.
8. Xian J, Clark KJ, Fordham R, Pannell R., Rabbitts TH, Rabbitts PH Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci USA 2001; 98: 15062-6.
9. Xian J, Aitchison A, Bobrow L., et al Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res 2004; 64: 6432-7.
10. Mitra S, Mazumder-Indra D, Mondal R.K., et al Inactivation of SLIT2-ROBO1/2 pathway in premalignant lesions of uterine cervix: clinical and prognostic significances. PLoS One 2012; 7: e38342.
11. Sundaresan V, Chung G, Heppell-Parton A, et al Homozygous deletions at 3p12 in breast and lung cancer. Oncogene 1998; 17: 1723-9.
12. Dallol A, Forgacs E, Martinez A., et al Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. Oncogene 2002; 21: 3020-8.
13. Ghosh S, Ghosh A, Maiti G.P., et al Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications. Hum Genet 2009; 125: 189-98.
14. Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012; 491: 399-405.
15. Ong CK, Subimerb C, Pairojkul C., et al Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet 2012; 44: 690-3.
16. Gröne J., Doebler O, Loddenkemper C., Hotz B, Buhr HJ, Bhargava S. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. Oncol Rep 2006; 15: 1437-43.
17. Imai K, Yamamoto H. Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 2008; 29: 673-80.
18. Cancer Genome Atlas NetworkComprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-7.
19. Wang K, Kan J, Yuen S.T., et al Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet 2011; 43: 1219-23.
20. Zang ZJ, Cutcutache I, Poon S.L., et al Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet 2012; 44: 570-4.
21. Wood LD, Parsons DW, Jones S, et al The genomic landscapes of human breast and colorectal cancers. Science 2007; 318: 1108-13.
22. Lee JW, Soung YH, Kim S.Y., et al PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005; 24: 1477-80.
23. Kim MS, Oh JE, Kim Y.R., et al Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. J Pathol 2010; 221: 139-46.
24. Kim MS, Hur SY, Yoo N.J., Lee SH Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of ovary and other human cancers. J Pathol 2010; 221: 147-52.
25. Kim YR, Oh JE, Kim M.S., et al Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 2010; 220: 446-51.