SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 558-566

  Nesi, Giulia ^a   Colabufo, Nicola Antonio ^b   Contino, Marialessandra ^b   Perrone, Maria Grazia ^b   Digiacomo, Maria ^a   Perrone, Roberto ^b   Lapucci, Annalina ^a   Macchia, Marco ^a   Rapposelli, Simona ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Arylmethyloxyphenyl compounds; Cancer; Neurodegenerative diseases; P gp ligands

Indexed keywords

1 [(2,3 DIMETHOXYBENZYL)OXY] 2 [2 (3,4,5 TRIMETHOXYPHENYL) ETHYL] BENZENE; 1 [(2,4 DICHLOROBENZYL)OXY] 2 (2 PHENYLETHYL)BENZENE; 1 [(3,4 DIMETHOXYBENZYL)OXY] 2 [2 (3,4 DIMETHOXYPHENYL) ETHYL] BENZENE; 1 [(3,4 DIMETHOXYBENZYL)OXY] 2 [2 (3,4,5 TRIMETHOXYPHENYL) ETHYL] BENZENE; 1 [(3,4 TRIMETHOXYBENZYL)OXY] 2 [2 (3,4,5 TRIMETHOXYPHENYL) ETHYL] BENZENE; 1 [(3,4,5 TRIMETHOXYBENZYL)OXY] 2 [2 (2,3 DIMETHOXYPHENYL) ETHYL] BENZENE; 1 [(3,4,5 TRIMETHOXYBENZYL)OXY] 2 [2 (3 METHOXYPHENYL) ETHYL] BENZENE; 1 [(3,5 DIMETHOXYBENZYL)OXY] 2 [2 (3,4,5 TRIMETHOXYPHENYL) ETHYL] BENZENE; 2 [(2 (2 (3 METHOXYPHENYL)ETHYL)PHENOXY)METHYL]PYRIMIDINE; 2 [(2 (2 (3 METHOXYPHENYL)ETHYL)PHENOXY)METHYL]THIOPHENE; 2 [(E) 2 (3,4,5 TRIMETHOXYPHENYL)VINYL]PHENOL; 2 [(E/Z) 2 (2,3 DIMETHOXYPHENYL)VINYL]PHENOL; 2 [(E/Z) 2 (3,4 DIMETHOXYPHENYL)VINYL]PHENOL; 2 [(Z) 2 (3,4,5 TRIMETHOXYPHENYL)VINYL]PHENOL; 2 [2 (2,3 DIMETHOXYPHENYL)ETHYL]PHENOL; 2 [2 (3 METHOXYPHENYL)ETHYL] N (PYRIDIN 4 YLMETHYL)ANILINE; 2 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL]PHENOL; 2,3 DIMETHOXYBENZYL(BROMO)TRIPHENYLPHOSPHORANE; 3 METHOXY N [2 (2 (3 METHOXYPHENYL)ETHYL)PHENYL] BENZAMIDE; 3,4 DIMETHOXYBENZYL(CHLORO)TRIPHENYLPHOSPHORANE; 3,4,5 TRIMETHOXYBENZYL(CHLORO)TRIPHENYLPHOSPHORANE; 5 [(2 (2 (3 METHOXYPHENYL)ETHYL)PHENOXY)METHYL]1,3BENZODIOXOLE; ARYLMETHYLOXYPHENYL DERIVATIVE; BENZENE DERIVATIVE; LIGAND; N [2(2 (3 METHOXYPHENYL)ETHYL)PHENYL]NICOTINAMIDE; PYRIMIDINE; THIOPHENE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; BIOASSAY; CELL STRAIN CACO 2; CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; ELECTRON; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; P-GLYCOPROTEIN; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896742967     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.051     Document Type: Article

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