Timing of GTP binding and hydrolysis by translation termination factor RF3

Nucleic Acids Research

Volumn 42, Issue 3, 2014, Pages 1812-1820

  Peske, Frank ^a   Kuhlenkoetter, Stephan ^a   Rodnina, Marina V ^a   Wintermeyer, Wolfgang ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; PEPTIDE TRANSFER RIBONUCLEIC ACID; TRANSFER RNA; TRANSLATION TERMINATION FACTOR; TRANSLATION TERMINATION FACTOR RF3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEACYLATION; ENZYME REGULATION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN HYDROLYSIS; PROTEIN SECRETION; PROTEIN STABILITY; RIBOSOME;

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; KINETICS; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PEPTIDE TERMINATION FACTORS; RIBOSOMES;

EID: 84896739794     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt1095     Document Type: Article

References (34)

1. Ramakrishnan, V. (2002) Ribosome structure and the mechanism of translation. Cell, 108, 557-572.
2. Youngman, E.M., McDonald, M.E. and Green, R. (2008) Peptide release on the ribosome: mechanism and implications for translational control. Annu. Rev. Microbiol., 62, 353-373.
3. He, S.L. and Green, R. (2010) Visualization of codon-dependent conformational rearrangements during translation termination. Nat. Struct. Mol. Biol., 17, 465-470.
4. Frolova, L.Y., Tsivkovskii, R.Y., Sivolobova, G.F., Oparina, N.Y., Serpinsky, O.I., Blinov, V.M., Tatkov, S.I. and Kisselev, L.L. (1999) Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis. RNA, 5, 1014-1020.
5. Mora, L., Heurgue-Hamard, V., Champ, S., Ehrenberg, M., Kisselev, L.L. and Buckingham, R.H. (2003) The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2. Mol. Microbiol., 47, 267-275.
6. Seit-Nebi, A., Frolova, L., Justesen, J. and Kisselev, L. (2001) Class- 1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition. Nucleic Acids Res., 29, 3982-3987.
7. Shaw, J.J. and Green, R. (2007) Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol. Cell, 28, 458-467.
8. Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997) Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner. EMBO J., 16, 4126-4133.
9. Zaher, H.S. and Green, R. (2009) Quality control by the ribosome following peptide bond formation. Nature, 457, 161-166.
10. Zaher, H.S. and Green, R. (2011) A primary role for release factor 3 in quality control during translation elongation in Escherichia coli. Cell, 147, 396-408.
11. Jin, H., Kelley, A.C. and Ramakrishnan, V. (2011) Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3. Proc. Natl Acad. Sci. USA, 108, 15798-15803.
12. Zhou, J., Lancaster, L., Trakhanov, S. and Noller, H.F. (2012) Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. RNA, 18, 230-240.
13. Jin, H., Kelley, A.C., Loakes, D. and Ramakrishnan, V. (2010) Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release. Proc. Natl Acad. Sci. USA, 107, 8593-8598.
14. Laurberg, M., Asahara, H., Korostelev, A., Zhu, J., Trakhanov, S. and Noller, H.F. (2008) Structural basis for translation termination on the 70S ribosome. Nature, 454, 852-857.
15. Korostelev, A., Asahara, H., Lancaster, L., Laurberg, M., Hirschi, A., Zhu, J., Trakhanov, S., Scott, W.G. and Noller, H.F. (2008) Crystal structure of a translation termination complex formed with release factor RF2. Proc. Natl Acad. Sci. USA, 105, 19684-19689.
16. Weixlbaumer, A., Jin, H., Neubauer, C., Voorhees, R.M., Petry, S., Kelley, A.C. and Ramakrishnan, V. (2008) Insights into translational termination from the structure of RF2 bound to the ribosome. Science, 322, 953-956.
17. Zavialov, A.V., Buckingham, R.H. and Ehrenberg, M. (2001) A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3. Cell, 107, 115-124.
18. Zavialov, A.V., Mora, L., Buckingham, R.H. and Ehrenberg, M. (2002) Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3. Mol. Cell, 10, 789-798.
19. Zavialov, A.V. and Ehrenberg, M. (2003) Peptidyl-tRNA regulates the GTPase activity of translation factors. Cell, 114, 113-122.
20. Wilden, B., Savelsbergh, A., Rodnina, M.V. and Wintermeyer, W. (2006) Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome. Proc. Natl Acad. Sci. USA, 103, 13670-13675.
21. Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Cheng, Z., Liu, Y., Zavialov, A., Gursky, R. et al. (2007) RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell, 129, 929-941.
22. Rodnina, M.V. and Wintermeyer, W. (1995) GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs. Proc. Natl Acad. Sci. USA, 92, 1945-1949.
23. Milon, P., Konevega, A.L., Peske, F., Fabbretti, A., Gualerzi, C.O. and Rodnina, M.V. (2007) Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria. Methods Enzymol., 430, 1-30.
24. Kuhlenkoetter, S., Wintermeyer, W. and Rodnina, M.V. (2011) Different substrate-dependent transition states in the active site of the ribosome. Nature, 476, 351-354.
25. Pisareva, V.P., Pisarev, A.V., Hellen, C.U., Rodnina, M.V. and Pestova, T.V. (2006) Kinetic analysis of interaction of eukaryotic release factor 3 with guanine nucleotides. J. Biol. Chem., 281, 40224-40235.
26. Katunin, V.I., Savelsbergh, A., Rodnina, M.V. and Wintermeyer, W. (2002) Coupling of GTP hydrolysis by elongation factor G to translocation and factor recycling on the ribosome. Biochemistry, 41, 12806-12812.
27. Rodnina, M.V., Pape, T., Fricke, R., Kuhn, L. and Wintermeyer, W. (1996) Initial binding of the elongation factor Tu.GTP.aminoacyltRNA complex preceding codon recognition on the ribosome. J. Biol. Chem., 271, 646-652.
28. Bennett, B.D., Kimball, E.H., Gao, M., Osterhout, R., Van Dien, S.J. and Rabinowitz, J.D. (2009) Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat. Chem. Biol., 5, 593-599.
29. Bourne, H.R., Sanders, D.A. and McCormick, F. (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature, 349, 117-127.
30. Pape, T., Wintermeyer, W. and Rodnina, M. (1999) Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome. EMBO J., 18, 3800-3807.
31. Paleskava, A., Konevega, A.L. and Rodnina, M.V. (2010) Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB. J. Biol. Chem., 285, 3014-3020.
32. Chen, C., Stevens, B., Kaur, J., Cabral, D., Liu, H., Wang, Y., Zhang, H., Rosenblum, G., Smilansky, Z., Goldman, Y.E. et al. (2011) Single-molecule fluorescence measurements of ribosomal translocation dynamics. Mol. Cell, 42, 367-377.
33. Walker, S.E., Shoji, S., Pan, D., Cooperman, B.S. and Fredrick, K. (2008) Role of hybrid tRNA-binding states in ribosomal translocation. Proc. Natl Acad. Sci. USA, 105, 9192-9197.
34. Rodnina, M.V., Savelsbergh, A., Katunin, V.I. and Wintermeyer, W. (1997) Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome. Nature, 385, 37-41.