Age impacts on the independent relationships of leptin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: A cross-sectional study

Rheumatology International

Volumn 34, Issue 3, 2014, Pages 329-339

  Dessein, Patrick H ^a   Norton, Gavin R ^a   Woodiwiss, Angela J ^a   Tsang, Linda ^b   Solomon, Ahmed ^c  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b MILPARK HOSPITAL   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Endothelial activation; Leptin and cardiovascular risk; Rheumatoid arthritis

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AFRICAN AMERICAN; AGE DISTRIBUTION; ARTICLE; ATHEROGENESIS; BODY MASS; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE MARKER; EUROPEAN AMERICAN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SEX DIFFERENCE; WAIST CIRCUMFERENCE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGE FACTORS; AGED; AGING; ARTHRITIS, RHEUMATOID; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CHEMOKINE CCL2; CHOLESTEROL, HDL; COMORBIDITY; CROSS-SECTIONAL STUDIES; E-SELECTIN; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HEART DISEASES; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEPTIN; MALE; METABOLIC DISEASES; MIDDLE AGED; RISK FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84896736682     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-013-2933-7     Document Type: Article

References (51)

1. Koh KK, Park SM, Quon MJ (2008) Leptin and cardiovascular disease: response to therapeutic interventions. Circulation 117:3238-3249
2. Ren JA (2004) Leptin and hyperleptinemia - from friend to foe for cardiovascular function. J Endocrinol 181:1-10
3. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A (2002) Leptin-replacement therapy for lipodystrophy. N Engl J Med 346:570-578
4. Abel ED, Sweeney G (2012) Modulation of the cardiovascular system by leptin. Biochimie 94:2097-2103
5. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G (2002) Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 16:1163-1176
6. Schautz B, Later W, Heller M, Peters A, Muller MJ, Bosy-Westphal A (2012) Impact of age on leptin and adiponectin independent of adiposity. Br J Nutr 108:363-370
7. Ren J, Dong F, Cai G-J, Zhaso P, Nunn JM, Wold LE, Pei J (2010) Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling. PLoS ONE 5:e10085
8. Carter S, Caron A, Richard D, Picard F (2013) Role of leptin resistance in the development of obesity in older patients. Clin Interv Aging 8:829-844
9. Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, Garvey T (1997) The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 82:1293-1300
10. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3425-3427
11. Ruhl CE, Everhart JE (2001) Leptin concentrations in the United States: relations with demographic and anthropometric measures1'2'3. Am J Clin Nutr 74:295-301
12. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, Tylavsky FA, Harris TB, and for the Health, Aging, and Body Composition Study (2004) Serum leptin concentrations and body adipose measures in older black and white adults1'2'3. Am J Clin Nutr 80:576-583
13. Smith J, Al-Amri M, Sniderman A, Cianflone K (2006) Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metabol 3:18
14. Krysiak R, Handzlik-Orlik G, Okopien B (2012) The role of adipokines in connective tissue diseases. Eur J Nutr 51:513-528
15. Tong KM, Shieh DC, Chen CP, Tzeng CY, Wang SP, Huang KC, Chiu AC, Fong YC, Tang CH (2008) Leptin induces IL-8 expression via leptin receptor IRS-1, P13 K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts. Cell Signal 20:1478-1488
16. Lee SW, Park CM, Park YB, Lee SK (2007) Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol Int 27:537-540
17. Targonski-Stepniak B, Dryglewska M, Majdan M (2010) Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int 30:731-737
18. Popa C, Netea MG, de Graaf J, van den Hoogen FH, Radstake TR, Toenhake-Dijkstra H, van Riel PL, van der Meer JW, Stalenhoef AF, Barrera P (2009) Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis. J Rheumatol 36:724-730
19. Kopec-Medrek M, Kotulska A, Widuchowska M, Adamczak M, Wiecek A, Kucharz EJ (2012) Plasma leptin and neuropeptide Y concentrations in patients with rheumatoid arthritis treated with infliximab, a TNF-α antagonist. Rheumatol Int 32:3383-3389
20. Dessein PH, Norton GR, Badenhorst, Woodiwiss AJ, Solomon A (2013) Rheumatoid arthritis impacts on the independent relationships between circulating adiponectin concentrations and cardiovascular metabolic risk. Mediators Inflamm Article ID 461849
21. Gabriel SE, Crowson CS (2012) Risk factors for cardiovascular disease in rheumatoid arthritis. Curr Opin Rheumatol 24:171-176
22. Dessein PH, Semb AG (2013) Could cardiovascular disease risk stratification and management in rheumatoid arthritis be enhanced? Ann Rheum Dis 72:1743-1746
23. Rho YH, Chung CP, Solus JF, Raggi P, Oeser A, Gebretsadik T, Shintani A, Stein CM (2010) Adipocytokines, insulin resistance and coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum 62:1259-1264
24. Scotece M, Conde J, Gomez R, Lopez V, Pino J, Gonzalez A, Lago F, Gomez-Reino JJ, Gualillo O (2012) Role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseases. Mediator Inflamm Article ID 125458
25. Otero M, Lago R, Gomez R, Diequez C, Lago F, Gomez-Reino J, Gualillo O (2006) Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology 45:944-950
26. Gonzalez-Gay MA, Gonzalez-Juanatey C, Rodriguez-Rodriguez L, Miranda-Filloy JA, Martin J, Llorca J (2011) Lack of association between adipokines and ghrelin and carotid intima-media thickness in patients with severe rheumatoid arthritis. Clin Exp Rheumatol 29:358-359
27. Hahn BH, Lourencco EV, McMahon M, Skaggs B, Le E, Anderson M, Likuni N, Lai CK, La Cava A (2010) Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin. Lupus 19:913-917
28. Dessein PH, Woodiwiss AJ, Norton GR, Tsang L, Solomon A (2013) Independent associations of total and high molecular weight adiponectin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 15:R128
29. Dessein PH, Joffe BI, Singh S (2005) Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther 7:R634-R643
30. Sodergren A, Karp K, Boman K, Eriksson C, Lundstrom E, Smedby T, Soderlund L, Rantapaa-Dahlqvist S, Wallberg-Jonsson S (2010) Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness. Arthritis Res Ther 12:R158
31. Dessein PH, Joffe BI (2006) Suppression of interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis. Clin Exp Rheumatol 24:161-167
32. Dessein PH, Norton GR, Woodiwiss AJ, Solomon A (2013) Independent relationship between circulating resistin concentrations and endothelial activation in rheumatoid arthritis. Ann Rheum Dis 72:1586-1588
33. Arnett FC, Edworthy SM, Bloch DA, Mcshane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324
34. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 69:1580-1588
35. Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44-48
36. Gulfe A, Aletaha D, Saxne T, Geborek P (2009) Disease activity level, remission and response in established rheumatoid arthritis: performance of various criteria sets in an observational cohort, treated with anti-TNF agents. BMC Musculoskelet Discord 10:41
37. Myasoedova E, Crowson CS, Turesson C, Gabriel SE, Matteson EL (2011) Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995-2007 versus 1985-1994: a population-based study. J Rheumatol 38:983-989
38. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137-147
39. Solomon A, Norton GR, Woodiwiss AJ, Dessein PH (2012) Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 14:R67
40. Dessein PH, Christian BF, Solomon A (2009) Which are the determinants of dyslipidemia in rheumatoid arthritis and does socioeconomic status matter in this regard? J Rheumatol 36:1357-1369
41. Grundy SM, Cleeman JI, Daniels SR, Konato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heat, Lung, and Blood Institute Scientific Statement. Circulation 112:2735-2752
42. Gonzalez-Gay MA, Garcia-Unzueta MT, Berja A, Gonzalez-Juanatey C, Miranda-Filloy JA, Vazquez-Rodriguez TR, de Matias JM, Martin J, Dessein PH, Llorca J (2009) Anti-TNF-alpha therapy does not modulate leptin in patients with severe rheumatoid arthritis. Clin Exp Rheumatol 27:222-228
43. Curtis JR, van der Helm-van Mil AH, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G, Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick NA, Hamburger M, Fleischmann R, Keystone E, Weinblatt ME (2012) Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity. Arthritis Care Res 64:1794-1803
44. Windham BG, Griswold ME, Farasat SM, Ling SM, Carlson O, Egan JM, Ferrucci L, Najjar SS (2010) Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens 23:501
45. Porreca E, Di Febbo C, Fusco L, Moretta V, Di Nisio M, Cuccurullo F (2004) Soluble thrombomodulin and vascular adhesion molecule-1 are associated to leptin plasma levels in obese women. Atherosclerosis 172:175-180
46. Escalante A, Haas RW, del Rincon I (2005) Paradoxical effect of body mass index on survival in rheumatoid arthritis. Arch Intern Med 165:1624-1629
47. Maradit Kremers H, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE (2004) Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis. Arthritis Rheum 50:3450-3457
48. Crowson CS, Liang KP, Therneau TM, Maradit Kremers H, Gabriel SE (2010) Could accelerated aging explain the excess mortality in seropositive rheumatoid arthritis patients? Arthritis Rheum 62:378-382
49. Bender R, Jockel K-H, Trautner C, Spraul M, Berger M (1999) Effect of age on excess mortality in obesity. J Am Med Ass 281:1498-1504
50. Beltowski J (2006) Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 24:789-801
51. Gonzalez-Gay MA, Garcia-Unzueta MT, Gonzalez-Juanatey C, Miranda-Filloy JA, Vasquez-Rodriguez TR, De Matias J, Dessein PH, Llorca J (2008) Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis. Clin Exp Rheumatol 26:311-316