A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells

Archives of Toxicology

Volumn 88, Issue 3, 2014, Pages 823-836

  Schumacher, Fabian ^a   Florian, Simone ^a   Schnapper, Anke ^a,b   Monien, Bernhard H ^a   Mewis, Inga ^c   Schreiner, Monika ^c   Seidel, Albrecht ^d   Engst, Wolfram ^a   Glatt, Hansruedi ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c LEIBNIZ INSTITUTE OF VEGETABLE AND ORNAMENTAL CROPS   (Germany)

^d Prof Dr Gernot Grimmer Foundation   (Germany)

Author keywords

DNA adducts; Glucosinolates; Immunohistochemistry; Sulphotransferase; UPLC MS MS

Indexed keywords

1 METHOXY 3 INDOLYLMETHYL ALCOHOL; 1 METHOXY 3 INDOLYLMETHYL GLUCOSINOLATE; ALCOHOL DERIVATIVE; GLUCOSINOLATE; GLYCOGEN; PROTEIN P21; PROTEIN P53; THIOGLUCOSIDASE; UNCLASSIFIED DRUG; 1-METHOXY-3-INDOLYLMETHYLGLUCOSINOLATE; 2'-DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; DNA ADDUCT; INDOLE DERIVATIVE; N-METHOXYINDOLE-3-CARBINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRASSICALES; CECUM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA ADDUCT; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; LARGE INTESTINE; LIVER; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; ANIMAL; BRASSICACEAE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; INBRED MOUSE STRAIN; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PROCEDURES;

BRASSICALES; MUS;

ADMINISTRATION, ORAL; ANIMALS; BRASSICACEAE; CECUM; DEOXYADENOSINES; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSINOLATES; INDOLES; INTESTINE, LARGE; LIVER; MALE; MICE; MICE, INBRED STRAINS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896735727     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1149-7     Document Type: Article

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