Saponin 1 induces apoptosis and suppresses NF-κB-mediated survival signaling in glioblastoma multiforme (GBM)

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Li, Juan ^a   Tang, Haifeng ^b   Zhang, Yun ^a   Tang, Chi ^a   Li, Bo ^a   Wang, Yuangang ^a   Gao, Zhenhui ^a   Luo, Peng ^a   Yin, Anan ^a   Wang, Xiaoyang ^b   Cheng, Guang ^a   Fei, Zhou ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; SAPONIN 1; SURVIVIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CANCER INHIBITION; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; BRAIN NEOPLASMS; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; HL 60 CELL LINE; INTRACELLULAR SPACE; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN NEOPLASMS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HEP G2 CELLS; HL-60 CELLS; HUMANS; INTRACELLULAR SPACE; MICE; NF-KAPPA B; PLANT EXTRACTS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; SAPONINS; SIGNAL TRANSDUCTION; TUMOR BURDEN; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84896730492     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081258     Document Type: Article

References (29)

1. Preusser M, de Ribaupierre S, Wöhrer A, Erridge SC et al. (2011) Current concepts and management of glioblastoma. Ann Neurol 70: 9-21. doi:10.1002/ana.22542. PubMed: 21786296.
2. Stupp R, Weller M (2010) 2010: neuro-oncology is moving! Curr Opin Neurol 23: 553-555. doi:10.1097/WCO.0b013e3283407eed. PubMed: 21051962.
3. Darefsky AS, King JT Jr, Dubrow R (2012) Adult glioblastoma multiforme survival in the temozolomide era: A population-based analysis of surveillance, epidemiology, and end results registries. Cancer 118: 2163-2172. doi:10.1002/cncr.26494. PubMed: 21882183.
4. Hegi ME, Janzer RC, Lambiv WL, Gorlia T, Kouwenhoven MC et al. (2012) Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC-26981/NCIC-CE.3 trial. Acta Neuropathol 123: 841-852. doi:10.1007/s00401-011-0938-4. PubMed: 22249618.
5. Kisková T, Ekmekcioglu C, Garajová M, Orendáš P et al. (2012) A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur J Cancer Prev 21: 163-170. doi:10.1097/CEJ. 0b013e32834c9c0f. PubMed: 22044852.
6. Lee MH, Choi BY, Kundu JK, Shin YK, Na HK et al. (2009) Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res 69: 7449-7458. doi:10.1158/0008-5472.CAN-09-1266. PubMed: 19738051.
7. Filippi-Chiela EC, Villodre ES, Zamin LL, Lenz G (2011) Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLOS ONE 6: e20849. doi:10.1371/journal. pone.0020849. PubMed: 21695150.
8. Xiong J, Cheng G, Tang H, Zhen HN, Zhang X (2009) Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway. Environ Toxicol Pharmacol 27: 264-270. doi:10.1016/j.etap.2008.11.008. PubMed: 21783950.
9. Lin H, Zhang X, Cheng G, Tang HF, Zhang W et al. (2008) Apoptosis induced by ardipusilloside III through BAD dephosphorylation and cleavage in human glioblastoma U251MG cells. Apoptosis 13: 247-257. doi:10.1007/s10495-007-0170-9. PubMed: 18181022.
10. Jiang H, Shang X, Wu H, Gautam SC, Al-Holou S et al. (2009) Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol 8: 25-33. PubMed: 19827268.
11. Wang XY, Chen XL, Tang HF, Gao H, Tian XR et al. (2011) Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis. Planta Med 77: 1550-1554. doi:10.1055/s-0030-1270821. PubMed: 21347998.
12. Curčić MG, Stanković MS, Mrkalić EM, Matović ZD, Banković DD et al. (2012) Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex. Int J Mol Sci 13: 2521-2534. doi:10.3390/ijms13022521. PubMed: 22408469.
13. Williams DB, Carter CB (2009) Transmission electron microscopy: a textbook for materials science. Springer, Germany.
14. Diwu YC, Tian JZ, Shi J (2011) Effects of Chinese herbal medicine Yinsiwei compound on spatial learning and memory ability and the ultrastructure of hippocampal neurons in a rat model of sporadic Alzheimer disease. Zhong Xi Yi Jie He Xue Bao 9: 209-215.
15. Ditsch N, Toth B, Mayr D, Lenhard M, Gallwas J et al. (2012) The association between vitamin D receptor expression and prolonged overall survival in breast cancer. J Histochem Cytochem 60: 121-129. doi:10.1369/ 0022155411429155. PubMed: 22108646.
16. Motomura K, Natsume A, Kishida Y, Higashi H, Kondo Y et al. (2011) Benefits of interferon-beta and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: A multicenter study. Cancer 117: 1721-1730. doi:10.1002/cncr.25637. PubMed: 21472719.
17. Nogueira L, Ruiz-Ontañon P, Vazquez-Barquero A, Moris F, Fernandez-Luna JL (2011) The NFkappaB pathway: a therapeutic target in glioblastoma. Oncotarget 2: 646-653. PubMed: 21896960.
18. Smith D, Shimamura T, Barbera S, Bejcek BE (2008) NF-kappaB controls growth of glioblastomas/astrocytomas. Mol Cell Biochem 307: 141-147. PubMed: 17828582.
19. Zhao X, Laver T, Hong SW, Twitty GB Jr, Devos A et al. (2011) An NF-kappaB p65-cIAP2 link is necessary for mediating resistance to TNF-alpha induced cell death in gliomas. J Neurooncol 102: 367-381. doi:10.1007/s11060- 010-0346-y. PubMed: 21279667.
20. Guo K, Kang NX, Li Y, Sun L, Gan L et al. (2009) Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis. BMC Cancer 9: 100. doi:10.1186/1471-2407-9-100. PubMed: 19331697.
21. Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J et al. (2010) Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol 21: 864-870. doi:10.1093/annonc/mdp390. PubMed: 19850643.
22. Pavlyukov MS, Antipova NV, Balashova MV, Vinogradova TV, Kopantzev EP et al. (2011) Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem 286: 23296-23307. doi:10.1074/jbc.M111.237586. PubMed: 21536684.
23. Zanotto-Filho A, Braganhol E, Schröder R, de Souza LH, Dalmolin RJ et al. (2011) NFkappaB inhibitors induce cell death in glioblastomas. Biochem Pharmacol 81: 412-424. doi:10.1016/j.bcp.2010.10.014. PubMed: 21040711.
24. George J, Banik NL, Ray SK (2010) Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo. Neuro Oncol 12: 1088-1101. doi:10.1093/neuonc/noq079. PubMed: 20679253.
25. Kogiku M, Ohsawa I, Matsumoto K, Sugisaki Y, Takahashi H et al. (2008) Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J Clin Neurosci 15: 1198-1203. doi:10.1016/j.jocn.2007.11.012. PubMed: 18835716.
26. Angileri FF, Aguennouz M, Conti A, La Torre D, Cardali S et al. (2008) Nuclear factor-kappaB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas. Cancer 112: 2258-2266. doi:10.1002/cncr.23407. PubMed: 18327814.
27. Zhen HN, Zhang X, Hu PZ, Yang TT, Fei Z et al. (2005) Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas. Cancer 105: 2775-2783. PubMed: 16284993.
28. Mita AC, Mita MM, Nawrocki ST, Giles FJ (2008) Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer. Therapeutics - Clin Cancer Res 14: 5000-5005. doi:10.1158/1078-0432.CCR-08-0746.
29. Chen XQ, Yang S, Li ZY, Lu HS, Kang MQ et al. (2012) Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells. Mol Med Report 5: 917-922.