Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women

European Journal of Nutrition

Volumn 53, Issue 2, 2014, Pages 441-448

  Toxqui, Laura ^a   Pérez Granados, Ana M ^a   Blanco Rojo, Ruth ^a   Wright, Ione ^a   De La Piedra, Concepción ^b   Vaquero, M Pilar ^a  

^a INSTITUTE OF FOOD SCIENCE   (Spain)

^b 28400 Madrid   (Spain)

Author keywords

25 hydroxyvitamin D; Bone turnover markers; Fortified food; Iron deficiency; Menstruating women; Vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; FERRITIN; IRON; PARATHYROID HORMONE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; TELOPEPTIDE; TRANSFERRIN; VITAMIN D;

ADULT; ARTICLE; BODY WEIGHT; BONE METABOLISM; BONE REMODELING; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IRON BALANCE; IRON DEFICIENCY; MILK; OSTEOLYSIS; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; WOMEN'S HEALTH; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; BONE REMODELING; BONE RESORPTION; COLLAGEN TYPE I; DIET; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; FOOD, FORTIFIED; HUMANS; IRON; MILK; NUTRITIONAL STATUS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PEPTIDES; PROCOLLAGEN; SPAIN; TRANSFERRIN; VITAMIN D; YOUNG ADULT;

EID: 84896729855     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0544-4     Document Type: Article

References (35)

1. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S-1086S
2. Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477-501
3. Laird E, Ward M, McSorley E, Strain JJ, Wallace J (2010) Vitamin D and bone health: potential mechanisms. Nutrients 2:693-724. doi: 10.3390/nu2070693
4. Holick MF (2010) Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 39:381-400. doi: 10.1016/j.ecl.2010.02.016
5. McGillivray G, Skull SA, Davie G, Kofoed SE, Frydenberg A, Rice J, Cooke R, Carapetis JR (2007) High prevalence of asymptomatic vitamin D and iron deficiency in East African immigrant children and adolescents living in a temperate climate. Arch Dis Child 92:1088-1093
6. Sim JJ, Lac PT, Liu IL, Meguerditchian SO, Kumar VA, Kujubu DA, Rasgon SA (2010) Vitamin D deficiency and anemia: a cross-sectional study. Ann Hematol 89:447-452. doi: 10.1007/s00277-009-0850-3
7. Toxqui L, Pérez-Granados AM, Blanco-Rojo R, Wright I, González-Vizcayno C, Vaquero MP (2013) Intake of an iron or iron an vitamin D-fortified skimmed milk and iron metabolism in women. Ann Nutr Metab (in press)
8. Blanco-Rojo R, Perez-Granados AM, Toxqui L, Zazo P, de la Piedra C, Vaquero MP (2013) Relationship between vitamin D deficiency, bone remodelling and iron status in iron-deficient young women consuming an iron-fortified food. Eur J Nutr 52:695-703. doi: 10.1007/s00394-012-0375-8
9. Tuderman L, Myllyla R, Kivirikko KI (1977) Mechanism of the prolyl hydroxylase reaction.1. Role of co-substrates. Eur J Biochem 80:341-348
10. Diaz-Castro J, Lopez-Frias MR, Campos MS, Lopez-Frias M, Alferez MJ, Nestares T, Ojeda ML, Lopez-Aliaga I (2012) Severe nutritional iron-deficiency anaemia has a negative effect on some bone turnover biomarkers in rats. Eur J Nutr 51:241-247. doi: 10.1007/s00394-011-0212-5
11. Katsumata S, Tsuboi R, Uehara M, Suzuki K (2006) Dietary iron deficiency decreases serum osteocalcin concentration and bone mineral density in rats. Biosci Biotechnol Biochem 70:2547-2550
12. Katsumata S, Katsumata-Tsuboi R, Uehara M, Suzuki K (2009) Severe iron deficiency decreases both bone formation and bone resorption in rats. J Nutr 139:238-243
13. Harris MM, Houtkooper LB, Stanford VA, Parkhill C, Weber JL, Flint-Wagner H, Weiss L, Going SB, Lohman TG (2003) Dietary iron is associated with bone mineral density in healthy postmenopausal women. J Nutr 133:3598-3602
14. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266-281
15. Gonzalez-Molero I, Morcillo S, Valdes S, Perez-Valero V, Botas P, Delgado E, Hernandez D, Olveira G, Rojo G, Gutierrez-Repiso C, Rubio-Martin E, Menendez E, Soriguer F (2011) Vitamin D deficiency in Spain: a population-based cohort study. Eur J Clin Nutr 65:321-328
16. Vaquero MP, Sanchez-Muniz FJ, Carbajal A, Garcia-Linares MC, Garcia-Fernandez MC, Garcia-Arias MT (2004) Mineral and vitamin status in elderly persons from Northwest Spain consuming an Atlantic variant of the Mediterranean diet. Ann Nutr Metab 48:125-133
17. Mata-Granados JM, Luque de Castro MD, Quesada Gomez JM (2008) Inappropriate serum levels of retinol, alpha-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: simultaneous assessment by HPLC. Clin Biochem 41:676-680. doi: 10.1016/j.clinbiochem.2008.02. 003
18. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B (2009) Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr 12:444-454. doi: 10.1017/S1368980008002401
19. Lips P (2010) Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 121:297-300. doi: 10.1016/j.jsbmb.2010.02.021
20. Moreiras O, Carbajal A, Cabrera L, Cuadrado C (2009) Ingestas recomendadas de energía y nutrientes para la población española. In: Tablas de composición de alimentos. Pirámide, Grupo Anaya, SA, Madrid, pp 227-230
21. Institute of Medicine (2001) Iron. In: Institute of Medicine and Food and Nutrition Board (ed) Dietary Reference Intakes for Vitamin A, Vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academic Press, Washington, DC, pp 290-393
22. Ross AC, Taylor CL, Yaktine AL, Del Valle HB (2011) Dietary Reference Intakes for Calcium Vitamin D. The National Academic Press, Washington, D.C
23. Ferrar L, van der Hee RM, Berry M, Watson C, Miret S, Wilkinson J, Bradburn M, Eastell R (2011) Effects of calcium-fortified ice cream on markers of bone health. Osteoporos Int 22:2721-2731. doi: 10.1007/s00198-010-1513-x
24. D'Amelio P, Cristofaro MA, Tamone C, Morra E, Di Bella S, Isaia G, Grimaldi A, Gennero L, Gariboldi A, Ponzetto A, Pescarmona GP, Isaia GC (2008) Role of iron metabolism and oxidative damage in postmenopausal bone loss. Bone 43:1010-1015. doi: 10.1016/j.bone.2008.08.107
25. Medeiros DM, Stoecker B, Plattner A, Jennings D, Haub M (2004) Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight. J Nutr 134:3061-3067
26. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53-58. doi: 10.1210/jc.2010-2704
27. van Schoor NM, Lips P (2011) Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab 25:671-680. doi: 10.1016/j.beem.2011.06.007S1521-690X(11) 00071-6
28. Rodriguez Sangrador M, Beltran de Miguel B, Cuadrado Vives C, Moreiras Tuny O (2010) Influence of sun exposure and diet to the nutritional status of vitamin D in adolescent Spanish women: the five countries study (OPTIFORD Project). Nutr Hosp 25:755-762
29. Groba MV, Miravalle A, Gonzalez-Rodriguez E, García-Santana S, Gonzalez-Padilla E, Saavedra P, Soria A, Sosa M (2010) Factors related to vitamin D deficiency in medical students in Gran Canaria. Revista de osteoporosis y metabolismo mineral 2:11-18
30. Federación Española de Sociedades de Nutrición Alimentación y Dietética (FESNAD) (2010) Ingestas Dietéticas de Referencia (IDR) para la población española. EUNSA, Navarra
31. Vinas BR, Barba LR, Ngo J, Gurinovic M, Novakovic R, Cavelaars A, de Groot LC, van't Veer P, Matthys C, de Majem LS (2011) Projected prevalence of inadequate nutrient intakes in Europe. Ann Nutr Metab 59:84-95. doi: 10.1159/000332762
32. Vaquero MP, Navarro MP (2013) Minerales. Libro blanco de la nutrición en España. Fundación Española de Nutrición, Madrid, pp 157-163
33. Kemi VE, Kärkkäinen MU, Lamberg-Allardt CJ (2006) High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females. Br J Nutr 96:545-552
34. Battault S, Whiting SJ, Peltier SL, Sadrin S, Gerber G, Maixent JM (2013) Vitamin D metabolism, functions and needs: from science to health claims. Eur J Nutr 52:429-441. doi: 10.1007/s00394-012-0430-5
35. Blanco-Rojo R, Perez-Granados AM, Toxqui L, Gonzalez-Vizcayno C, Delgado MA, Vaquero MP (2011) Efficacy of a microencapsulated iron pyrophosphate- fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women. Br J Nutr 105:1652-1659. doi: 10.1017/ S0007114510005490