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Volumn 231, Issue 6, 2014, Pages 1079-1088

The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders

Author keywords

Autism; Induced pluripotent stem cells; SHANK3

Indexed keywords

BETA TUBULIN; BRACHYURY PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

EID: 84896722663     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3196-4     Document Type: Review
Times cited : (42)

References (75)
  • 2
    • 76549260925 scopus 로고    scopus 로고
    • Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
    • Aasen T, Izpisúa Belmonte JC (2010) Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc 5(2):371-382
    • (2010) Nat Protoc , vol.5 , Issue.2 , pp. 371-382
    • Aasen, T.1    Izpisúa Belmonte, J.C.2
  • 3
    • 0021330793 scopus 로고
    • Two monoclonal antibodies recognizing determinants on human embryonal carcinoma cells react specifically with the liver isozyme of human alkaline phosphatase
    • Andrews PW, Meyer LJ, Bednarz KL, Harris H (1984) Two monoclonal antibodies recognizing determinants on human embryonal carcinoma cells react specifically with the liver isozyme of human alkaline phosphatase. Hybridoma 3(1):33-39 (Pubitemid 14167480)
    • (1984) Hybridoma , vol.3 , Issue.1 , pp. 33-39
    • Andrews, P.W.1    Meyer, L.J.2    Bednarz, K.L.3    Harris, H.4
  • 4
    • 79955482429 scopus 로고    scopus 로고
    • Opportunities for use of human iPS cells in predictive toxicology
    • Anson BD, Kolaja KL, Kamp TJ (2011) Opportunities for use of human iPS cells in predictive toxicology. Clin Pharmacol Ther 89(5):754-758
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.5 , pp. 754-758
    • Anson, B.D.1    Kolaja, K.L.2    Kamp, T.J.3
  • 6
    • 0033997204 scopus 로고    scopus 로고
    • The amygdala theory of autism
    • Baron-Cohen (2000) The amygdala theory of autism. Neurosci Biobehav Rev 1-10
    • (2000) Neurosci Biobehav Rev , pp. 1-10
    • Baron-Cohen1
  • 8
    • 79952313620 scopus 로고    scopus 로고
    • Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting
    • Betancur C (2011) Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res 1380:42-77
    • (2011) Brain Res , vol.1380 , pp. 42-77
    • Betancur, C.1
  • 11
    • 73949128465 scopus 로고    scopus 로고
    • Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
    • doi:10.1542/peds.2009-1878C
    • Buie, T., Campbell, D.B., Fuchs, G. J., Furuta, G.T., Levy, J., Vande Water, J., et al. (2010). Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report. Pediatrics, 125(Supplement), S1 S18. doi:10.1542/peds.2009-1878C
    • (2010) Pediatrics , vol.125 , Issue.SUPPL.
    • Buie, T.1    Campbell, D.B.2    Fuchs, G.J.3    Furuta, G.T.4    Levy, J.5    Vande Water, J.6
  • 14
    • 0036677965 scopus 로고    scopus 로고
    • Cerebral lobes in autism: Early hyperplasia and abnormal age effects
    • Carper RA, Moses P, Tigue ZD, Courchesne E (2002) Cerebral lobes in autism: early hyperplasia and abnormal age effects. NeuroImage 16(4):1038-1051
    • (2002) NeuroImage , vol.16 , Issue.4 , pp. 1038-1051
    • Carper, R.A.1    Moses, P.2    Tigue, Z.D.3    Courchesne, E.4
  • 16
    • 75949087803 scopus 로고    scopus 로고
    • A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: Possible minicolumnar disruption due to an anatomical element in-common to multiple laminae
    • Casanova MF, El-Baz A, Vanbogaert E, Narahari P, Switala A (2010) A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae. Brain Pathol 20(2):451-458
    • (2010) Brain Pathol , vol.20 , Issue.2 , pp. 451-458
    • Casanova, M.F.1    El-Baz, A.2    Vanbogaert, E.3    Narahari, P.4    Switala, A.5
  • 17
  • 20
    • 84875825504 scopus 로고    scopus 로고
    • Translational animal models of autism and neurodevelopmental disorders
    • Crawley JN (2012) Translational animal models of autism and neurodevelopmental disorders. Dialogues Clin Neurosci 14(3):293-305
    • (2012) Dialogues Clin Neurosci , vol.14 , Issue.3 , pp. 293-305
    • Crawley, J.N.1
  • 22
    • 84862493260 scopus 로고    scopus 로고
    • Genetic architecture in autism spectrum disorder
    • Devlin B, Scherer SW (2012) Genetic architecture in autism spectrum disorder. Curr Opin Genet Dev 22(3):229-237
    • (2012) Curr Opin Genet Dev , vol.22 , Issue.3 , pp. 229-237
    • Devlin, B.1    Scherer, S.W.2
  • 24
    • 84855341900 scopus 로고    scopus 로고
    • SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
    • Durand CM, Perroy J, Loll F, Perrais D, Fagni L, Bourgeron T, Montcouquiol M, Sans N (2012) SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. Mol Psychiatry 17(1):71-84
    • (2012) Mol Psychiatry , vol.17 , Issue.1 , pp. 71-84
    • Durand, C.M.1    Perroy, J.2    Loll, F.3    Perrais, D.4    Fagni, L.5    Bourgeron, T.6    Montcouquiol, M.7    Sans, N.8
  • 25
    • 79953793127 scopus 로고    scopus 로고
    • Primary cells and stem cells in drug discovery: Emerging tools for high-throughput screening
    • Eglen R, Reisine T (2011) Primary cells and stem cells in drug discovery: emerging tools for high-throughput screening. Assay Drug Dev Technol 9(2):108-124
    • (2011) Assay Drug Dev Technol , vol.9 , Issue.2 , pp. 108-124
    • Eglen, R.1    Reisine, T.2
  • 26
    • 84872593582 scopus 로고    scopus 로고
    • Activity-dependent neuronal signalling and autism spectrum disorder
    • Ebert DH, Greenberg ME (2013) Activity-dependent neuronal signalling and autism spectrum disorder. Nature 493(7432):327-337
    • (2013) Nature , vol.493 , Issue.7432 , pp. 327-337
    • Ebert, D.H.1    Greenberg, M.E.2
  • 28
    • 84855931231 scopus 로고    scopus 로고
    • Pathways to drug development for autism spectrum disorders
    • Hampson DR, Gholizadeh S, Pacey LK (2012) Pathways to drug development for autism spectrum disorders. Clin Pharmacol Ther 91(2):189-200
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.2 , pp. 189-200
    • Hampson, D.R.1    Gholizadeh, S.2    Pacey, L.K.3
  • 30
    • 0018865014 scopus 로고
    • Calcium regulation of growth and differentiation of mouse epidermal cells in culture
    • Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19(1):245-254 (Pubitemid 10154229)
    • (1980) Cell , vol.19 , Issue.1 , pp. 245-254
    • Hennings, H.1    Michael, D.2    Cheng, C.3
  • 31
    • 67349257801 scopus 로고    scopus 로고
    • Thecytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements
    • Huett A, Leong JM, Podolsky DK, Xavier RJ (2009) Thecytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res 315(12):2001-2011
    • (2009) Exp Cell Res , vol.315 , Issue.12 , pp. 2001-2011
    • Huett, A.1    Leong, J.M.2    Podolsky, D.K.3    Xavier, R.J.4
  • 33
    • 84876070991 scopus 로고    scopus 로고
    • Modelling autism by SHANK gene mutations in mice
    • Jiang YH, Ehlers MD (2013) Modelling autism by SHANK gene mutations in mice. Neuron 78(1):8-27
    • (2013) Neuron , vol.78 , Issue.1 , pp. 8-27
    • Jiang, Y.H.1    Ehlers, M.D.2
  • 34
    • 79551594543 scopus 로고    scopus 로고
    • Toward fulfilling the promise of molecular medicine in fragile X syndrome
    • Krueger DD, Bear MF (2011) Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med 62:411-429
    • (2011) Annu Rev Med , vol.62 , pp. 411-429
    • Krueger, D.D.1    Bear, M.F.2
  • 36
    • 0027997172 scopus 로고
    • Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
    • DOI 10.1007/BF02172145
    • Lord C, Rutter M, Le Couteur A (1994) Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24(5):659-685 (Pubitemid 24309810)
    • (1994) Journal of Autism and Developmental Disorders , vol.24 , Issue.5 , pp. 659-685
    • Lord, C.1    Rutter, M.2    Couteur, A.L.3
  • 37
    • 56549127713 scopus 로고    scopus 로고
    • Guidelines and techniques for the generation of induced pluripotent stem cells
    • Maherali N, Hochedlinger K (2008) Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 3(6):595-605
    • (2008) Cell Stem Cell , vol.3 , Issue.6 , pp. 595-605
    • Maherali, N.1    Hochedlinger, K.2
  • 38
    • 84862551266 scopus 로고    scopus 로고
    • Modelling brain disease in a dish: Really?
    • Marchetto MC, Gage FH (2012) Modelling brain disease in a dish: really? Cell Stem Cell 10(6):642-645
    • (2012) Cell Stem Cell , vol.10 , Issue.6 , pp. 642-645
    • Marchetto, M.C.1    Gage, F.H.2
  • 41
    • 84865844893 scopus 로고    scopus 로고
    • Introduction to special issue on neuroimmunology in brain development and disease
    • McAllister AK, Patterson PH (2012) Introduction to special issue on neuroimmunology in brain development and disease. Dev Neurobiol 72(10):1269-1271
    • (2012) Dev Neurobiol , vol.72 , Issue.10 , pp. 1269-1271
    • McAllister, A.K.1    Patterson, P.H.2
  • 43
    • 77956634610 scopus 로고    scopus 로고
    • A call to standardize teratoma assays used to define human pluripotent cell lines
    • Müller FJ, Goldmann J, Löser P, Loring JF (2010) A call to standardize teratoma assays used to define human pluripotent cell lines. Cell Stem Cell 6(5):412-414
    • (2010) Cell Stem Cell , vol.6 , Issue.5 , pp. 412-414
    • Müller, F.J.1    Goldmann, J.2    Löser, P.3    Loring, J.F.4
  • 45
    • 84871777952 scopus 로고    scopus 로고
    • Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture
    • Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y (2012) Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture. PLoS One 7(12):e53024
    • (2012) PLoS One , vol.7 , Issue.12
    • Nasu, M.1    Takata, N.2    Danjo, T.3    Sakaguchi, H.4    Kadoshima, T.5    Futaki, S.6    Sekiguchi, K.7    Eiraku, M.8    Sasai, Y.9
  • 46
    • 84867006828 scopus 로고    scopus 로고
    • Autism spectrum disorders
    • Nightingale S (2012) Autism spectrum disorders. Nat Rev Drug Discov 11(10):745-746
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.10 , pp. 745-746
    • Nightingale, S.1
  • 47
    • 79953021243 scopus 로고    scopus 로고
    • Development of defective and persistent Sendai virus vector: A unique gene delivery/expression system ideal for cell reprogramming
    • Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y et al (2011) Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem 286(6):4760-4771
    • (2011) J Biol Chem , vol.286 , Issue.6 , pp. 4760-4771
    • Nishimura, K.1    Sano, M.2    Ohtaka, M.3    Furuta, B.4    Umemura, Y.5    Nakajima, Y.6
  • 48
    • 10344221119 scopus 로고    scopus 로고
    • Neuropathological findings in autism
    • DOI 10.1093/brain/awh287
    • Palmen SJ, van Engeland H, Hof PR, Schmitz C (2004) Neuropathological findings in autism. Brain 127(Pt 12):2572-2583 (Pubitemid 39627367)
    • (2004) Brain , vol.127 , Issue.12 , pp. 2572-2583
    • Palmen, S.J.M.C.1    Van Engeland, H.2    Hof, P.R.3    Schmitz, C.4
  • 49
    • 34547102737 scopus 로고    scopus 로고
    • Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage
    • DOI 10.1634/stemcells.2006-0707
    • Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC (2007) Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25(6):1511-1520 (Pubitemid 47106020)
    • (2007) Stem Cells , vol.25 , Issue.6 , pp. 1511-1520
    • Pankratz, M.T.1    Li, X.-J.2    LaVaute, T.M.3    Lyons, E.A.4    Chen, X.5    Zhang, S.-C.6
  • 50
    • 80052405826 scopus 로고    scopus 로고
    • Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector
    • Papapetrou EP, Sadelain M (2011) Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector. Nat Protoc 6(9):1251-1273
    • (2011) Nat Protoc , vol.6 , Issue.9 , pp. 1251-1273
    • Papapetrou, E.P.1    Sadelain, M.2
  • 51
    • 84856088804 scopus 로고    scopus 로고
    • Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
    • Paşca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Paşca AM et al (2011) Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Publ Group 17(12):1657-1662
    • (2011) Nat Publ Group , vol.17 , Issue.12 , pp. 1657-1662
    • Paşca, S.P.1    Portmann, T.2    Voineagu, I.3    Yazawa, M.4    Shcheglovitov, A.5    Paşca, A.M.6
  • 52
    • 84860172447 scopus 로고    scopus 로고
    • The 22q13.3 deletion syndrome (Phelan-McDermid syndrome)
    • Phelan K, McDermid HE (2012) The 22q13.3 deletion syndrome (Phelan-McDermid syndrome). Mol Syndromol 2(3-5):186-201
    • (2012) Mol Syndromol , vol.2 , Issue.3-5 , pp. 186-201
    • Phelan, K.1    McDermid, H.E.2
  • 53
    • 21344460723 scopus 로고    scopus 로고
    • When is the brain enlarged in autism? A meta-analysis of all brain size reports
    • DOI 10.1016/j.biopsych.2005.03.026, PII S0006322305003690
    • Redcay E, Courchesne E (2005) When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry 58(1):1-9 (Pubitemid 40909929)
    • (2005) Biological Psychiatry , vol.58 , Issue.1 , pp. 1-9
    • Redcay, E.1    Courchesne, E.2
  • 54
    • 33845427945 scopus 로고    scopus 로고
    • Expression of postsynaptic density proteins of the ProSAP/Shank family in the thymus
    • DOI 10.1007/s00418-006-0199-9
    • Redecker P, Bockmann J, Böckers TM (2006) Expression of postsynaptic density proteins of the ProSAP/Shank family in the thymus. Histochem Cell Biol 126(6):679-685 (Pubitemid 44899711)
    • (2006) Histochemistry and Cell Biology , vol.126 , Issue.6 , pp. 679-685
    • Redecker, P.1    Bockmann, J.2    Bockers, T.M.3
  • 55
    • 0022572835 scopus 로고
    • Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report
    • Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D, Ritvo A (1986) Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report. Am J Psychiatry 143(7):862-866 (Pubitemid 16090391)
    • (1986) American Journal of Psychiatry , vol.143 , Issue.7 , pp. 862-866
    • Ritvo, E.R.1    Freeman, B.J.2    Scheibel, A.B.3
  • 56
    • 84875666213 scopus 로고    scopus 로고
    • In utero exposure to valproic acid and autism-A current review of clinical and animal studies
    • Feb 8 [Epub ahead of print]
    • Roullet FI, Lai JK, Foster JA. In utero exposure to valproic acid and autism-A current review of clinical and animal studies. Neurotoxicol Teratol. 2013 Feb 8 [Epub ahead of print]
    • (2013) Neurotoxicol Teratol
    • Roullet, F.I.1    Lai, J.K.2    Foster, J.A.3
  • 57
  • 58
    • 84872534651 scopus 로고    scopus 로고
    • Cytosystems dynamics in self-organization of tissue architecture
    • Sasai Y (2013) Cytosystems dynamics in self-organization of tissue architecture. Nature 493(7432):318-326
    • (2013) Nature , vol.493 , Issue.7432 , pp. 318-326
    • Sasai, Y.1
  • 59
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
    • Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ (2012) Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat Neurosci 15(3):477-486
    • (2012) Nat Neurosci , vol.15 , Issue.3 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.4    Livesey, F.J.5
  • 61
    • 38949131937 scopus 로고    scopus 로고
    • Law should recognize value of interspecies embryos [1]
    • DOI 10.1038/451627a, PII 451627A
    • St John JC, Armstrong L, Minger SL, Campbell KH (2008) Law should recognize value of interspecies embryos. Nature 451(7179):627 (Pubitemid 351220543)
    • (2008) Nature , vol.451 , Issue.7179 , pp. 627
    • St, J.J.C.1    Armstrong, L.2    Minger, S.L.3    Campbell, K.H.S.4
  • 62
    • 31544468914 scopus 로고    scopus 로고
    • Generation of cerebellar neuron precursors from embryonic stem cells
    • DOI 10.1016/j.ydbio.2005.11.010, PII S0012160605007876
    • Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, Sasai Y (2006) Generation of cerebellar neuron precursors from embryonic stem cells. Dev Biol 290(2):287-296 (Pubitemid 43163492)
    • (2006) Developmental Biology , vol.290 , Issue.2 , pp. 287-296
    • Su, H.-L.1    Muguruma, K.2    Matsuo-Takasaki, M.3    Kengaku, M.4    Watanabe, K.5    Sasai, Y.6
  • 63
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663-676 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 64
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861-872 (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 65
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282(5391):1145-1147 (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 70
    • 53849140787 scopus 로고    scopus 로고
    • Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: A stereological experiment using calbindin-D28k
    • Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ (2008) Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum 7(3):406-416
    • (2008) Cerebellum , vol.7 , Issue.3 , pp. 406-416
    • Whitney, E.R.1    Kemper, T.L.2    Bauman, M.L.3    Rosene, D.L.4    Blatt, G.J.5
  • 72
    • 84878883307 scopus 로고    scopus 로고
    • A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS
    • doi:10.1016/j.stem.2013.04.003
    • Yang YM (2013) A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell S1934-5909(13):00139-2. doi:10.1016/j.stem.2013.04.003
    • (2013) Cell Stem Cell , vol.S1934-5909 , Issue.13 , pp. 00139-00142
    • Yang, Y.M.1
  • 73
  • 74
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, Thomson JA (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science 324(5928):797-801
    • (2009) Science , vol.324 , Issue.5928 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6    Thomson, J.A.7


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