LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation

Cellular Signalling

Volumn 26, Issue 5, 2014, Pages 1068-1074

  Chen, Jinxiao ^b   Yan, Hongwei ^b   Ren, Dan ni ^a   Yin, Yan ^a   Li, Zhi ^c   He, Qingqing ^b   Wo, Da ^b   Ho, Margaret Su chun ^b   Chen, Yihan ^a,b   Liu, Zhongmin ^a   Yang, Jianhua ^b   Liu, Shangfeng ^b   Zhu, Weidong ^a,b  

^a Key Laboratory of Arrhythmias of Ministry of Education   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Canonical Wnt pathway; Dimer; FPLC; Frizzled; LRP5 6

Indexed keywords

FRIZZLED PROTEIN; HOMODIMER; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PROTEIN FRZ8; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; BETA CATENIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5;

ARTICLE; CONFORMATIONAL TRANSITION; DIMERIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; LIGAND BINDING; PROTEIN BINDING; PROTEIN INTERACTION; WNT SIGNALING PATHWAY;

CANONICAL WNT PATHWAY; DIMER; FPLC; FRIZZLED; LRP5/6;

AMINO ACID SEQUENCE; BETA CATENIN; DIMERIZATION; FRIZZLED RECEPTORS; HEK293 CELLS; HEP G2 CELLS; HUMANS; LIGANDS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MOLECULAR SEQUENCE DATA; RECEPTORS, LDL; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 84896718474     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.12.020     Document Type: Article

References (25)

1. Clevers H. Cell 2006, 127:469-480.
2. MacDonald B.T., Tamai K., He X. Dev. Cell 2009, 17:9-26.
3. Tamai K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., Hess F., Saint-Jeannet J.P., He X. Nature 2000, 407:530-535.
4. Holmen S.L., Salic A., Zylstra C.R., Kirschner M.W., Williams B.O. J. Biol. Chem. 2002, 277:34727-34735.
5. Angers S., Moon R.T. Nat. Rev. Mol. Cell Biol. 2009, 10:468-477.
6. Bilic J., Huang Y.L., Davidson G., Zimmermann T., Cruciat C.M., Bienz M., Niehrs C. Science 2007, 316:1619-1622.
7. Cong F., Schweizer L., Varmus H. Development 2004, 131:5103-5115.
8. Chen S., Bubeck D., MacDonald B.T., Liang W.X., Mao J.H., Malinauskas T., Llorca O., Aricescu A.R., Siebold C., He X., Jones E.Y. Dev. Cell 2011, 21:848-861.
9. Bhanot P., Brink M., Samos C.H., Hsieh J.C., Wang Y., Macke J.P., Andrew D., Nathans J., Nusse R. Nature 1996, 382:225-230.
10. Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., Niehrs C. Nature 2001, 411:321-325.
11. Liu G., Bafico A., Harris V.K., Aaronson S.A. Mol. Cell. Biol. 2003, 23:5825-5835.
12. Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito A.T., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Nature 2008, 454:345-349.
13. Toomes C., Bottomley H.M., Jackson R.M., Towns K.V., Scott S., Mackey D.A., Craig J.E., Jiang L., Yang Z., Trembath R., Woodruff G., Gregory-Evans C.Y., Gregory-Evans K., Parker M.J., Black G.C., Downey L.M., Zhang K., Inglehearn C.F. Am. J. Hum. Genet. 2004, 74:721-730.
14. Fass D., Blacklow S., Kim P.S., Berger J.M. Nature 1997, 388:691-693.
15. Ai M., Heeger S., Bartels C.F., Schelling D.K., Osteoporosis-Pseudoglioma Collaborative Group Am. J. Hum. Genet. 2005, 77:741-753.
16. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., He X. Nature 2005, 438:873-877.
17. Tamai K., Zeng X., Liu C., Zhang X., Harada Y., Chang Z., He X. Mol. Cell 2004, 13:149-156.
18. Brennan K., Gonzalez-Sancho J.M., Castelo-Soccio L.A., Howe L.R., Brown A.M. Oncogene 2004, 23:4873-4884.
19. Pfleger K.D., Seeber R.M., Eidne K.A. Nat. Protoc. 2006, 1:337-345.
20. Grumolato L., Liu G., Mong P., Mudbhary R., Biswas R., Arroyave R., Vijayakumar S., Economides A.N., Aaronson S.A. Genes Dev. 2010, 24:2517-2530.
21. Zeng X., Huang H., Tamai K., Zhang X., Harada Y., Yokota C., Almeida K., Wang J., Doble B., Woodgett J., Wynshaw-Boris A., Hsieh J.C., He X. Development 2008, 135:367-375.
22. Naito A.T., Sumida T., Nomura S., Liu M.L., Higo T., Nakagawa A., Okada K., Sakai T., Hashimoto A., Hara Y., Shimizu I., Zhu W., Toko H., Katada A., Akazawa H., Oka T., Lee J.K., Minamino T., Nagai T., Walsh K., Kikuchi A., Matsumoto M., Botto M., Shiojima I., Komuro I. Cell 2012, 149:1298-1313.
23. Veeman M.T., Slusarski D.C., Kaykas A., Louie S.H., Moon R.T. Curr. Biol. 2003, 13:680-685.
24. He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H. Science 1997, 275:1652-1654.
25. Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., Delius H., Hoppe D., Stannek P., Walter C., Glinka A., Niehrs C. Nature 2002, 417:664-667.