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Volumn 65, Issue 1, 2014, Pages 11-16

Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus

Author keywords

Centenarians; Leptin gene (LEP); Leptin receptor gene (LEPR); Longevity; Myocardial infarction (MI); Polymorphism; Type 2 diabetes mellitus (DM2)

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

EID: 84896715893     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: 10.5603/EP.2014.0002     Document Type: Article
Times cited : (27)

References (54)
  • 1
    • 27744497128 scopus 로고    scopus 로고
    • Leptin: Structure, function and biology
    • Zhang F, Chen Y, Heiman M et al. Leptin: structure, function and biology. Vitam Horm 2005; 71: 345-372.
    • (2005) Vitam Horm , vol.71 , pp. 345-372
    • Zhang, F.1    Chen, Y.2    Heiman, M.3
  • 2
    • 33845642664 scopus 로고    scopus 로고
    • The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review
    • Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007; 8: 21-34.
    • (2007) Obes Rev , vol.8 , pp. 21-34
    • Klok, M.D.1    Jakobsdottir, S.2    Drent, M.L.3
  • 4
    • 0038723695 scopus 로고    scopus 로고
    • Role of leptin as an immunomodulator of blood mononuclear cells: Mechanisms of action
    • Sánchez-Margalet V, Martín-Romero C, Santos-Alvarez J et al. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol 2003; 133: 11-19.
    • (2003) Clin Exp Immunol , vol.133 , pp. 11-19
    • Sánchez-Margalet, V.1    Martín-Romero, C.2    Santos-Alvarez, J.3
  • 5
    • 2942674439 scopus 로고    scopus 로고
    • Leptin and bone metabolism
    • Coen G. Leptin and bone metabolism. J Nephrol 2004; 17: 187-189.
    • (2004) J Nephrol , vol.17 , pp. 187-189
    • Coen, G.1
  • 6
    • 83255188687 scopus 로고    scopus 로고
    • Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women
    • Koroglu BK, Kiris F, Ersoy IH et al. Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women. Endokrynol Pol 2011; 62: 429-435.
    • (2011) Endokrynol Pol , vol.62 , pp. 429-435
    • Koroglu, B.K.1    Kiris, F.2    Ersoy, I.H.3
  • 7
    • 0035125097 scopus 로고    scopus 로고
    • Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo
    • Cases JA, Gabriely I, Ma XH et al. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 2001; 50: 348-352.
    • (2001) Diabetes , vol.50 , pp. 348-352
    • Cases, J.A.1    Gabriely, I.2    Ma, X.H.3
  • 8
    • 79960818482 scopus 로고    scopus 로고
    • The role of leptin in the regulation of carbohydrate metabolism
    • Tucholski K, Otto-Buczkowska E. The role of leptin in the regulation of carbohydrate metabolism. Endokrynol Pol 2011; 62: 258-262.
    • (2011) Endokrynol Pol , vol.62 , pp. 258-262
    • Tucholski, K.1    Otto-Buczkowska, E.2
  • 11
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437-446.
    • (2000) J Leukoc Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 12
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Frühbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006; 393: 7-20.
    • (2006) Biochem J , vol.393 , pp. 7-20
    • Frühbeck, G.1
  • 13
    • 0035092710 scopus 로고    scopus 로고
    • Serum leptin levels in the elderly: Relationship with gender and nutritional status
    • Smirnoff P, Almiral-Seliger D, Schwartz B. Serum leptin levels in the elderly: relationship with gender and nutritional status. J Nutr Health Aging 2001; 5: 29-32.
    • (2001) J Nutr Health Aging , vol.5 , pp. 29-32
    • Smirnoff, P.1    Almiral-Seliger, D.2    Schwartz, B.3
  • 14
    • 4544235466 scopus 로고    scopus 로고
    • Serum leptin concentrations and body adipose measures in older black and white adults
    • Ruhl CE, Everhart JE, Ding J et al. Serum leptin concentrations and body adipose measures in older black and white adults. Am J Clin Nutr 2004; 80: 576-583.
    • (2004) Am J Clin Nutr , vol.80 , pp. 576-583
    • Ruhl, C.E.1    Everhart, J.E.2    Ding, J.3
  • 15
    • 0034457109 scopus 로고    scopus 로고
    • Leptin and aging: Correlation with endocrine changes in male and female healthy adult populations of different body weights
    • Isidori AM, Strollo F, Morè M et al. Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin Endocrinol Metab 2000; 85: 1954-1962.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1954-1962
    • Isidori, A.M.1    Strollo, F.2    Morè, M.3
  • 16
    • 0036265354 scopus 로고    scopus 로고
    • Aging is associated with resistance to effects of leptin on fat distribution and insulin action
    • Ma XH, Muzumdar R, Yang XM et al. Aging is associated with resistance to effects of leptin on fat distribution and insulin action. J Gerontol A Biol Sci Med Sci 2002; 57: B225-B231.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Ma, X.H.1    Muzumdar, R.2    Yang, X.M.3
  • 17
    • 0035844031 scopus 로고    scopus 로고
    • Leptin enhances the calcification of vascular cells: Artery wall as a target of leptin
    • Parhami F, Tintut Y, Ballard A et al. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res 2001; 88: 954-960.
    • (2001) Circ Res , vol.88 , pp. 954-960
    • Parhami, F.1    Tintut, Y.2    Ballard, A.3
  • 18
    • 3242891548 scopus 로고    scopus 로고
    • Identifying pathways involved in leptin-dependent aggregation of human platelets
    • Corsonello A, Malara A, De Domenico D et al. Identifying pathways involved in leptin-dependent aggregation of human platelets. Int J Obes Relat Metab Disord 2004; 28: 979-984.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 979-984
    • Corsonello, A.1    Malara, A.2    De Domenico, D.3
  • 19
    • 2942604874 scopus 로고    scopus 로고
    • Circulating leptin is associated with oxidized LDL in postmenopausal women
    • Porreca E, Di Febbo C, Moretta V et al. Circulating leptin is associated with oxidized LDL in postmenopausal women. Atherosclerosis 2004; 175: 139-143.
    • (2004) Atherosclerosis , vol.175 , pp. 139-143
    • Porreca, E.1    Di Febbo, C.2    Moretta, V.3
  • 21
    • 0031464354 scopus 로고    scopus 로고
    • Body composition and age in African-American and Caucasian women: Relationship to plasma leptin levels
    • Perry HM 3rd, Morley JE, Horowitz M et al. Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism 1997; 46: 1399-1405.
    • (1997) Metabolism , vol.46 , pp. 1399-1405
    • Perry III, H.M.1    Morley, J.E.2    Horowitz, M.3
  • 22
    • 49749107875 scopus 로고    scopus 로고
    • Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: New therapeutic approaches
    • Kalra SP. Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 2008; 24: 820-826.
    • (2008) Nutrition , vol.24 , pp. 820-826
    • Kalra, S.P.1
  • 23
    • 58549090318 scopus 로고    scopus 로고
    • Hyperleptinemia as a robust risk factor of coronary artery disease and metabolic syndrome in type 2 diabetic patients
    • Kim SK, Kim HJ, Ahn CW et al. Hyperleptinemia as a robust risk factor of coronary artery disease and metabolic syndrome in type 2 diabetic patients. Endocr J 2008; 55: 1085-1092.
    • (2008) Endocr J , vol.55 , pp. 1085-1092
    • Kim, S.K.1    Kim, H.J.2    Ahn, C.W.3
  • 25
    • 84870920267 scopus 로고    scopus 로고
    • Adiponectin, leptin, resistin and insulin blood concentrations in patients with ischaemic cerebral stroke
    • Bienek R, Marek B, Kajdaniuk D et al. Adiponectin, leptin, resistin and insulin blood concentrations in patients with ischaemic cerebral stroke. Endokrynol Pol 2012; 63: 338-345.
    • (2012) Endokrynol Pol , vol.63 , pp. 338-345
    • Bienek, R.1    Marek, B.2    Kajdaniuk, D.3
  • 26
    • 0037298896 scopus 로고    scopus 로고
    • Inverse correlation between serum leptin concentration and vertebral bone density in postmenopausal women
    • Ushiroyama T, Ikeda A, Hosotani T et al. Inverse correlation between serum leptin concentration and vertebral bone density in postmenopausal women. Gynecol Endocrinol 2003; 17: 31-36.
    • (2003) Gynecol Endocrinol , vol.17 , pp. 31-36
    • Ushiroyama, T.1    Ikeda, A.2    Hosotani, T.3
  • 28
    • 39149085661 scopus 로고    scopus 로고
    • Polish centenarians programme. Multidisciplinary studies of successful ageing: Aims, methods, and preliminary results
    • Mossakowska M, Barcikowska M, Broczek K et al. Polish Centenarians Programme. Multidisciplinary studies of successful ageing: aims, methods, and preliminary results. Exp Gerontol 2008; 43: 238-244.
    • (2008) Exp Gerontol , vol.43 , pp. 238-244
    • Mossakowska, M.1    Barcikowska, M.2    Broczek, K.3
  • 29
    • 80855132443 scopus 로고    scopus 로고
    • Medical, psychological and socioeconomic aspects of aging in Poland: Assumptions and objectives of the PolSenior project
    • Bledowski P, Mossakowska M, Chudek J et al. Medical, psychological and socioeconomic aspects of aging in Poland: assumptions and objectives of the PolSenior project. Exp Gerontol 2011; 46: 1003-1009.
    • (2011) Exp Gerontol , vol.46 , pp. 1003-1009
    • Bledowski, P.1    Mossakowska, M.2    Chudek, J.3
  • 30
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988; 16: 1215.
    • (1988) Nucl Acids Res , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 32
    • 34047260050 scopus 로고    scopus 로고
    • Neuroendocrine control of metabolic homeostasis in Polish centenarians
    • Baranowska B, Bik W, Baranowska-Bik A et al. Neuroendocrine control of metabolic homeostasis in Polish centenarians. J Physiol Pharmacol 2006; 57 (Suppl. 6): 55-61.
    • (2006) J Physiol Pharmacol , vol.57 , Issue.SUPPL. 6 , pp. 55-61
    • Baranowska, B.1    Bik, W.2    Baranowska-Bik, A.3
  • 33
    • 0034527931 scopus 로고    scopus 로고
    • Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight
    • Mammès O, Betoulle D, Aubert R et al. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann Hum Genet 2000; 64: 391-394.
    • (2000) Ann Hum Genet , vol.64 , pp. 391-394
    • Mammès, O.1    Betoulle, D.2    Aubert, R.3
  • 34
    • 33748194234 scopus 로고    scopus 로고
    • G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
    • Wang TN, Huang MC, Chang WT et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity 2006; 14: 183-187.
    • (2006) Obesity , vol.14 , pp. 183-187
    • Wang, T.N.1    Huang, M.C.2    Chang, W.T.3
  • 35
    • 2942602689 scopus 로고    scopus 로고
    • Body mass index, leptin and leptin receptor polymorphisms, and non-Hodgkin lymphoma
    • Skibola CF, Holly EA, Forrest MS et al. Body mass index, leptin and leptin receptor polymorphisms, and non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 2004; 13: 779-786.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 779-786
    • Skibola, C.F.1    Holly, E.A.2    Forrest, M.S.3
  • 36
    • 1942507889 scopus 로고    scopus 로고
    • Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease
    • Ribeiro R, Vasconcelos A, Costa S et al. Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate 2004; 59: 268-274.
    • (2004) Prostate , vol.59 , pp. 268-274
    • Ribeiro, R.1    Vasconcelos, A.2    Costa, S.3
  • 37
    • 33646414773 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer
    • Ribeiro R, Araújo AP, Coelho A et al. A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. Eur J Cancer 2006; 42: 1188-1193.
    • (2006) Eur J Cancer , vol.42 , pp. 1188-1193
    • Ribeiro, R.1    Araújo, A.P.2    Coelho, A.3
  • 38
    • 33644883030 scopus 로고    scopus 로고
    • Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma
    • Snoussi K, Strosberg AD, Bouaouina N et al. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer 2006; 6: 38.
    • (2006) BMC Cancer , vol.6 , pp. 38
    • Snoussi, K.1    Strosberg, A.D.2    Bouaouina, N.3
  • 39
    • 58149381884 scopus 로고    scopus 로고
    • Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: A case control study
    • Okobia MN, Bunker CH, Garte SJ et al. Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control study. BMC Cancer 2008; 8: 338.
    • (2008) BMC Cancer , vol.8 , pp. 338
    • Okobia, M.N.1    Bunker, C.H.2    Garte, S.J.3
  • 40
    • 64849109418 scopus 로고    scopus 로고
    • Associations among lipids, leptin, and leptin receptor gene Gln223Arg polymorphisms and breast cancer in China
    • Han CZ, Du LL, Jing JX et al. Associations among lipids, leptin, and leptin receptor gene Gln223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res 2008; 126: 38-48.
    • (2008) Biol Trace Elem Res , vol.126 , pp. 38-48
    • Han, C.Z.1    Du, L.L.2    Jing, J.X.3
  • 41
    • 61449257383 scopus 로고    scopus 로고
    • Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer
    • Yapijakis C, Kechagiadakis M, Nkenke E et al. Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. J Cancer Res Clin Oncol 2009; 135: 603-612.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 603-612
    • Yapijakis, C.1    Kechagiadakis, M.2    Nkenke, E.3
  • 42
    • 79954521474 scopus 로고    scopus 로고
    • Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients
    • Partida-Pérez M, de la Luz Ayala-Madrigal M, Peregrina-Sandoval J et al. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark 2010; 7: 117-121.
    • (2010) Cancer Biomark , vol.7 , pp. 117-121
    • Partida-Pérez, M.1    Delaluz Ayala-Madrigal, M.2    Peregrina-Sandoval, J.3
  • 43
    • 80052611373 scopus 로고    scopus 로고
    • Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
    • Nyante SJ, Gammon MD, Kaufman JS et al. Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes. Breast Cancer Res Treat 2011; 129: 593-606.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 593-606
    • Nyante, S.J.1    Gammon, M.D.2    Kaufman, J.S.3
  • 44
    • 48349084217 scopus 로고    scopus 로고
    • Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity
    • Mizuta E, Kokubo Y, Yamanaka I et al. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens Res 2008; 31: 1069-1077.
    • (2008) Hypertens Res , vol.31 , pp. 1069-1077
    • Mizuta, E.1    Kokubo, Y.2    Yamanaka, I.3
  • 45
    • 30544443607 scopus 로고    scopus 로고
    • Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study
    • Salopuro T, Pulkkinen L, Lindström J et al. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: the Finnish Diabetes Prevention Study. Int J Obes 2005; 29: 1245-1251.
    • (2005) Int J Obes , vol.29 , pp. 1245-1251
    • Salopuro, T.1    Pulkkinen, L.2    Lindström, J.3
  • 46
    • 0034847530 scopus 로고    scopus 로고
    • The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability
    • Yiannakouris N, Yannakoulia M, Melistas L et al. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001; 86: 4434-4439.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4434-4439
    • Yiannakouris, N.1    Yannakoulia, M.2    Melistas, L.3
  • 47
    • 48349132166 scopus 로고    scopus 로고
    • Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    • Masuo K, Straznicky NE, Lambert GW et al. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 2008; 31: 1093-1100.
    • (2008) Hypertens Res , vol.31 , pp. 1093-1100
    • Masuo, K.1    Straznicky, N.E.2    Lambert, G.W.3
  • 48
    • 68549133296 scopus 로고    scopus 로고
    • Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly
    • Gottlieb MG, Bodanese LC, Araújo Leite LE et al. Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. Metab Syndr Relat Disord 2009; 7: 341-348.
    • (2009) Metab Syndr Relat Disord , vol.7 , pp. 341-348
    • Gottlieb, M.G.1    Bodanese, L.C.2    Araújo Leite, L.E.3
  • 49
    • 2942718557 scopus 로고    scopus 로고
    • Association of leptin receptor polymorphism with insulin resistance
    • Chiu KC, Chu A, Chuang LM et al. Association of leptin receptor polymorphism with insulin resistance. Eur J Endocrinol 2004; 150: 725-729.
    • (2004) Eur J Endocrinol , vol.150 , pp. 725-729
    • Chiu, K.C.1    Chu, A.2    Chuang, L.M.3
  • 50
    • 10744223625 scopus 로고    scopus 로고
    • Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men
    • Takahashi-Yasuno A, Masuzaki H, Miyawaki T et al. Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res Clin Pract 2003; 62: 169-175.
    • (2003) Diabetes Res Clin Pract , vol.62 , pp. 169-175
    • Takahashi-Yasuno, A.1    Masuzaki, H.2    Miyawaki, T.3
  • 51
    • 58849113457 scopus 로고    scopus 로고
    • The 223A > G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease
    • Sun YM, Wang LF, Li J et al. The 223A > G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease. Eur J Clin Pharmacol 2009; 65: 157-161.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 157-161
    • Sun, Y.M.1    Wang, L.F.2    Li, J.3
  • 52
    • 25844496292 scopus 로고    scopus 로고
    • Normal fasting plasma glucose levels and type 2 diabetes in young men
    • Tirosh A, Shai I, Tekes-Manova D et al. Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 2005; 353: 1454-1462.
    • (2005) N Engl J Med , vol.353 , pp. 1454-1462
    • Tirosh, A.1    Shai, I.2    Tekes-Manova, D.3
  • 53
    • 34548167264 scopus 로고    scopus 로고
    • Normal fasting plasma glucose levels and type 2 diabetes: The high-risk and population strategy for occupational health promotion (HIPOP-OHP) [corrected] study
    • Hayashino Y, Fukuhara S, Suzukamo Y et al. Normal fasting plasma glucose levels and type 2 diabetes: the high-risk and population strategy for occupational health promotion (HIPOP-OHP) [corrected] study. Acta Diabetol 2007; 44: 164-166.
    • (2007) Acta Diabetol , vol.44 , pp. 164-166
    • Hayashino, Y.1    Fukuhara, S.2    Suzukamo, Y.3
  • 54
    • 43949090154 scopus 로고    scopus 로고
    • Normal fasting plasma glucose and risk of type 2 diabetes diagnosis
    • Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008; 121: 519-524.
    • (2008) Am J Med , vol.121 , pp. 519-524
    • Nichols, G.A.1    Hillier, T.A.2    Brown, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.