Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease

Environmental and Molecular Mutagenesis

Volumn 55, Issue 3, 2014, Pages 223-230

  Liu, Xin ^a   Chen, Qi ^a   Tsai, Hui Ju ^a,b,c   Wang, Guoying ^d   Hong, Xiumei ^d   Zhou, Ying ^e   Zhang, Chunling ^f   Liu, Chunyu ^f   Liu, Rong ^a   Wang, Hongjian ^a   Zhang, Shanchun ^a   Yu, Yunxian ^a   Mestan, Karen K ^a   Pearson, Colleen ^g   Otlans, Peters ^g   Zuckerman, Barry ^g   Wang, Xiaobin ^a,d,h  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Institute of Population Health Sciences   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e CHILDREN'S MEMORIAL HOSPITAL   (United States)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cord blood; DNA methylation; Early life origins of disease; Maternal BMI

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE LIKE 2; ADENYLATE CYCLASE; ADENYLATE CYCLASE 3; ANAPHASE PROMOTING COMPLEX SUBUNIT 7; ANGIOPOIETIN; ANGIOPOIETIN LIKE 2 PROTEIN; CALCIUM BINDING PROTEIN; CALCIUM BINDING PROTEIN 39; CHROMOSOME 18 OPEN READING FRAME 8; DOCKING PROTEIN; DOCKING PROTEIN 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR C GROUP 5 MEMBER B; GERM CELL ASSOCIATED 2; MITOCHONDRIAL RIBOSOMAL PROTEIN L35; PLACENTA SPECIFIC 1; POGO TRANSPOSABLE ELEMENT WITH ZNF DOMAIN; PROLINE; PROLINE RICH 16; PROTEIN; TRANSCRIPTION FACTOR HEYL; UNCLASSIFIED DRUG; WNT PROTEIN; WNT16 PROTEIN; ZINC FINGER CCHC DOMAIN CONTAINING 10; ZINC FINGER PROTEIN; ZINC FINGER WITH KRAB AND SCAN DOMAIN 5;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CPG ISLAND; DISEASE PREDISPOSITION; DNA METHYLATION; EPIGENETICS; FEMALE; GENE MAPPING; HUMAN; LIFESPAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL CARE; MATERNAL OBESITY; MATERNAL PREPREGNANCY BODY MASS INDEX; PROGENY; PROMOTER REGION; QUALITY CONTROL; TUMOR GENE; UMBILICAL CORD BLOOD; WEIGHT CONTROL;

CORD BLOOD; DNA METHYLATION; EARLY LIFE ORIGINS OF DISEASE; MATERNAL BMI;

ADULT; BODY MASS INDEX; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION; HUMANS; INFANT, NEWBORN; LIPIDS; MALE; MOTHERS; NEOPLASMS; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PREGNANCY COMPLICATIONS; QUALITY CONTROL; REGRESSION ANALYSIS; YOUNG ADULT;

EID: 84896712548     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21827     Document Type: Article

References (39)

1. Adkins RM, Krushkal J, Tylavsky FA, Thomas F. 2011a. Racial differences in gene-specific DNA methylation levels are present at birth. Birth Defects Res A Clin Mol Teratol 91:728-736.
2. Adkins RM, Thomas F, Tylavsky FA, Krushkal J. 2011b. Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med Genet 12:47.
3. Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, et al. 2010. Identification of DOK genes as lung tumor suppressors. Nat Genet 42:216-223.
4. Buss C, Entringer S, Davis EP, Hobel CJ, Swanson JM, Wadhwa PD, Sandman CA. 2012. Impaired executive function mediates the association between maternal pre-pregnancy body mass index and child ADHD symptoms. PLoS One 7:e37758.
5. Chen YA, Choufani S, Ferreira JC, Grafodatskaya D, Butcher DT, Weksberg R. 2011. Sequence overlap between autosomal and sex-linked probes on the Illumina HumanMethylation27 microarray. Genomics 97:214-222.
6. Dabelea D, Mayer-Davis EJ, Lamichhane AP, D'Agostino RB, Jr., Liese AD, Vehik KS, Narayan KM, Zeitler P, Hamman RF. 2008. Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: The SEARCH Case-Control Study. Diabetes Care 31:1422-1426.
7. Fant M, Farina A, Nagaraja R, Schlessinger D. 2010. PLAC1 (Placenta-specific 1): A novel, X-linked gene with roles in reproductive and cancer biology. Prenat Diagn 30:497-502.
8. Feinberg AP. 2008. Epigenetics at the epicenter of modern medicine. JAMA 299:1345-1350.
9. Golbabapour S, Abdulla MA, Hajrezaei M. 2011. A concise review on epigenetic regulation: Insight into molecular mechanisms. Int J Mol Sci 12:8661-8694.
10. Gong L, Pan YX, Chen H. 2010. Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation. Epigenetics 5:619-626.
11. Hussain N. 2012. Epigenetic influences that modulate infant growth, development, and disease. Antioxid Redox Signal 17:224-236.
12. Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. 2013. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environ Health Perspect 121:971-977.
13. Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, Hertz-Picciotto I. 2012. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 129:e1121-e1128.
14. Kulie T, Slattengren A, Redmer J, Counts H, Eglash A, Schrager S. 2011. Obesity and women's health: An evidence-based review. J Am Board Fam Med 24:75-85.
15. Kumar R, Story RE, Pongracic JA, Hong X, Arguelles L, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, et al. 2010. Maternal pre-pregnancy obesity and recurrent wheezing in early childhood. Pediatr Allergy Immunol Pulmonol 23:183-190.
16. Lee H, Jaffe AE, Feinberg JI, Tryggvadottir R, Brown S, Montano C, Aryee MJ, Irizarry RA, Herbstman J, Witter FR, et al. 2012. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. Int J Epidemiol 41:188-199.
17. Liu J, Morgan M, Hutchison K, Calhoun VD. 2010. A study of the influence of sex on genome wide methylation. PLoS One 5:e10028.
18. Liu X, Wang G, Hong X, Wang D, Tsai HJ, Zhang S, Arguelles L, Kumar R, Wang H, Liu R, et al. 2011. Gene-vitamin D interactions on food sensitization: A prospective birth cohort study. Allergy 66:1442-1448.
19. Manoukian AS, Woodgett JR. 2002. Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways. Adv Cancer Res 84:203-229.
20. Michels KB, Harris HR, Barault L. 2011. Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements. PLoS One 6:e25254.
21. Milagro FI, Campion J, Garcia-Diaz DF, Goyenechea E, Paternain L, Martinez JA. 2009. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J Physiol Biochem 65:1-9.
22. Nam D, Kim J, Kim SY, Kim S. 2010. GSA-SNP: A general approach for gene set analysis of polymorphisms. Nucleic Acids Res 38(Web Server issue):W749-W754.
23. Reynolds RM, Allan KM, Raja EA, Bhattacharya S, McNeill G, Hannaford PC, Sarwar N, Lee AJ, Bhattacharya S, Norman JE. 2013. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: Follow-up of 1 323 275 person years. BMJ 347:f4539.
24. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, et al. 2005. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437:1173-1178.
25. Schroeder JW, Conneely KN, Cubells JC, Kilaru V, Newport DJ, Knight BT, Stowe ZN, Brennan PA, Krushkal J, Tylavsky FA, et al. 2011. Neonatal DNA methylation patterns associate with gestational age. Epigenetics 6:1498-1504.
26. Schroeder JW, Smith AK, Brennan PA, Conneely KN, Kilaru V, Knight BT, Newport DJ, Cubells JF, Stowe ZN. 2012. DNA methylation in neonates born to women receiving psychiatric care. Epigenetics 7:409-414.
27. Simmen FA, Simmen RC. 2011. The maternal womb: A novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev 20:539-548.
28. Smith AK, Conneely KN, Newport DJ, Kilaru V, Schroeder JW, Pennell PB, Knight BT, Cubells JC, Stowe ZN, Brennan PA. 2012. Prenatal antiepileptic exposure associates with neonatal DNA methylation differences. Epigenetics 7:458-463.
29. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, et al. 2005. A human protein-protein interaction network: A resource for annotating the proteome. Cell 122:957-968.
30. Stuebe AM, Forman MR, Michels KB. 2009. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter. Int J Obes 33:743-752.
31. Swanson JM, Entringer S, Buss C, Wadhwa PD. 2009. Developmental origins of health and disease: Environmental exposures. Semin Reprod Med 27:391-402.
32. Wadhwa PD, Buss C, Entringer S, Swanson JM. 2009. Developmental origins of health and disease: Brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med 27:358-368.
33. Wadugu B, Kuhn B. 2012. The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. Am J Physiol Heart Circ Physiol 302:H2139-H2147.
34. Wang X, Zuckerman B, Pearson C, Kaufman G, Chen C, Wang G, Niu T, Wise PH, Bauchner H, Xu X. 2002. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA 287:195-202.
35. Wang D, Liu X, Zhou Y, Xie H, Hong X, Tsai HJ, Wang G, Liu R, Wang X. 2012. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics 7:594-605.
36. Widiker S, Karst S, Wagener A, Brockmann GA. 2010. High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines. J Appl Genet 51:193-197.
37. Xu X, Li W, Fan X, Liang Y, Zhao M, Zhang J, Liang Y, Tong W, Wang J, Yang W, et al. 2007. Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer. Oncogene 26:7371-7379.
38. Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, Craig DW, Redman M, Gershon ES, Liu C. 2010. Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86:411-419.
39. Zheng HF, Tobias JH, Duncan E, Evans DM, Eriksson J, Paternoster L, Yerges-Armstrong LM, Lehtimaki T, Bergstrom U, Kahonen M, et al. 2012. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet 8:e1002745.