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Volumn 33, Issue 3, 2014, Pages 313-324

Heterogeneity among septic shock patients in a set of immunoregulatory markers

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD163 ANTIGEN; CD40 ANTIGEN; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOCYTE SURFACE MARKER; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84896708263     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-013-1957-y     Document Type: Article
Times cited : (14)

References (41)
  • 1
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • 12700374 10.1056/NEJMoa022139
    • Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348(16):1546-1554
    • (2003) N Engl J Med , vol.348 , Issue.16 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 2
    • 33749027114 scopus 로고    scopus 로고
    • The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: Secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database
    • 16542492 10.1186/cc4854
    • Harrison DA, Welch CA, Eddleston JM (2006) The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 10(2):R42
    • (2006) Crit Care , vol.10 , Issue.2 , pp. 42
    • Harrison, D.A.1    Welch, C.A.2    Eddleston, J.M.3
  • 3
    • 63149115281 scopus 로고    scopus 로고
    • The burden of sepsis-associated mortality in the United States from 1999 to 2005: An analysis of multiple-cause-of-death data
    • 19250547 10.1186/cc7733
    • Melamed A, Sorvillo FJ (2009) The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data. Crit Care 13(1):R28
    • (2009) Crit Care , vol.13 , Issue.1 , pp. 28
    • Melamed, A.1    Sorvillo, F.J.2
  • 4
    • 80052731974 scopus 로고    scopus 로고
    • Current insights in sepsis: From pathogenesis to new treatment targets
    • 21900767 10.1097/MCC.0b013e32834a4aeb
    • Wiersinga WJ (2011) Current insights in sepsis: from pathogenesis to new treatment targets. Curr Opin Crit Care 17(5):480-486
    • (2011) Curr Opin Crit Care , vol.17 , Issue.5 , pp. 480-486
    • Wiersinga, W.J.1
  • 5
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • 1:CAS:528:DC%2BD3sXhtlCitA%3D%3D 12519925 10.1056/NEJMra021333
    • Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348(2):138-150
    • (2003) N Engl J Med , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 6
    • 13244288781 scopus 로고    scopus 로고
    • The "cytokine profile": A code for sepsis
    • 1:CAS:528:DC%2BD2MXhtVGqs70%3D 15694867 10.1016/j.molmed.2004.12.007
    • Ulloa L, Tracey KJ (2005) The "cytokine profile": a code for sepsis. Trends Mol Med 11(2):56-63
    • (2005) Trends Mol Med , vol.11 , Issue.2 , pp. 56-63
    • Ulloa, L.1    Tracey, K.J.2
  • 7
    • 77954183132 scopus 로고    scopus 로고
    • Immunotherapy for sepsis - A new approach against an ancient foe
    • 1:CAS:528:DC%2BC3cXpslyjt78%3D 20592301 10.1056/NEJMcibr1004371
    • Hotchkiss RS, Opal S (2010) Immunotherapy for sepsis - a new approach against an ancient foe. N Engl J Med 363(1):87-89
    • (2010) N Engl J Med , vol.363 , Issue.1 , pp. 87-89
    • Hotchkiss, R.S.1    Opal, S.2
  • 8
    • 84255183707 scopus 로고    scopus 로고
    • The search for effective therapy for sepsis: Back to the drawing board?
    • 1:CAS:528:DC%2BC3MXhs1OhtbfM 22187284 10.1001/jama.2011.1853
    • Angus DC (2011) The search for effective therapy for sepsis: back to the drawing board? JAMA 306(23):2614-2615
    • (2011) JAMA , vol.306 , Issue.23 , pp. 2614-2615
    • Angus, D.C.1
  • 9
    • 84861706642 scopus 로고    scopus 로고
    • Septic shock - Evaluating another failed treatment
    • 1:CAS:528:DC%2BC38XosFOksLc%3D 22616829 10.1056/NEJMe1203412
    • Wenzel RP, Edmond MB (2012) Septic shock - evaluating another failed treatment. N Engl J Med 366(22):2122-2124
    • (2012) N Engl J Med , vol.366 , Issue.22 , pp. 2122-2124
    • Wenzel, R.P.1    Edmond, M.B.2
  • 10
    • 84862908403 scopus 로고    scopus 로고
    • A genomic storm in critically injured humans
    • 1:CAS:528:DC%2BC3MXhs12nt73O 3244029 22110166 10.1084/jem.20111354
    • Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H et al (2011) A genomic storm in critically injured humans. J Exp Med 208(13):2581-2590
    • (2011) J Exp Med , vol.208 , Issue.13 , pp. 2581-2590
    • Xiao, W.1    Mindrinos, M.N.2    Seok, J.3    Cuschieri, J.4    Cuenca, A.G.5    Gao, H.6
  • 11
    • 84255193988 scopus 로고    scopus 로고
    • Immunosuppression in sepsis
    • 1:CAS:528:DC%2BC3MXhs1Ohur3K 22187286 10.1001/jama.2011.1831
    • Ward PA (2011) Immunosuppression in sepsis. JAMA 306(23):2618-2619
    • (2011) JAMA , vol.306 , Issue.23 , pp. 2618-2619
    • Ward, P.A.1
  • 12
    • 57349140752 scopus 로고    scopus 로고
    • Downregulation of CD40 ligand response in monocytes from sepsis patients
    • 1:CAS:528:DC%2BD1cXhsFWktb%2FP 2593171 18945879 10.1128/CVI.00184-08
    • Sinistro A, Almerighi C, Ciaprini C, Natoli S, Sussarello E, Di Fino S et al (2008) Downregulation of CD40 ligand response in monocytes from sepsis patients. Clin Vaccine Immunol 15(12):1851-1858
    • (2008) Clin Vaccine Immunol , vol.15 , Issue.12 , pp. 1851-1858
    • Sinistro, A.1    Almerighi, C.2    Ciaprini, C.3    Natoli, S.4    Sussarello, E.5    Di Fino, S.6
  • 13
    • 81855185336 scopus 로고    scopus 로고
    • Advances in the management of sepsis and the understanding of key immunologic defects
    • 1:CAS:528:DC%2BC3MXhsFant77L 3433833 21952252
    • Skrupky LP, Kerby PW, Hotchkiss RS (2011) Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology 115(6):1349-1362
    • (2011) Anesthesiology , vol.115 , Issue.6 , pp. 1349-1362
    • Skrupky, L.P.1    Kerby, P.W.2    Hotchkiss, R.S.3
  • 14
    • 82355173296 scopus 로고    scopus 로고
    • New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis
    • 21840338 10.1016/j.jinf.2011.08.004
    • Huttunen R, Aittoniemi J (2011) New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis. J Infect 63(6):407-419
    • (2011) J Infect , vol.63 , Issue.6 , pp. 407-419
    • Huttunen, R.1    Aittoniemi, J.2
  • 15
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    • 1:STN:280:DyaK1MznsVCrsg%3D%3D 10446814 10.1097/00003246-199907000-00002
    • Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27(7):1230-1251
    • (1999) Crit Care Med , vol.27 , Issue.7 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3    Tinsley, K.W.4    Cobb, J.P.5    Matuschak, G.M.6
  • 16
    • 33745316012 scopus 로고    scopus 로고
    • Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis
    • 1:CAS:528:DC%2BD28XlvV2ntbs%3D 16785553
    • Schwulst SJ, Grayson MH, DiPasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA et al (2006) Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 177(1):557-565
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 557-565
    • Schwulst, S.J.1    Grayson, M.H.2    Dipasco, P.J.3    Davis, C.G.4    Brahmbhatt, T.S.5    Ferguson, T.A.6
  • 17
    • 61449142534 scopus 로고    scopus 로고
    • Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury
    • 1:CAS:528:DC%2BD1MXivVarsbg%3D 19088177 10.1189/jlb.0808491
    • Unsinger J, Kazama H, McDonough JS, Hotchkiss RS, Ferguson TA (2009) Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. J Leukoc Biol 85(3):382-390
    • (2009) J Leukoc Biol , vol.85 , Issue.3 , pp. 382-390
    • Unsinger, J.1    Kazama, H.2    McDonough, J.S.3    Hotchkiss, R.S.4    Ferguson, T.A.5
  • 18
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • 1:STN:280:DyaK383ovFeiuw%3D%3D 1303622 10.1378/chest.101.6.1644
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101(6):1644-1655
    • (1992) Chest , vol.101 , Issue.6 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6
  • 19
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • 1:CAS:528:DC%2BD1MXltFShtA%3D%3D 19147574 10.1158/0008-5472.CAN-08-2361
    • Wieczorek G, Asemissen A, Model F, Turbachova I, Floess S, Liebenberg V et al (2009) Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res 69(2):599-608
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3    Turbachova, I.4    Floess, S.5    Liebenberg, V.6
  • 20
    • 0037144612 scopus 로고    scopus 로고
    • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    • 1:CAS:528:DC%2BD38Xnt1ansLg%3D 12242444 10.1126/science.1072615
    • Bourgeois C, Rocha B, Tanchot C (2002) A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297(5589):2060-2063
    • (2002) Science , vol.297 , Issue.5589 , pp. 2060-2063
    • Bourgeois, C.1    Rocha, B.2    Tanchot, C.3
  • 21
    • 84861667506 scopus 로고    scopus 로고
    • Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis
    • 1:CAS:528:DC%2BC38XosVeksro%3D 22693573 10.1371/journal.pone.0037393
    • Brunialti MK, Santos MC, Rigato O, Machado FR, Silva E, Salomao R (2012) Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis. PLoS One 7(5):e37393
    • (2012) PLoS One , vol.7 , Issue.5 , pp. 37393
    • Brunialti, M.K.1    Santos, M.C.2    Rigato, O.3    Machado, F.R.4    Silva, E.5    Salomao, R.6
  • 22
    • 77954406277 scopus 로고    scopus 로고
    • Lymphocyte and monocyte flow cytometry immunophenotyping as a diagnostic tool in uncharacteristic inflammatory disorders
    • 2912311 20626864 10.1186/1471-2334-10-205
    • Janols H, Bredberg A, Thuvesson I, Janciauskiene S, Grip O, Wullt M (2010) Lymphocyte and monocyte flow cytometry immunophenotyping as a diagnostic tool in uncharacteristic inflammatory disorders. BMC Infect Dis 10:205
    • (2010) BMC Infect Dis , vol.10 , pp. 205
    • Janols, H.1    Bredberg, A.2    Thuvesson, I.3    Janciauskiene, S.4    Grip, O.5    Wullt, M.6
  • 23
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • 1:CAS:528:DC%2BC38XjsV2ms7g%3D 3287223 22378047 10.1172/JCI59643
    • Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122(3):787-795
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 24
    • 83555168313 scopus 로고    scopus 로고
    • An alternate perspective on the roles of TIMPs and MMPs in pathology
    • 1:CAS:528:DC%2BC38Xhs1Oqt7s%3D 22033229 10.1016/j.ajpath.2011.09.008
    • Moore CS, Crocker SJ (2012) An alternate perspective on the roles of TIMPs and MMPs in pathology. Am J Pathol 180(1):12-16
    • (2012) Am J Pathol , vol.180 , Issue.1 , pp. 12-16
    • Moore, C.S.1    Crocker, S.J.2
  • 25
    • 84856387609 scopus 로고    scopus 로고
    • Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
    • 1:CAS:528:DC%2BC38XislWks7g%3D 3268270 22233810 10.1073/pnas.1115761109
    • Barreiro LB, Tailleux L, Pai AA, Gicquel B, Marioni JC, Gilad Y (2012) Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 109(4):1204-1209
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.4 , pp. 1204-1209
    • Barreiro, L.B.1    Tailleux, L.2    Pai, A.A.3    Gicquel, B.4    Marioni, J.C.5    Gilad, Y.6
  • 26
    • 0027326831 scopus 로고
    • Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression
    • 1:STN:280:DyaK3szntlOmtg%3D%3D 7689946 10.1378/chest.104.3.847
    • Lin RY, Astiz ME, Saxon JC, Rackow EC (1993) Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression. Chest 104(3):847-853
    • (1993) Chest , vol.104 , Issue.3 , pp. 847-853
    • Lin, R.Y.1    Astiz, M.E.2    Saxon, J.C.3    Rackow, E.C.4
  • 27
    • 84867328555 scopus 로고    scopus 로고
    • Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome
    • 22885911 10.1016/j.jinf.2012.08.001
    • Xu PB, Lou JS, Ren Y, Miao CH, Deng XM (2012) Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome. J Infect 65(5):380-391
    • (2012) J Infect , vol.65 , Issue.5 , pp. 380-391
    • Xu, P.B.1    Lou, J.S.2    Ren, Y.3    Miao, C.H.4    Deng, X.M.5
  • 28
    • 33646813341 scopus 로고    scopus 로고
    • TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock
    • 1:CAS:528:DC%2BD28Xktlyqsbw%3D 16670636 10.1097/01.shk.0000217815.57727. 29
    • Brunialti MK, Martins PS, Barbosa de Carvalho H, Machado FR, Barbosa LM, Salomao R (2006) TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 25(4):351-357
    • (2006) Shock , vol.25 , Issue.4 , pp. 351-357
    • Brunialti, M.K.1    Martins, P.S.2    Barbosa De Carvalho, H.3    Machado, F.R.4    Barbosa, L.M.5    Salomao, R.6
  • 29
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • 1:CAS:528:DC%2BD1MXht1WntbjO 19781994 10.1016/j.it.2009.07.009 Research Support, Non-U.S. Gov't Review
    • Biswas SK, Lopez-Collazo E (2009) Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 30(10):475-487, Research Support, Non-U.S. Gov't Review
    • (2009) Trends Immunol , vol.30 , Issue.10 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 30
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • 1:STN:280:DC%2BD3Mvgs12gtg%3D%3D 11445675 10.1097/00003246-200107000- 00002
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7):1303-1310
    • (2001) Crit Care Med , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 31
    • 27744600560 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis in elderly patients
    • 1:CAS:528:DC%2BD2MXht1emu7fM 16237654 10.1086/432007
    • Opal SM, Girard TD, Ely EW (2005) The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis 41(Suppl 7):S504-S512
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 7
    • Opal, S.M.1    Girard, T.D.2    Ely, E.W.3
  • 33
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • 1:CAS:528:DC%2BD3cXjslyltbY%3D 10839541 10.1038/35013070
    • Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785):458-462
    • (2000) Nature , vol.405 , Issue.6785 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3    Yang, H.4    Botchkina, G.I.5    Watkins, L.R.6
  • 34
    • 34247847681 scopus 로고    scopus 로고
    • Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    • 1:CAS:528:DC%2BD2sXltlagu7w%3D 17090225 10.1146/annurev.immunol.25. 022106.141647
    • Serhan CN (2007) Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 25:101-137
    • (2007) Annu Rev Immunol , vol.25 , pp. 101-137
    • Serhan, C.N.1
  • 35
    • 84862766869 scopus 로고    scopus 로고
    • A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis
    • 22742734 10.1186/cc11404
    • Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, Green JM (2012) A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care 16(3):R112
    • (2012) Crit Care , vol.16 , Issue.3 , pp. 112
    • Boomer, J.S.1    Shuherk-Shaffer, J.2    Hotchkiss, R.S.3    Green, J.M.4
  • 36
    • 80054121374 scopus 로고    scopus 로고
    • Macrophages in cancer and infectious diseases: The 'good' and the 'bad'
    • 1:CAS:528:DC%2BC3MXhtlWjt7rE 21995571 10.2217/imt.11.116
    • Porta C, Riboldi E, Totaro MG, Strauss L, Sica A, Mantovani A (2011) Macrophages in cancer and infectious diseases: the 'good' and the 'bad'. Immunotherapy 3(10):1185-1202
    • (2011) Immunotherapy , vol.3 , Issue.10 , pp. 1185-1202
    • Porta, C.1    Riboldi, E.2    Totaro, M.G.3    Strauss, L.4    Sica, A.5    Mantovani, A.6
  • 37
    • 84255194001 scopus 로고    scopus 로고
    • Immunosuppression in patients who die of sepsis and multiple organ failure
    • 1:CAS:528:DC%2BC3MXhs1OhtbrF 3361243 22187279 10.1001/jama.2011.1829
    • Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH et al (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306(23):2594-2605
    • (2011) JAMA , vol.306 , Issue.23 , pp. 2594-2605
    • Boomer, J.S.1    To, K.2    Chang, K.C.3    Takasu, O.4    Osborne, D.F.5    Walton, A.H.6
  • 38
    • 0030054966 scopus 로고    scopus 로고
    • Activation antigen expression on human T cells. I. Analysis by two-colour flow cytometry of umbilical cord blood, adult blood and lymphoid tissue
    • 1:STN:280:DyaK283otVOqtA%3D%3D 2200463 8697627 10.1046/j.1365-2249.1996. d01-722.x
    • Amlot PL, Tahami F, Chinn D, Rawlings E (1996) Activation antigen expression on human T cells. I. Analysis by two-colour flow cytometry of umbilical cord blood, adult blood and lymphoid tissue. Clin Exp Immunol 105(1):176-182
    • (1996) Clin Exp Immunol , vol.105 , Issue.1 , pp. 176-182
    • Amlot, P.L.1    Tahami, F.2    Chinn, D.3    Rawlings, E.4
  • 39
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: From basic science to medicine
    • 3240141 12110143 10.1186/ar565
    • Naka T, Nishimoto N, Kishimoto T (2002) The paradigm of IL-6: from basic science to medicine. Arthritis Res 4(Suppl 3):S233-S242
    • (2002) Arthritis Res. , vol.4 , Issue.SUPPL. 3
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 40
    • 77956403940 scopus 로고    scopus 로고
    • Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
    • 1:CAS:528:DC%2BC3cXhtVeisb%2FP 20483923 10.1189/jlb.0110037
    • Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS (2010) Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol 88(2):233-240
    • (2010) J Leukoc Biol , vol.88 , Issue.2 , pp. 233-240
    • Brahmamdam, P.1    Inoue, S.2    Unsinger, J.3    Chang, K.C.4    McDunn, J.E.5    Hotchkiss, R.S.6
  • 41
    • 70349469854 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial
    • 1:CAS:528:DC%2BD1MXht12gsLfO 19590022 10.1164/rccm.200903-0363OC
    • Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J et al (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 180(7):640-648
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.7 , pp. 640-648
    • Meisel, C.1    Schefold, J.C.2    Pschowski, R.3    Baumann, T.4    Hetzger, K.5    Gregor, J.6


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