The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: Secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database

Critical Care

Volumn 10, Issue 2, 2006, Pages

  Harrison, David A ^a   Welch, Catherine A ^a   Eddleston, Jane M ^b  

^a and London School of Hygiene Tropical Medicine   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CASE MIX; CLINICAL DATA REPOSITORY; DISEASE SEVERITY; EVIDENCE BASED MEDICINE; HEALTH PROMOTION; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; IRELAND; MEDICAL AUDIT; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SECONDARY ANALYSIS; SEPSIS; STATISTICAL MODEL; TREND STUDY; UNITED KINGDOM; DIAGNOSIS RELATED GROUP; FACTUAL DATABASE; PATHOPHYSIOLOGY;

DATABASES, FACTUAL; DIAGNOSIS-RELATED GROUPS; ENGLAND; HUMANS; INTENSIVE CARE UNITS; NORTHERN IRELAND; SEPSIS; WALES;

EID: 33749027114     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc4854     Document Type: Article

References (31)

1. Bone RC Balk RA Cerra FB Dellinger RP Fein AM Knaus WA Schein RM Sibbald WJ Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 1992 101 1644-1655 1303622
2. Laterre PF Levy H Clermont G Ball DE Garg R Nelson DR Dhainaut JF Angus DC Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial Crit Care Med 2004 32 2207-2218 15640632
3. Abraham E Wunderink R Silverman H Perl TM Nasraway S Levy H Bone R Wenzel RP Balk R Allred R Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group JAMA 1995 273 934-941 10.1001/ jama.273.12.934 7884952
4. Abraham E Laterre PF Garbino J Pingleton S Butler T Dugernier T Margolis B Kudsk K Zimmerli W Anderson P Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients Crit Care Med 2001 29 503-510 10.1097/ 00003246-200103000-00006 11373411
5. Bernard GR Vincent JL Laterre PF LaRosa SP Dhainaut JF Lopez-Rodriguez A Steingrub JS Garber GE Helterbrand JD Ely EW Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001 344 699-709 10.1056/NEJM200103083441001 11236773
6. Ziegler EJ Fisher CJ Jr Sprung CL Straube RC Sadoff JC Foulke GE Wortel CH Fink MP Dellinger RP Teng NN Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group N Engl J Med 1991 324 429-436 1988827
7. Rivers E Nguyen B Havstad S Ressler J Muzzin A Knoblich B Peterson E Tomlanovich M Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med 2001 345 1368-1377 10.1056/ NEJMoa010307 11794169
8. Dellinger RP Carlet JM Masur H Gerlach H Calandra T Cohen J Gea-Banacloche J Keh D Marshall JC Parker MM Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock Crit Care Med 2004 32 858-873 10.1097/01.CCM.0000117317.18092.E4 15090974
9. Levy MM Pronovost PJ Dellinger RP Townsend S Resar RK Clemmer TP Ramsay G Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome Crit Care Med 2004 32 S595-S597 10.1097/ 01.CCM.0000147016.53607.C4 15542969
10. Linde-Zwirble WT Angus DC Severe sepsis epidemiology: Sampling, selection, and society Crit Care 2004 8 222-226 522859 15312201 10.1186/ cc2917
11. Padkin A Rowan K Black N Using high quality clinical databases to complement the results of randomised controlled trials: The case of recombinant human activated protein C BMJ 2001 323 923-926 1121446 11668142 10.1136/bmj.323.7318.923
12. Padkin A Goldfrad C Brady AR Young D Black N Rowan K Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland Crit Care Med 2003 31 2332-2338 10.1097/01.CCM.0000085141.75513.2B 14501964
13. Harrison DA Brady AR Rowan K Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: The Intensive Care National Audit & Research Centre Case Mix Programme Database Crit Care 2004 8 R99- 111 420043 15025784 10.1186/cc2834
14. Knaus WA Draper EA Wagner DP Zimmerman JE APACHE II: A severity of disease classification system Crit Care Med 1985 13 818-829 3928249
15. Harrell FE Jr Robust estimation of the covariance matrix Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis New York: Springer-Verlag 2001 193-194
16. CMA Medical Data Directory of Critical Care Cambridge: CMA Medical Data 2001
17. Efron B Tibshirani RJ An Introduction to the Bootstrap New York: Chapman & Hall 1993
18. National Statistics Online http://www.statistics.gov.uk/
19. Martin GS Mannino DM Eaton S Moss M The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 2003 348 1546-1554 10.1056/NEJMoa022139 12700374
20. Flaatten H Epidemiology of sepsis in Norway in 1999 Crit Care 2004 8 R180-R184 522836 15312216 10.1186/cc2867
21. Dombrovskiy VY Martin AA Sunderram J Paz HL Facing the challenge: decreasing case fatality rates in severe sepsis despite increasing hospitalizations Crit Care Med 2005 33 2555-2562 10.1097/ 01.CCM.0000186748.64438.7B 16276180
22. Zahorec R Firment J Strakova J Mikula J Malik P Novak I Zeman J Chlebo P Epidemiology of severe sepsis in intensive care units in the Slovak Republic Infection 2005 33 122-128 10.1007/s15010-005-4019-2 15940412
23. Brun-Buisson C Doyon F Carlet J Dellamonica P Gouin F Lepoutre A Mercier JC Offenstadt G Regnier B Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis JAMA 1995 274 968-974 7674528 10.1001/jama.274.12.968
24. Alberti C Brun-Buisson C Burchardi H Martin C Goodman S Artigas A Sicignano A Palazzo M Moreno R Boulme R Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study Intensive Care Med 2002 28 108-121 10.1007/s00134-001-1143-z 11907653
25. Silva E Pedro MA Sogayar AC Mohovic T Silva CL Janiszewski M Cal RG de Sousa EF Abe TP de Andrade J Brazilian Sepsis Epidemiological Study (BASES study) Crit Care 2004 8 R251-R260 522852 15312226 10.1186/cc2892
26. van Gestel A Bakker J Veraart CP van Hout BA Prevalence and incidence of severe sepsis in Dutch intensive care units Crit Care 2004 8 R153-R162 522831 15312213 10.1186/cc2858
27. Finfer S Bellomo R Lipman J French C Dobb G Myburgh J Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units Intensive Care Med 2004 30 589-596 10.1007/s00134-004-2157-0 14963646
28. Angus DC Linde-Zwirble WT Lidicker J Clermont G Carcillo J Pinsky MR Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Crit Care Med 2001 29 1303-1310 10.1097/00003246-200107000-00002 11445675
29. Angus DC Sirio CA Clermont G Bion J International comparisons of critical care outcome and resource consumption Crit Care Clin 1997 13 389-407 10.1016/S0749-0704(05)70317-1 9107515
30. Brun-Buisson C Meshaka P Pinton P Vallet B EPISEPSIS: A reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units Intensive Care Med 2004 30 580-588 10.1007/s00134-003-2121-4 14997295
31. Participating units [ICNARC - Intensive Care National Audit & Research Centre] http://www.icnarc.org/audit/cmp/participating-units/