메뉴 건너뛰기




Volumn 11, Issue 1, 2014, Pages 35-44

Metabolic consequences of HIV: Pathogenic insights

Author keywords

AIDS; Antiretroviral therapy (ART); Cardiovascular disease; Chronic medical condition; Diabetes; Frailty; HIV; HIV pathogenesis; Inflammation; Metabolism; Mitochondria; Pathogenesis

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPOLYSACCHARIDE; NITROGEN DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4;

EID: 84896704396     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-013-0191-7     Document Type: Review
Times cited : (30)

References (108)
  • 2
    • 84870512485 scopus 로고    scopus 로고
    • HIV infection and obesity:Where did all the wasting go?
    • This study evaluated 681 patients over a two-year time period. They observed a high rate of overweight/obesity prevalence at ARTinitiation (44%), and a 20% increase in overweight/obesity at two years, with only a modest contribution of ART therapy to weight gain
    • • Tate T, Willig AL, Willig JH, Raper JL, Moneyham L, Kempf MC, et al. HIV infection and obesity:where did all the wasting go? Antivir Ther. 2012;17(7):1281-9. This study evaluated 681 patients over a two-year time period. They observed a high rate of overweight/obesity prevalence at ARTinitiation (44%), and a 20% increase in overweight/obesity at two years, with only a modest contribution of ART therapy to weight gain.
    • (2012) Antivir Ther , vol.17 , Issue.7 , pp. 1281-1289
    • Tate, T.1    Willig, A.L.2    Willig, J.H.3    Raper, J.L.4    Moneyham, L.5    Kempf, M.C.6
  • 4
  • 5
    • 77953478280 scopus 로고    scopus 로고
    • Bone changes and fracture risk in individuals infected with HIV
    • Warriner AH, Mugavero MJ. Bone changes and fracture risk in individuals infected with HIV. Curr Rheumatol Rep. 2010;12(3): 163-9.
    • (2010) Curr Rheumatol Rep , vol.12 , Issue.3 , pp. 163-169
    • Warriner, A.H.1    Mugavero, M.J.2
  • 7
    • 77950361861 scopus 로고    scopus 로고
    • Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART
    • Larchmt
    • Terzian AS, Holman S, Nathwani N, Robison E,Weber K, Young M, et al. Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART. J Womens Health (Larchmt). 2009;18(12):1965-74.
    • (2009) J Womens Health , vol.18 , Issue.12 , pp. 1965-1974
    • Terzian, A.S.1    Holman, S.2    Nathwani, N.3    Robison, E.4    Weber, K.5    Young, M.6
  • 8
    • 78650815729 scopus 로고    scopus 로고
    • Multimorbidity patterns in the elderly: A new approach of disease clustering identifies complex interrelations between chronic conditions
    • Schafer I, von Leitner EC, SchonG,Koller D,HansenH,Kolonko T, et al. Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS ONE. 2010;5(12):e15941.
    • (2010) PLoS ONE , vol.5 , Issue.12
    • Schafer, I.1    Von Leitner, E.C.2    Schon, G.3    Koller, D.4    Hansen, H.5    Kolonko, T.6
  • 9
    • 0037111717 scopus 로고    scopus 로고
    • Prevalence, expenditures, and complications of multiple chronic conditions in the elderly
    • DOI 10.1001/archinte.162.20.2269
    • Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162(20):2269-76. (Pubitemid 35332510)
    • (2002) Archives of Internal Medicine , vol.162 , Issue.20 , pp. 2269-2276
    • Wolff, J.L.1    Starfield, B.2    Anderson, G.3
  • 10
    • 84873161717 scopus 로고    scopus 로고
    • Multimorbidity patterns in HIV-infected patients: The role of obesity in chronic disease clustering
    • This study investigated multimorbidity among over 1800 HIV-infected participants. They found that obesity was associated with increasing odds of multimorbidity, and that three distinct multimorbidity clusters could be identified using exploratory factor analysis: 1 metabolic, 2 behavioral, and 3 substance use
    • • Kim DJ,Westfall AO, Chamot E,Willig AL, Mugavero MJ, Ritchie C, et al. Multimorbidity patterns in HIV-infected patients: the role of obesity in chronic disease clustering. J Acquir Immune Defic Syndr. 2012;61(5):600-5. This study investigated multimorbidity among over 1800 HIV-infected participants. They found that obesity was associated with increasing odds of multimorbidity, and that three distinct multimorbidity clusters could be identified using exploratory factor analysis: 1) metabolic, 2) behavioral, and 3) substance use.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , Issue.5 , pp. 600-605
    • Kim, D.J.1    Westfall, A.O.2    Chamot, E.3    Willig, A.L.4    Mugavero, M.J.5    Ritchie, C.6
  • 11
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • This case-control study observed that noninfectious comorbidities and polypathology (multimorbidity) occur more often and at a 10-year earlier time frame among HIV-infected patients than in the general population
    • • Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, Garlassi E, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;53(11):1120-6. This case-control study observed that noninfectious comorbidities and polypathology (multimorbidity) occur more often and at a 10-year earlier time frame among HIV-infected patients than in the general population.
    • (2011) Clin Infect Dis off Publ Infect Dis Soc Am , vol.53 , Issue.11 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3    Menozzi, M.4    Carli, F.5    Garlassi, E.6
  • 13
    • 34250671221 scopus 로고    scopus 로고
    • Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease
    • DOI 10.1210/jc.2006-2190
    • Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007;92(7):2506-12. (Pubitemid 47037350)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.7 , pp. 2506-2512
    • Triant, V.A.1    Lee, H.2    Hadigan, C.3    Grinspoon, S.K.4
  • 14
    • 79959748876 scopus 로고    scopus 로고
    • Association between HIV infection, antiretroviral therapy, and risk of acute myocardial infarction: A cohort and nested case-control study using Quebec's public health insurance database
    • Durand M, Sheehy O, Baril JG, Lelorier J, Tremblay CL. Association between HIV infection, antiretroviral therapy, and risk of acute myocardial infarction: a cohort and nested case-control study using Quebec's public health insurance database. J Acquir Immune Defic Syndr. 2011;57(3):245-53.
    • (2011) J Acquir Immune Defic Syndr , vol.57 , Issue.3 , pp. 245-253
    • Durand, M.1    Sheehy, O.2    Baril, J.G.3    Lelorier, J.4    Tremblay, C.L.5
  • 16
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers andmortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, et al. Inflammatory and coagulation biomarkers andmortality in patients with HIV infection. PLoS Med. 2008;5(10):e203.
    • (2008) PLoS Med , vol.5 , Issue.10
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3    De Wit, S.4    Drummond, F.5    Lane, H.C.6
  • 18
    • 84862514297 scopus 로고    scopus 로고
    • 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors
    • Lond This study confirmed carotid artery 18FDG PET-CT imaging as an effective technique to observe differences between HIV-infected adults versus controls in vascular inflammation and early atherosclerosis
    • • Yarasheski KE, Laciny E, Overton ET, Reeds DN, Harrod M, Baldwin S, et al. 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors. J Inflamm (Lond). 2012;9(1):26. This study confirmed carotid artery 18FDG PET-CT imaging as an effective technique to observe differences between HIV-infected adults versus controls in vascular inflammation and early atherosclerosis.
    • (2012) J Inflamm , vol.9 , Issue.1 , pp. 26
    • Yarasheski, K.E.1    Laciny, E.2    Overton, E.T.3    Reeds, D.N.4    Harrod, M.5    Baldwin, S.6
  • 19
    • 84879120130 scopus 로고    scopus 로고
    • Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men
    • This study observed a significantly greater presence of vulnerable plaques - low attenuation plaque and high-risk 3-feature plaque - in HIV-infected patients that may partly explain the high rates of myocardial infarction and sudden cardiac death in this population
    • • Zanni MV, Abbara S, Lo J, Wai B, Hark D, Marmarelis E, et al. Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men. AIDS. 2013;27(8):1263-72. This study observed a significantly greater presence of vulnerable plaques - low attenuation plaque and high-risk 3-feature plaque - in HIV-infected patients that may partly explain the high rates of myocardial infarction and sudden cardiac death in this population.
    • (2013) AIDS , vol.27 , Issue.8 , pp. 1263-1272
    • Zanni, M.V.1    Abbara, S.2    Lo, J.3    Wai, B.4    Hark, D.5    Marmarelis, E.6
  • 21
    • 48449086593 scopus 로고    scopus 로고
    • Endothelial function in human immunodeficiency virusinfected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152 s
    • Torriani FJ, Komarow L, Parker RA, Cotter BR, Currier JS, Dube MP, et al. Endothelial function in human immunodeficiency virusinfected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152 s. J Am Coll Cardiol. 2008;52(7):569-76.
    • (2008) J Am Coll Cardiol , vol.52 , Issue.7 , pp. 569-576
    • Torriani, F.J.1    Komarow, L.2    Parker, R.A.3    Cotter, B.R.4    Currier, J.S.5    Dube, M.P.6
  • 22
    • 59649115215 scopus 로고    scopus 로고
    • Characterization of noncalcified coronary plaques and identification of culprit lesions in patients with acute coronary syndrome by 64-slice computed tomography
    • Kitagawa T, Yamamoto H, Horiguchi J, Ohhashi N, Tadehara F, Shokawa T, et al. Characterization of noncalcified coronary plaques and identification of culprit lesions in patients with acute coronary syndrome by 64-slice computed tomography. JACC Cardiovasc Imaging. 2009;2(2):153-60.
    • (2009) JACC Cardiovasc Imaging , vol.2 , Issue.2 , pp. 153-160
    • Kitagawa, T.1    Yamamoto, H.2    Horiguchi, J.3    Ohhashi, N.4    Tadehara, F.5    Shokawa, T.6
  • 23
    • 70349637021 scopus 로고    scopus 로고
    • 18 F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease
    • Rominger A, Saam T,Wolpers S, Cyran CC, SchmidtM, Foerster S, et al. 18 F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med. 2009;50(10):1611-20.
    • (2009) J Nucl Med , vol.50 , Issue.10 , pp. 1611-1620
    • Rominger, A.1    Saam, T.2    Wolpers, S.3    Cyran, C.C.4    Schmidt, M.5    Foerster, S.6
  • 24
    • 84881480492 scopus 로고    scopus 로고
    • Carotid Intima-Media Thickness Progression in HIV-Infected Adults Occurs Preferentially at the Carotid Bifurcation and Is Predicted by Inflammation
    • Hsue PY, Scherzer R, Hunt PW, Schnell A, Bolger AF, Kalapus SC et al. Carotid Intima-Media Thickness Progression in HIV-Infected Adults Occurs Preferentially at the Carotid Bifurcation and Is Predicted by Inflammation. Journal of the American Heart Association. 2012;1(2):1-12.
    • (2012) Journal of the American Heart Association , vol.1 , Issue.2 , pp. 1-12
    • Hsue, P.Y.1    Scherzer, R.2    Hunt, P.W.3    Schnell, A.4    Bolger, A.F.5    Kalapus, S.C.6
  • 28
    • 48649085310 scopus 로고    scopus 로고
    • Incidence and risk factors for new-onset diabetes in HIV-infected patients: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
    • De Wit S, Sabin CA, Weber R, Worm SW, Reiss P, Cazanave C, et al. Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. Diabetes Care. 2008;31(6):1224-9.
    • (2008) Diabetes Care , vol.31 , Issue.6 , pp. 1224-1229
    • De Wit, S.1    Sabin, C.A.2    Weber, R.3    Worm, S.W.4    Reiss, P.5    Cazanave, C.6
  • 29
    • 0036776455 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
    • DOI 10.1128/JVI.76.19.9724-9734.2002
    • Kino T, Gragerov A, Slobodskaya O, Tsopanomichalou M, Chrousos GP, Pavlakis GN. Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. J Virol. 2002;76(19):9724-34. (Pubitemid 35006513)
    • (2002) Journal of Virology , vol.76 , Issue.19 , pp. 9724-9734
    • Kino, T.1    Gragerov, A.2    Slobodskaya, O.3    Tsopanomichalou, M.4    Chrousos, G.P.5    Pavlakis, G.N.6
  • 30
    • 38749103477 scopus 로고    scopus 로고
    • Human Immunodeficiency Virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor gamma and inhibits adipocyte differentiation: Implications for HIV-associated lipodystrophy
    • DOI 10.1210/me.2007-0124
    • Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, et al. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor gamma and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. Mol Endocrinol. 2008;22(2):234-47. (Pubitemid 351185928)
    • (2008) Molecular Endocrinology , vol.22 , Issue.2 , pp. 234-247
    • Shrivastav, S.1    Kino, T.2    Cunningham, T.3    Ichijo, T.4    Schubert, U.5    Heinklein, P.6    Chrousos, G.P.7    Kopp, J.B.8
  • 31
    • 0036182863 scopus 로고    scopus 로고
    • Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution
    • DOI 10.1053/meta.2002.29999
    • Meininger G, Hadigan C, Laposata M, Brown J, Rabe J, Louca J, et al. Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution. Metab Clin Exp. 2002;51(2):260-6. (Pubitemid 34168243)
    • (2002) Metabolism: Clinical and Experimental , vol.51 , Issue.2 , pp. 260-266
    • Meininger, G.1    Hadigan, C.2    Laposata, M.3    Brown, J.4    Rabe, J.5    Louca, J.6    Aliabadi, N.7    Grinspoon, S.8
  • 34
    • 84867741203 scopus 로고    scopus 로고
    • HIV infection and glycemic response to newly initiated diabetic medical therapy
    • Han JH, Crane HM, Bellamy SL, Frank I, Cardillo S, Bisson GP, et al. HIV infection and glycemic response to newly initiated diabetic medical therapy. AIDS. 2012;26(16):2087-95.
    • (2012) AIDS , vol.26 , Issue.16 , pp. 2087-2095
    • Han, J.H.1    Crane, H.M.2    Bellamy, S.L.3    Frank, I.4    Cardillo, S.5    Bisson, G.P.6
  • 35
    • 79951716000 scopus 로고    scopus 로고
    • Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy
    • This retrospective study identified a relationship between diabetes risk and sTNFR1, sTNFR2 and hs-CRP among HIV-infected patients with and without a diabetes diagnosis
    • • Brown TT, Tassiopoulos K, Bosch RJ, Shikuma C, McComsey GA. Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy. Diabetes Care. 2010;33(10):2244-9. This retrospective study identified a relationship between diabetes risk and sTNFR1, sTNFR2 and hs-CRP among HIV-infected patients with and without a diabetes diagnosis.
    • (2010) Diabetes Care , vol.33 , Issue.10 , pp. 2244-2249
    • Brown, T.T.1    Tassiopoulos, K.2    Bosch, R.J.3    Shikuma, C.4    McComsey, G.A.5
  • 36
    • 84855348340 scopus 로고    scopus 로고
    • Incidence of low and high-energy fractures in persons with and without HIV infection: A Danish population-based cohort study
    • Hansen AB, Gerstoft J, Kronborg G, Larsen CS, Pedersen C, Pedersen G, et al. Incidence of low and high-energy fractures in persons with and without HIV infection: a Danish population-based cohort study. AIDS. 2012;26(3):285-93.
    • (2012) AIDS , vol.26 , Issue.3 , pp. 285-293
    • Hansen, A.B.1    Gerstoft, J.2    Kronborg, G.3    Larsen, C.S.4    Pedersen, C.5    Pedersen, G.6
  • 39
    • 84896696602 scopus 로고    scopus 로고
    • Lower peak bone mass and abnormal trabecular and cortical microarchitecture in young men infected with HIV early in life
    • Sep 25. [Epub ahead of print]
    • • YinMT, Lund E, Shah J, Zhang CA, Foca M, Neu N et al. Lower peak bone mass and abnormal trabecular and cortical microarchitecture in young men infected with HIV early in life. Aids. 2013 Sep 25. [Epub ahead of print].
    • (2013) Aids
    • YinM, T.1    Lund, E.2    Shah, J.3    Zhang, C.A.4    Foca, M.5    Neu, N.6
  • 41
    • 84887987230 scopus 로고    scopus 로고
    • Low Baseline CD4+ Count Is Associated With Greater Bone Mineral Density Loss After Antiretroviral Therapy Initiation
    • Grant PM, Kitch D, McComsey GA, Dube MP, Haubrich R, Huang J, et al. Low Baseline CD4+ Count Is Associated With Greater Bone Mineral Density Loss After Antiretroviral Therapy Initiation. Clin Infect Dis Off Publ Infect Dis Soc Am. 2013;57(10):1483-8.
    • (2013) Clin Infect Dis off Publ Infect Dis Soc Am , vol.57 , Issue.10 , pp. 1483-1488
    • Grant, P.M.1    Kitch, D.2    McComsey, G.A.3    Dube, M.P.4    Haubrich, R.5    Huang, J.6
  • 43
    • 84888133781 scopus 로고    scopus 로고
    • HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: Beneficial effect of pravastatin
    • doi: 10.1111/acel.12119
    • • Hernandez-Vallejo SJ, Beaupere C, Larghero J, Capeau J, Lagathu C. HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin. Aging Cell. 2013. doi: 10.1111/acel.12119.
    • (2013) Aging Cell
    • Hernandez-Vallejo, S.J.1    Beaupere, C.2    Larghero, J.3    Capeau, J.4    Lagathu, C.5
  • 45
  • 46
    • 84949929686 scopus 로고    scopus 로고
    • Frailty in older inpatients: What physicians need to know
    • McMillan GJ, Hubbard RE. Frailty in older inpatients: what physicians need to know. QJM Mon J Assoc Phys. 2012;105(11):1059-65.
    • (2012) QJM Mon J Assoc Phys , vol.105 , Issue.11 , pp. 1059-1065
    • McMillan, G.J.1    Hubbard, R.E.2
  • 48
    • 84879354628 scopus 로고    scopus 로고
    • Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy
    • This study found that functional impairment following ART initiation is associated with higher CD8+ t-cell activation and higher IL-6 levels
    • • Erlandson KM, Allshouse AA, Jankowski CM, Lee EJ, Rufner KM, Palmer BE, et al. Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy. J Infect Dis. 2013;208(2):249-59. This study found that functional impairment following ART initiation is associated with higher CD8+ t-cell activation and higher IL-6 levels.
    • (2013) J Infect Dis , vol.208 , Issue.2 , pp. 249-259
    • Erlandson, K.M.1    Allshouse, A.A.2    Jankowski, C.M.3    Lee, E.J.4    Rufner, K.M.5    Palmer, B.E.6
  • 49
    • 80855132759 scopus 로고    scopus 로고
    • Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata
    • This study showed that, among patients with CD4+ t-cell counts > 350 cells/mul, uncontrolled viral replication was associated with increased incidence of AIDS
    • • Reekie J, Gatell JM, Yust I, Bakowska E, Rakhmanova A, Losso M, et al. Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata. AIDS. 2011;25(18):2259-68. This study showed that, among patients with CD4+ t-cell counts > 350 cells/mul, uncontrolled viral replication was associated with increased incidence of AIDS.
    • (2011) AIDS , vol.25 , Issue.18 , pp. 2259-2268
    • Reekie, J.1    Gatell, J.M.2    Yust, I.3    Bakowska, E.4    Rakhmanova, A.5    Losso, M.6
  • 50
    • 84864131448 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2012 Recommendations of the International Antiviral Society-USA panel
    • Thompson MA, Aberg JA, Hoy JF, Telenti A, Benson C, Cahn P, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA J Am Med Assoc. 2012;308(4):387-402.
    • (2012) JAMA J Am Med Assoc , vol.308 , Issue.4 , pp. 387-402
    • Thompson, M.A.1    Aberg, J.A.2    Hoy, J.F.3    Telenti, A.4    Benson, C.5    Cahn, P.6
  • 53
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Investig. 2013;123(3):966-72.
    • (2013) J Clin Investig , vol.123 , Issue.3 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 56
    • 38949174996 scopus 로고    scopus 로고
    • + T Cell Memory
    • DOI 10.1016/j.immuni.2007.12.016, PII S1074761308000368
    • Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity. 2008;28(2):258-70. (Pubitemid 351222655)
    • (2008) Immunity , vol.28 , Issue.2 , pp. 258-270
    • Scholer, A.1    Hugues, S.2    Boissonnas, A.3    Fetler, L.4    Amigorena, S.5
  • 58
    • 78149471644 scopus 로고    scopus 로고
    • Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals
    • Gordon SN, Cervasi B, Odorizzi P, Silverman R, Aberra F, Ginsberg G, et al. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. J Immunol. 2010;185(9):5169-79.
    • (2010) J Immunol , vol.185 , Issue.9 , pp. 5169-5179
    • Gordon, S.N.1    Cervasi, B.2    Odorizzi, P.3    Silverman, R.4    Aberra, F.5    Ginsberg, G.6
  • 60
    • 80052882129 scopus 로고    scopus 로고
    • Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    • Lederman MM, Calabrese L, Funderburg NT, Clagett B, Medvik K, Bonilla H, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011;204(8):1217-26.
    • (2011) J Infect Dis , vol.204 , Issue.8 , pp. 1217-1226
    • Lederman, M.M.1    Calabrese, L.2    Funderburg, N.T.3    Clagett, B.4    Medvik, K.5    Bonilla, H.6
  • 62
    • 80051552856 scopus 로고    scopus 로고
    • Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation
    • Ellis CL, Ma ZM, Mann SK, Li CS, Wu J, Knight TH, et al. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr. 2011;57(5):363-70.
    • (2011) J Acquir Immune Defic Syndr , vol.57 , Issue.5 , pp. 363-370
    • Ellis, C.L.1    Ma, Z.M.2    Mann, S.K.3    Li, C.S.4    Wu, J.5    Knight, T.H.6
  • 65
    • 78650623431 scopus 로고    scopus 로고
    • Reverse cholesterol transport: From classical view to new insights
    • van der Velde AE. Reverse cholesterol transport: from classical view to new insights. World J Gastroenterol WJG. 2010;16(47): 5908-15.
    • (2010) World J Gastroenterol WJG , vol.16 , Issue.47 , pp. 5908-5915
    • Van Der Velde, A.E.1
  • 66
    • 84863346611 scopus 로고    scopus 로고
    • HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction
    • Huang CY, Chiang SF, Lin TY, Chiou SH, Chow KC. HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction. PLoS ONE. 2012;7(3):e33657.
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Huang, C.Y.1    Chiang, S.F.2    Lin, T.Y.3    Chiou, S.H.4    Chow, K.C.5
  • 67
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce EL, Poffenberger MC, Chang CH, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science. 2013;342(6155): 1242454.
    • (2013) Science. , vol.342 , Issue.6155 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 68
    • 0038030965 scopus 로고    scopus 로고
    • Clinical review 159 - Human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: Clinical presentation, pathophysiology, and therapeutic strategies
    • DOI 10.1210/jc.2002-021704
    • LeowMK, Addy CL,Mantzoros CS. Clinical review 159: Human immunodeficiency virus/highly active antiretroviral therapyassociated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab. 2003;88(5):1961-76. (Pubitemid 36549862)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.5 , pp. 1961-1976
    • Leow, M.K.S.1    Addy, C.L.2    Mantzoros, C.S.3
  • 70
    • 77954348815 scopus 로고    scopus 로고
    • Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy
    • Grunfeld C, Saag M, Cofrancesco Jr J, Lewis CE, Kronmal R, Heymsfield S, et al. Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy. AIDS. 2010;24(11): 1717-26.
    • (2010) AIDS , vol.24 , Issue.11 , pp. 1717-1726
    • Grunfeld, C.1    Saag, M.2    Cofrancesco Jr., J.3    Lewis, C.E.4    Kronmal, R.5    Heymsfield, S.6
  • 71
    • 84885025949 scopus 로고    scopus 로고
    • Adipose Tissue and Immune Function: A Review of Evidence Relevant to HIV Infection
    • Koethe JR, Hulgan T, Niswender K. Adipose Tissue and Immune Function: A Review of Evidence Relevant to HIV Infection. J Infect Dis. 2013;208(8):1194- 201.
    • (2013) J Infect Dis , vol.208 , Issue.8 , pp. 1194-1201
    • Koethe, J.R.1    Hulgan, T.2    Niswender, K.3
  • 72
    • 0026547557 scopus 로고
    • Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome
    • Grunfeld C, Pang M, Shimizu L, Shigenaga JK, Jensen P, Feingold KR. Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Am J Clin Nutr. 1992;55(2):455-60.
    • (1992) Am J Clin Nutr , vol.55 , Issue.2 , pp. 455-460
    • Grunfeld, C.1    Pang, M.2    Shimizu, L.3    Shigenaga, J.K.4    Jensen, P.5    Feingold, K.R.6
  • 74
    • 84880700464 scopus 로고    scopus 로고
    • Effects of HIV and antiretroviral therapy on resting energy expenditure in adult HIV-infected women - A matched, prospective, cross-sectional study
    • Mittelsteadt AL, Hileman CO, Harris SR, Payne KM, Gripshover BM,McComsey GA. Effects of HIV and antiretroviral therapy on resting energy expenditure in adult HIV-infected women-a matched, prospective, cross-sectional study. J Acad Nutr Diet. 2013;113(8):1037-43.
    • (2013) J Acad Nutr Diet , vol.113 , Issue.8 , pp. 1037-1043
    • Mittelsteadt, A.L.1    Hileman, C.O.2    Harris, S.R.3    Payne, K.M.4    Gripshover, B.M.5    McComsey, G.A.6
  • 75
    • 80053254343 scopus 로고    scopus 로고
    • Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy expenditure
    • Kosmiski LA, Sage-El A, Kealey EH, Bessesen DH. Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy expenditure. Obesity. 2011;19(10): 2096-8.
    • (2011) Obesity , vol.19 , Issue.10 , pp. 2096-2098
    • Kosmiski, L.A.1    Sage-El, A.2    Kealey, E.H.3    Bessesen, D.H.4
  • 76
    • 77956572407 scopus 로고    scopus 로고
    • Smoking among HIV positive New Yorkers: Prevalence, frequency, and opportunities for cessation
    • Tesoriero JM, Gieryic SM, Carrascal A, Lavigne HE. Smoking among HIV positive New Yorkers: prevalence, frequency, and opportunities for cessation. AIDS Behav. 2010;14(4):824-35.
    • (2010) AIDS Behav , vol.14 , Issue.4 , pp. 824-835
    • Tesoriero, J.M.1    Gieryic, S.M.2    Carrascal, A.3    Lavigne, H.E.4
  • 77
    • 84876067193 scopus 로고    scopus 로고
    • Vital signs: Current cigarette smoking among sdults aged > 18 years with mental illnes - United States, 2990-2011
    • (CDC) CfDCaP
    • (CDC) CfDCaP. Vital signs: current cigarette smoking among sdults aged > 18 years with mental illnes - United States, 2990-2011. Morb Mortal Wkly Rep. 2013;62(5):81-7.
    • (2013) Morb Mortal Wkly Rep , vol.62 , Issue.5 , pp. 81-87
  • 80
    • 77954657764 scopus 로고    scopus 로고
    • Health and treatment implications of food insufficiency among people living with HIV/AIDS, Atlanta, Georgia
    • Kalichman SC, Cherry C, Amaral C, White D, Kalichman MO, Pope H, et al. Health and treatment implications of food insufficiency among people living with HIV/AIDS, Atlanta, Georgia. J Urban Health. 2010;87(4):631-41.
    • (2010) J Urban Health , vol.87 , Issue.4 , pp. 631-641
    • Kalichman, S.C.1    Cherry, C.2    Amaral, C.3    White, D.4    Kalichman, M.O.5    Pope, H.6
  • 81
    • 70349664169 scopus 로고    scopus 로고
    • Food insecurity among homeless and marginally housed individuals living with HIV/AIDS in San Francisco
    • Weiser SD, Bangsberg DR, Kegeles S, Ragland K, Kushel MB, Frongillo EA. Food insecurity among homeless and marginally housed individuals living with HIV/AIDS in San Francisco. AIDS Behav. 2009;13(5):841-8.
    • (2009) AIDS Behav , vol.13 , Issue.5 , pp. 841-848
    • Weiser, S.D.1    Bangsberg, D.R.2    Kegeles, S.3    Ragland, K.4    Kushel, M.B.5    Frongillo, E.A.6
  • 84
    • 84862163853 scopus 로고    scopus 로고
    • The effects of dietary intervention on HIV dyslipidaemia: A systematic review and meta-analysis
    • Stradling C, Chen YF, Russell T, ConnockM, Thomas GN, Taheri S. The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. PLoS ONE. 2012;7(6): e38121.
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Stradling, C.1    Chen, Y.F.2    Russell, T.3    Connock, M.4    Thomas, G.N.5    Taheri, S.6
  • 85
    • 84884969345 scopus 로고    scopus 로고
    • Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet
    • Viskovic K, Rutherford GW, Sudario G, Stemberger L, Brnic Z, Begovac J. Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet. Croat Med J. 2013;54(4):330-8.
    • (2013) Croat Med J , vol.54 , Issue.4 , pp. 330-338
    • Viskovic, K.1    Rutherford, G.W.2    Sudario, G.3    Stemberger, L.4    Brnic, Z.5    Begovac, J.6
  • 88
    • 3042654996 scopus 로고    scopus 로고
    • Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences
    • DOI 10.1161/01.CIR.0000130640.77501.79
    • Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Gallimore JR, et al. Obesity is an important determinant of baseline serumC-reactive protein concentration inmonozygotic twins, independent of genetic influences. Circulation. 2004;109(24): 3022-8. (Pubitemid 38808325)
    • (2004) Circulation , vol.109 , Issue.24 , pp. 3022-3028
    • Greenfield, J.R.1    Samaras, K.2    Jenkins, A.B.3    Kelly, P.J.4    Spector, T.D.5    Gallimore, J.R.6    Pepys, M.B.7    Campbell, L.V.8
  • 90
    • 80054059676 scopus 로고    scopus 로고
    • An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy
    • Koethe JR, Jenkins CA, Shepherd BE, Stinnette SE, Sterling TR. An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;53(9):952-60.
    • (2011) Clin Infect Dis off Publ Infect Dis Soc Am , vol.53 , Issue.9 , pp. 952-960
    • Koethe, J.R.1    Jenkins, C.A.2    Shepherd, B.E.3    Stinnette, S.E.4    Sterling, T.R.5
  • 92
    • 84884699100 scopus 로고    scopus 로고
    • Body Mass Index, Immune Status, and Virological Control in HIV-Infected Men Who Have Sex with Men
    • Blashill AJ, Mayer KH, Crane HM, Grasso C, Safren SA. Body Mass Index, Immune Status, and Virological Control in HIV-Infected Men Who Have Sex with Men. J Int Assoc Providers AIDS Care. 2013;12(5):319-24.
    • (2013) J Int Assoc Providers AIDS Care , vol.12 , Issue.5 , pp. 319-324
    • Blashill, A.J.1    Mayer, K.H.2    Crane, H.M.3    Grasso, C.4    Safren, S.A.5
  • 93
    • 33748491023 scopus 로고    scopus 로고
    • Body composition and metabolic effects of a diet and exercise weight loss regimen on obese, HIV-infected women
    • DOI 10.1016/j.metabol.2006.05.018, PII S0026049506001855
    • Engelson ES, Agin D, Kenya S,Werber-Zion G, Luty B, Albu JB, et al. Body composition and metabolic effects of a diet and exercise weight loss regimen on obese, HIV-infected women. Metab Clin Exp. 2006;55(10):1327-36. (Pubitemid 44354946)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.10 , pp. 1327-1336
    • Engelson, E.S.1    Agin, D.2    Kenya, S.3    Werber-Zion, G.4    Luty, B.5    Albu, J.B.6    Kotler, D.P.7
  • 98
    • 0035882187 scopus 로고    scopus 로고
    • Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis
    • DOI 10.1086/321909
    • Graham CS, Baden LR, Yu E,Mrus JM, Carnie J, Heeren T, et al. Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis. Clin Inf Dis Off Publ Infect Dis Soc Am. 2001;33(4):562-9. (Pubitemid 32709592)
    • (2001) Clinical Infectious Diseases , vol.33 , Issue.4 , pp. 562-569
    • Graham, C.S.1    Baden, L.R.2    Yu, E.3    Mrus, J.M.4    Carnie, J.5    Heeren, T.6    Koziel, M.J.7
  • 99
    • 80052775236 scopus 로고    scopus 로고
    • Alcohol use among patients with HIV infection
    • BonaciniM. Alcohol use among patients with HIV infection. Ann Hepatol. 2011;10(4):502-7.
    • (2011) Ann Hepatol , vol.10 , Issue.4 , pp. 502-507
    • Bonacini, M.1
  • 100
    • 61349155565 scopus 로고    scopus 로고
    • Hazardous drinking is associated with an elevated aspartate aminotransferase to platelet ratio index in an urban HIV-infected clinical cohort
    • Chaudhry AA, SulkowskiMS, Chander G,Moore RD. Hazardous drinking is associated with an elevated aspartate aminotransferase to platelet ratio index in an urban HIV-infected clinical cohort. HIV Med. 2009;10(3):133-42.
    • (2009) HIV Med , vol.10 , Issue.3 , pp. 133-142
    • Chaudhry, A.A.1    Sulkowski, M.S.2    Chander, G.3    Moore, R.D.4
  • 102
    • 79953285141 scopus 로고    scopus 로고
    • Increasing burden of liver disease in patients with HIV infection
    • Joshi D, O'Grady J, Dieterich D, Gazzard B, Agarwal K. Increasing burden of liver disease in patients with HIV infection. Lancet. 2011;377(9772):1198- 209.
    • (2011) Lancet , vol.377 , Issue.9772 , pp. 1198-1209
    • Joshi, D.1    O'Grady, J.2    Dieterich, D.3    Gazzard, B.4    Agarwal, K.5
  • 104
    • 84861538069 scopus 로고    scopus 로고
    • HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue
    • Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, et al. HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis. 2012;205(12):1778-87.
    • (2012) J Infect Dis , vol.205 , Issue.12 , pp. 1778-1787
    • Morse, C.G.1    Voss, J.G.2    Rakocevic, G.3    McLaughlin, M.4    Vinton, C.L.5    Huber, C.6
  • 105
    • 80053614206 scopus 로고    scopus 로고
    • Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response
    • Bhargava A, Raghuram GV, Pathak N, Varshney S, Jatawa SK, Jain D, et al. Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response. Free Radic Biol Med. 2011;51(9):1806-14.
    • (2011) Free Radic Biol Med , vol.51 , Issue.9 , pp. 1806-1814
    • Bhargava, A.1    Raghuram, G.V.2    Pathak, N.3    Varshney, S.4    Jatawa, S.K.5    Jain, D.6
  • 106
    • 79952553684 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in patients with HIV-HCV co-infection as compared to patients with HCV mono-infection
    • This study showed that HCV infection is independently associated with liver mitochondrial dysfunction in HIV-infected patients
    • • Chapplain JM, Tattevin P, Guyader D, Begue JM, Beillot J, Turlin B, et al. Mitochondrial abnormalities in patients with HIV-HCV co-infection as compared to patients with HCV mono-infection. HIV Clin Trials. 2011;12(1):54-60. This study showed that HCV infection is independently associated with liver mitochondrial dysfunction in HIV-infected patients.
    • (2011) HIV Clin Trials , vol.12 , Issue.1 , pp. 54-60
    • Chapplain, J.M.1    Tattevin, P.2    Guyader, D.3    Begue, J.M.4    Beillot, J.5    Turlin, B.6
  • 107
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • DOI 10.1146/annurev.genet.39.110304.095751
    • Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005;39:359-407. (Pubitemid 43011120)
    • (2005) Annual Review of Genetics , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 108
    • 84887290531 scopus 로고    scopus 로고
    • Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers
    • This study showed that HIV replication continues in elite controllers with low levels of plasma HIV RNA, and that this subset of patients may benefit from initiation of ART to control chronic, systemic inflammation
    • • Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, et al. Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers. PLoS Pathog. 2013;9(10):e1003691. This study showed that HIV replication continues in elite controllers with low levels of plasma HIV RNA, and that this subset of patients may benefit from initiation of ART to control chronic, systemic inflammation.
    • (2013) PLoS Pathog , vol.9 , Issue.10
    • Hatano, H.1    Yukl, S.A.2    Ferre, A.L.3    Graf, E.H.4    Somsouk, M.5    Sinclair, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.