CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 3, 2014, Pages 502-513

  Kabadi, Shruti V ^a   Stoica, Bogdan A ^a   Loane, David J ^a   Luo, Tao ^a   Faden, Alan I ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

cell cycle; CR8; cyclin dependent kinases; neurodegeneration; neuroinflammation; traumatic brain injury

Indexed keywords

BROXURIDINE; CR 8; CR8; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN G1; CYCLINE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CELL ACTIVATION; CELL CYCLE ACTIVATION; CELL CYCLE S PHASE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; HIPPOCAMPUS; INJURY; LATERAL FLUID PERCUSSION INJURY; MALE; MICROGLIA; MICROGLIAL ACTIVATION; NERVE CELL; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINOBLASTOMA; TRAUMATIC BRAIN INJURY;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; BRAIN INJURIES; CELL CYCLE; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; MALE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PURINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84896703516     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.228     Document Type: Article

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