CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia

European Archives of Psychiatry and Clinical Neuroscience

Volumn 264, Issue 2, 2014, Pages 93-102

  Wolf, Claudia ^a   Mohr, Holger ^a,b   Schneider Axmann, Thomas ^a,c   Reif, Andreas ^e   Wobrock, Thomas ^a   Scherk, Harald ^f   Kraft, Susanne ^d   Schmitt, Andrea ^c   Falkai, Peter ^c   Gruber, Oliver ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f Department of Neurology   (Germany)

Author keywords

Amygdala volume; Bipolar disorder; CACNA1C; Genetic imaging; Obsessive compulsive disorder; Schizophrenia

Indexed keywords

LITHIUM ACETATE;

AMYGDALA VOLUME; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BRAIN SIZE; CACNA1C GENE; CALCIUM SIGNALING; CONTROLLED STUDY; DSM-IV; FOLLOW UP; GENE; GENOTYPE; GRAY MATTER; HANDEDNESS; HEMISPHERE; HUMAN; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MONTGOMERY ASBERG DEPRESSION RATING SCALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OBSESSIVE COMPULSIVE DISORDER; PATHOLOGY; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; RIGHT HEMISPHERE; SCHIZOPHRENIA; SEX DIFFERENCE; YALE BROWN OBSESSIVE COMPULSIVE SCALE;

ADULT; AMYGDALA; ANALYSIS OF VARIANCE; CALCIUM CHANNELS; FEMALE; FUNCTIONAL LATERALITY; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INDIVIDUALITY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOOD DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 84896700609     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-013-0427-y     Document Type: Article

References (56)

1. Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM (2009) Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatr 195:194-201
2. Blond BN, Fredericks CA, Blumberg HP (2012) Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. Bipolar Disord 14:340-355
3. Honea R, Crow TJ, Passingham D, Mackay CE (2005) Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatr 162:2233-2245
4. Kwon JS, Shin YW, Kim CW, Kim YI, Youn T, Han MH et al (2003) Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex. J Neurol Neurosurg Psychiatr 74:962-964
5. Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008) Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32:525-549
6. Milad MR, Rauch SL (2012) Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn Sci 16:43-51
7. Rotge JY, Guehl D, Dilharreguy B, Tignol J, Bioulac B, Allard M et al (2009) Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol Psychiatr 65:75-83
8. Strakowski SM, Delbello MP, Adler CM (2005) The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatr 10:105-116
9. Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD et al (2012) The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord 14:313-325
10. Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M et al (1999) Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatr 56:913-919
11. Townsend J, Altshuler LL (2012) Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord 14:326-339
12. Yoshida T, McCarley RW, Nakamura M, Lee K, Koo MS, Bouix S et al (2009) A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia. Schizophr Res 113:84-94
13. Jogia J, Ruberto G, Lelli-Chiesa G, Vassos E, Maieru M, Tatarelli R et al (2011) The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder. Mol Psychiatr 16:1070-1071
14. Perrier E, Pompei F, Ruberto G, Vassos E, Collier D, Frangou S (2011) Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder. Eur Psychiatr 26:135-137
15. Wessa M, Linke J, Witt SH, Nieratschker V, Esslinger C, Kirsch P et al (2010) The CACNA1C risk variant for bipolar disorder influences limbic activity. Mol Psychiatr 15:1126-1127
16. Tesli M, Skatun KC, Ousdal OT, Brown AA, Thoresen C, Agartz I et al (2013) CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls. PLoS ONE 8:e56970
17. Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S et al (2010) The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatr 15:1016-1022
18. Nyegaard M, Demontis D, Foldager L, Hedemand A, Flint TJ, Sorensen KM et al (2010) CACNA1C (rs1006737) is associated with schizophrenia. Mol Psychiatr 15:119-121
19. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L et al (2008) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40:1056-1058
20. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K et al (2008) Whole-genome association study of bipolar disorder. Mol Psychiatr 13:558-569
21. Erk S, Meyer-Lindenberg A, Schnell K, Opitz von Boberfeld C, Esslinger C, Kirsch P et al (2010) Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatr 67:803-811
22. Roussos P, Giakoumaki SG, Georgakopoulos A, Robakis NK, Bitsios P (2011) The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disord 13:250-259
23. Strohmaier J, Amelang M, Hothorn LA, Witt SH, Nieratschker V, Gerhard D et al (2013) The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population. Mol Psychiatr 18:607-613
24. Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML (2012) Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord 14:375-410
25. Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ et al (2005) Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat Embryol (Berl) 210:343-352
26. Brierley B, Shaw P, David AS (2002) The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Res Brain Res Rev 39:84-105
27. Pruessner JC, Li LM, Serles W, Pruessner M, Collins DL, Kabani N et al (2000) Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb Cortex 10:433-442
28. Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B et al (2010) Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatr 67:939-945
29. Zhang Q, Shen Q, Xu Z, Chen M, Cheng L, Zhai J et al (2012) The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder. Neuropsychopharmacology 37:677-684
30. Hamshere ML, Walters JT, Smith R, Richards AL, Green E, Grozeva D, et al. (2013) Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatr 18:708-712
31. Bora E, Fornito A, Radua J, Walterfang M, Seal M, Wood SJ et al (2011) Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis. Schizophr Res 127:46-57
32. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E (2008) The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am J Psychiatr 165:1015-1023
33. Kong L, Bachmann S, Thomann PA, Essig M, Schroder J (2012) Neurological soft signs and gray matter changes: a longitudinal analysis in first-episode schizophrenia. Schizophr Res 134:27-32
34. Meisenzahl EM, Koutsouleris N, Bottlender R, Scheuerecker J, Jager M, Teipel SJ et al (2008) Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study. Schizophr Res 104:44-60
35. Vita A, De Peri L, Silenzi C, Dieci M (2006) Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophr Res 82:75-88
36. Watson DR, Anderson JM, Bai F, Barrett SL, McGinnity TM, Mulholland CC et al (2012) A voxel based morphometry study investigating brain structural changes in first episode psychosis. Behav Brain Res 227:91-99
37. Witthaus H, Kaufmann C, Bohner G, Ozgurdal S, Gudlowski Y, Gallinat J et al (2009) Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatr Res 173:163-169
38. Hulshoff Pol HE, Schnack HG, Posthuma D, Mandl RC, Baare WF, van Oel C et al (2006) Genetic contributions to human brain morphology and intelligence. J Neurosci 26:10235-10242
39. Peper JS, Schnack HG, Brouwer RM, Van Baal GC, Pjetri E, Szekely E et al (2009) Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs. Hum Brain Mapp 30:2184-2196
40. 2+ ions. J Biol Chem 280:12474-12485
41. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME (2001) Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 294:333-339
42. Monfils MH, Cowansage KK, LeDoux JE (2007) Brain-derived neurotrophic factor: linking fear learning to memory consolidation. Mol Pharmacol 72:235-237
43. Wolf C, Linden DE (2012) Biological pathways to adaptability-interactions between genome, epigenome, nervous system and environment for adaptive behavior. Genes Brain Behav 11:3-28
44. Langwieser N, Christel CJ, Kleppisch T, Hofmann F, Wotjak CT, Moosmang S (2010) Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels. J Neurosci 30:8367-8375
45. Shinnick-Gallagher P, McKernan MG, Xie J, Zinebi F (2003) L-type voltage-gated calcium channels are involved in the in vivo and in vitro expression of fear conditioning. Ann NY Acad Sci 985:135-149
46. Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M et al (2010) Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatr 68:801-810
47. Mogilnicka E, Czyrak A, Maj J (1987) Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioral despair test; antidepressants facilitate nifedipine action. Eur J Pharmacol 138:413-416
48. 2+ channels. J Clin Invest 113:1430-1439
49. Franke B, Vasquez AA, Veltman JA, Brunner HG, Rijpkema M, Fernandez G (2010) Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals. Biol Psychiatr 68:586-588
50. Soeiro-de-Souza MG, Otaduy MC, Dias CZ, Bio DS, Machado-Vieira R, Moreno RA (2012) The impact of the CACNA1C risk allele on limbic structures and facial emotions recognition in bipolar disorder subjects and healthy controls. J Affect Disord 141:94-101
51. Wang F, McIntosh AM, He Y, Gelernter J, Blumberg HP (2011) The association of genetic variation in CACNA1C with structure and function of a frontotemporal system. Bipolar Disord 13:696-700
52. Giegling I, Genius J, Benninghoff J, Rujescu D (2010) Genetic findings in schizophrenia patients related to alterations in the intracellular Ca-homeostasis. Prog Neuropsychopharmacol Biol Psychiatr 34:1375-1380
53. Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C et al (2010) Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci USA 107:10584-10589
54. Lidow MS (2003) Calcium signaling dysfunction in schizophrenia: a unifying approach. Brain Res Brain Res Rev 43:70-84
55. Rushlow WJ, Seah C, Sutton LP, Bjelica A, Rajakumar N (2009) Antipsychotics affect multiple calcium calmodulin dependent proteins. Neuroscience 161:877-886
56. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D et al (2009) Common variants conferring risk of schizophrenia. Nature 460:744-747