The impact of the CACNA1C risk allele on limbic structures and facial emotions recognition in bipolar disorder subjects and healthy controls

Journal of Affective Disorders

Volumn 141, Issue 1, 2012, Pages 94-101

  Soeiro De Souza, Márcio Gerhardt ^a   Otaduy, Maria Concepción Garcia ^a   Dias, Carolina Zadres ^a   Bio, Danielle S ^a   MacHado Vieira, Rodrigo ^a   Moreno, Ricardo Alberto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bipolar disorder; CACNA1C; Calcium channel; Facial emotions recognition; Social cognition

Indexed keywords

CALCIUM CHANNEL L TYPE; METHIONINE; VALINE; VOLTAGE GATED CALCIUM CHANNEL;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ANGER; ARTICLE; BIPOLAR I DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FACIAL EXPRESSION; FEAR; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPPINESS; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; L TYPE VOLTAGE GATED CALCIUM CHANNEL GENE; LIMBIC SYSTEM; MALE; MORPHOLOGY; PHENOTYPE; PRIORITY JOURNAL; SAMPLE SIZE;

ADULT; ALLELES; BIPOLAR DISORDER; CALCIUM CHANNELS, L-TYPE; EMOTIONS; FACIAL EXPRESSION; FEMALE; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; RISK; YOUNG ADULT;

EID: 84865524813     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.03.014     Document Type: Article

References (50)

1. T. Akimoto Effects of calmodulin and protein kinase C modulators on transient Ca2+ increase and capacitative Ca2+ entry in human platelets: relevant to pathophysiology of bipolar disorder Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 1 2007 136 141 (Pubitemid 44959262)
2. K.C. Bickart Amygdala volume and social network size in humans Nature Neuroscience 14 2 2011 163 164
3. K.L. Bigos Genetic variation in CACNA1C affects brain circuitries related to mental illness Archives of General Psychiatry 67 9 2010 939 945
4. C.-H. Chen Explicit and implicit facial affect recognition in manic and depressed states of bipolar disorder: a functional magnetic resonance imaging study Biological Psychiatry 59 1 2006 31 39 (Pubitemid 43005233)
5. K. Deisseroth Signaling from synapse to nucleus: the logic behind the mechanisms Current Opinion in Neurobiology 13 3 2003 354 365 (Pubitemid 36805579)
6. D.P. Dickstein Neural activation during encoding of emotional faces in pediatric bipolar disorder Bipolar Disorders 9 7 2007 679 692 (Pubitemid 350042402)
7. P.A.T.F.O. DSM-IV Diagnostic and statistical manual of mental disorders: DSM-IV-TR 2000 American Psychiatric Publishing, Inc.
8. P. Ekman, and W.V. Friesen Pictures of facial affect 1976 Consulting Psychologists Press Palo Alto, CA
9. M.A.R. Ferreira Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder Nature Genetics 40 9 2008 1056 1058
10. M.B. First, R.L. Spitzer, and J.B. Williams Structured clinical interview for DSM-IV axis I disorders SCID-I 1996 American Psychiatric Press Washington, DC
11. L.C. Foland Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania Psychiatry Research 162 1 2008 27 37 (Pubitemid 50008260)
12. B. Franke Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals Biological Psychiatry 68 6 2010 586 588
13. M. Hamilton A rating scale for depression Journal of Neurology, Neurosurgery, and Psychiatry 23 1960 56 62
14. C.J. Harmer, L. Grayson, and G.M. Goodwin Enhanced recognition of disgust in bipolar illness Biological Psychiatry 51 4 2002 298 304 (Pubitemid 34214995)
15. J. Jogia The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder Molecular Psychiatry 16 11 2011 1070 1071
16. T. Kato Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder Cell Calcium 44 1 2008 92 102
17. M.J. Kempton Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals The American Journal of Psychiatry 166 12 2009 1413 1414
18. C.G. Kohler Facial emotion perception in depression and bipolar disorder: a quantitative review Psychiatry research 188 3 2011 303 309
19. A. Krug Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals NeuroImage 49 2 2010 1831 1836
20. J. Laitinen, J. Samarut, and E. Hölttä A nontoxic and versatile protein salting-out method for isolation of DNA Biotechniques 17 2 1994 316 322 (Pubitemid 2125267)
21. G. Lelli-Chiesa The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives Psychological Medicine 41 4 2011 779 788
22. A. Lembke, and T.A. Ketter Impaired recognition of facial emotion in mania The American Journal of Psychiatry 159 2 2002 302 304 (Pubitemid 34126910)
23. R. Machado-Vieira The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder Biological Psychiatry 69 4 2011 344 352
24. G.S. Malhi Is a lack of disgust something to fear? A functional magnetic resonance imaging facial emotion recognition study in euthymic bipolar disorder patients Bipolar Disorders 9 4 2007 345 357 (Pubitemid 46865367)
25. E. Perrier Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder European Psychiatry: The Journal of the Association of European Psychiatrists 26 3 2011 135 137
26. A.E. Pinkham Implications for the neural basis of social cognition for the study of schizophrenia The American Journal of Psychiatry 160 5 2003 815 824 (Pubitemid 41079565)
27. Psychiatric GWAS Consortium Bipolar Disorder Working Group et al Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 Nature Genetics 43 10 2011 977 983
28. B.A. Rich Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation Development and Psychopathology 20 2 2008 529 546 (Pubitemid 351584023)
29. C.C. Rocca, E. Heuvel, S.C. Caetano, and B. Lafer Facial emotion recognition in bipolar disorder: a critical review Revista brasileira de psiquiatria (São Paulo, Brazil: 1999) 31 2 2009 171 180
30. P. Roussos The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males Bipolar Disorders 13 3 2011 250 259
31. C. Samamé, D.J. Martino, and S.A. Strejilevich Social cognition in euthymic bipolar disorder: systematic review and meta-analytic approach Acta psychiatrica Scandinavica 125 4 2012 266 280
32. E.M. Seidel Risk or resilience? Empathic abilities in patients with bipolar disorders and their first-degree relatives Journal of Psychiatric Research 46 3 2012 382 388
33. D.V. Sheehan The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 The Journal of Clinical Psychiatry 59 Suppl. 20 1998 22 33 (quiz 34-57) (Pubitemid 29001829)
34. S. Shifman COMT: a common susceptibility gene in bipolar disorder and schizophrenia American Journal of Medical Genetics. Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics 128B 1 2004 61 64 (Pubitemid 38849920)
35. P. Shinnick-Gallagher L-type voltage-gated calcium channels are involved in the in vivo and in vitro expression of fear conditioning Annals of the New York Academy of Sciences 985 2003 135 149 (Pubitemid 36521112)
36. J.B. Silk Social components of fitness in primate groups Science (New York, N.Y.) 317 5843 2007 1347 1351 (Pubitemid 47417447)
37. P. Sklar Whole-genome association study of bipolar disorder Molecular Psychiatry 13 6 2008 558 569 (Pubitemid 351704939)
38. M.G. Soeiro de Souza COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes Journal of Affective Disorders 136 3 2012 370 376
39. N. Sourial-Bassillious Glutamate-mediated calcium signaling: a potential target for lithium action Neuroscience 161 4 2009 1126 1134
40. M. Summers Bipolar I and bipolar II disorder: cognition and emotion processing Psychological Medicine 36 12 2006 1799 1809 (Pubitemid 44824741)
41. M. Thimm Effects of a CACNA1C genotype on attention networks in healthy individuals Psychological Medicine 41 7 2011 1551 1561
42. H.R. Venn Perception of facial expressions of emotion in bipolar disorder Bipolar Disorders 6 4 2004 286 293 (Pubitemid 39077088)
43. F. Wang The association of genetic variation in CACNA1C with structure and function of a frontotemporal system Bipolar Disorders 13 7-8 2011 696 700
44. M. Wessa The CACNA1C risk variant for bipolar disorder influences limbic activity Molecular Psychiatry 15 12 2010 1126 1127
45. A.E. West, E.C. Griffith, and M.E. Greenberg Regulation of transcription factors by neuronal activity Nature Reviews. Neuroscience 3 12 2002 921 931 (Pubitemid 135715879)
46. P.J. Whalen, and E.A. Phelps The Human Amygdala 2009 The Guilford Press
47. J.A. White Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice Learning & Memory (Cold Spring Harbor, N.Y.) 15 1 2008 1 5 (Pubitemid 351171599)
48. G.Y. Wu, K. Deisseroth, and R.W. Tsien Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway Proceedings of the National Academy of Sciences of the United States of America 98 5 2001 2808 2813 (Pubitemid 32209565)
49. R.C. Young A rating scale for mania: reliability, validity and sensitivity The British Journal of Psychiatry: The Journal of Mental Science 133 1978 429 435 (Pubitemid 9006756)
50. Q. Zhang The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 37 3 2012 677 684