The functional neuroanatomy of bipolar disorder: A consensus model

Bipolar Disorders

Volumn 14, Issue 4, 2012, Pages 313-325

  Strakowski, Stephen M ^a   Adler, Caleb M ^a   Almeida, Jorge ^b   Altshuler, Lori L ^c,d   Blumberg, Hilary P ^e   Chang, Kiki D ^f   Delbello, Melissa P ^a   Frangou, Sophia ^g   McIntosh, Andrew ^h   Phillips, Mary L ^b,i   Sussman, Jessika E ^h   Townsend, Jennifer D ^c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Amygdala; Bipolar disorder; Connectivity; Functional magnetic resonance imaging (fMRI); Neuroimaging; Prefrontal cortex

Indexed keywords

AMYGDALOID NUCLEUS; BIPOLAR DISORDER; BRAIN REGION; CONSENSUS; DEVELOPMENTAL DISORDER; DIFFUSION TENSOR IMAGING; DISEASE COURSE; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; NEUROANATOMY; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; WHITE MATTER;

AMYGDALA; BIPOLAR DISORDER; BRAIN MAPPING; EMOTIONS; FUNCTIONAL NEUROIMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, ANATOMIC; NEURAL PATHWAYS; PREFRONTAL CORTEX;

EID: 84861503611     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2012.01022.x     Document Type: Review

References (72)

1. Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord 2012; 14: 326-339.
2. Blond BN, Fredericks CA, Blumberg HP. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. Bipolar Disord 2012; 14: 340-355.
3. Schneider MR, DelBello MP, McNamara RK, Strakowski SM, Adler CM. Neuroprogression in bipolar disorder. Bipolar Disord 2012; 14: 356-374.
4. Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML. Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord 2012; 14: 375-410.
5. Whalley HC, Papmeyer M, Sprooten E, Lawrie SM, Sussman JE, McIntosh AM. Review of functional magnetic resonance imaging studies comparing bipolar disorder and schizophrenia. Bipolar Disord 2012; 14: 411-431.
6. Liu J, Blond BN, van Dyck LI, Spencer L, Wang F, Blumberg HP. Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing. Bipolar Disord 2012; 14: 432-441.
7. Townsend JD, Bookheimer SY, Foland-Ross LC et al. Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task. Bipolar Disord 2012; 14: 442-450.
8. Mourão-Miranda J, Almeida J, Hassel S et al. Pattern recognition analyses of brain activation elicited by happy and neutral faces in unipolar and bipolar depression. Bipolar Disord 2012; 14: 451-460.
9. Jogia J, Dima D, Frangou S. Sex differences in bipolar disorder: a review of neuroimaging findings and new evidence. Bipolar Disord 2012; 14: 461-471.
10. Yamasaki H, LaBar KS, McCarthy G. Dissociable prefrontal brain systems for attention and emotion. PNAS 2002; 99: 11447-11451.
11. Chen YC, Thaler D, Nixon PD, Stern CE, Passingham RE. The functions of the medial premotor cortex II. The timing and selection of learned movements. Exp Brain Res 1995; 102: 461-473.
12. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J Cogn Neurosci 1998; 10: 525-535.
13. Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 2002; 16: 331-348.
14. Chen C-H, Suckling J, Lennox BR, Ooi C, Bullmore ET. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 2011; 13: 1-15.
15. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 1997; 154: 926-933.
16. Phillips ML, Ladouceur CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008; 13: 829.
17. Strakowski SM. Integration and consolidation - a neurophysiological model of bipolar disorder. Strakowski SM ed. The Bipolar BraIntegrating Neuroimaging and Genetics. New York: Oxford University Press, 2012: 253-274.
18. Altshuler L, Bookheimer S, Proenza MA et al. Increased amygdala activation during mania: a functional magnetic resonance imaging study. Am J Psychiatry 2005; 162: 1211-1213.
19. Hariri AR, Bookheimer SY, Mazziotta JC. Modulating emotional responses: effects of a neocortical network on the limbic system. NeuroReport 2000; 11: 43-48.
20. Kalmar JH, Wang F, Chepenik LG et al. Relation between amygdala structure and function in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2009; 48: 636-642.
21. Blumberg HP, Donegan NH, Sanislow CA et al. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacol 2005; 183: 308-313.
22. Almeida JR, Versace A, Hassel S, Kupfer DJ, Phillips ML. Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression. Biol Psychiatry 2010; 67: 414-421.
23. Lawrence NS, Williams AM, Surguladze S et al. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry 2004; 55: 578-587.
24. Rich BA, Vinton DT, Roberson-Nay R et al. Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci USA 2006; 103: 8900-8905.
25. Strakowski SM, Adler CM, Holland SK, Mills N, DelBello MP. A preliminary fMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacol 2004; 29: 1734-1740.
26. Altshuler L, Bookheimer S, Townsend J et al. Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study. Bipolar Disord 2008; 10: 708-717.
27. Altshuler LL, Townsend JD. Functional brain imaging in bipolar disorder. Strakowski SM ed. The Bipolar BraIntegrating Neuroimaging and Genetics. New York: Oxford University Press, 2012: 53-78.
28. Strakowski SM, Eliassen JC, Lamy M et al. Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway. Biol Psychiatry 2011; 69: 381-388.
29. Whalley HC, Sussmann JE, Chakirova G et al. The neural basis of familial risk and temperamental variation in individuals at high risk of bipolar disorder. Biol Psychiatry 2011; 70: 343-349.
30. Foland LC, Altshuler LL, Bookheimer SY, Eisenberger N, Townsend J, Thompson PM. Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res 2008; 162: 27-37.
31. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord 2000; 2: 237-248.
32. Blumberg HP, Leung HC, Skudlarski P et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry 2003; 60: 601-609.
33. Kronhaus DM, Lawrence NS, Williams AM et al. Stroop performance in bipolar disorder: further evidence for abnormalities in the ventral prefrontal cortex. Bipolar Disord 2006; 8: 28-39.
34. Blumberg HP, Stern E, Ricketts S et al. Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry 1999; 156: 1986-1988.
35. Adler CM, Holland SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disord 2004; 6: 540-549.
36. Chepenik LG, Raffo M, Hampson M et al. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Res 2010; 182: 207-210.
37. Almeida JR, Mechelli A, Hassel S, Versace A, Kupfer DJ, Phillips ML. Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder. Psychiatry Res 2009; 174: 195-201.
38. Versace A, Almeida JRC, Phillips ML. Neuroimaging studies of bipolar and unipolar depression. Strakowski SM ed. The Bipolar BraIntegrating Neuroimaging and Genetics. New York: Oxford University Press, 2012: 125-146.
39. Adler CM, Adams J, DelBello MP et al. Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry 2006; 163: 322-324.
40. Frazier JA, Breeze JL, Papadimitriou G et al. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord 2007; 9: 799-809.
41. Versace A, Ladouceur CD, Romero S et al. Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry 2010; 49: 1249-1259.
42. Strakowski SM, DelBello MP, Zimmerman ME et al. Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. Am J Psychiatry 2002; 159: 1841-1847.
43. Versace A, Almeida JRC, Hassel S et al. Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry 2008; 65: 1041-1052.
44. Marchand WR, Yurgelun-Todd D. Striatal structure and function in mood disorders: a comprehensive review. Bipolar Disord 2010; 12: 764-785.
45. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000; 4: 215-222.
46. Mayberg HS, Liotti M, Brannan SK et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999; 156: 675-682.
47. Strakowski SM, Adler CM, Cerullo MA et al. MRI brain activation in first-episode bipolar mania during a response inhibition task. Early Intervention in Psychiatry 2008; 2: 225-233.
48. Wessa M, Houenou J, Paillère-Martinot ML et al. Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. Am J Psychiatry 2007; 164: 638-646.
49. Marchand WR, Lee JN, Thatcher GW et al. A functional MRI study of a paced motor activation task to evaluate frontal-subcortical circuit function in bipolar depression. Psychiatry Res 2007; 155: 221-230.
50. Wang F, Kalmar JH, He Y et al. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 2009; 66: 516-21.
51. Pavuluri MN, O'Connor MM, Harral EM, Sweeney JA. An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res 2008; 162: 244-255.
52. Gruber SA, Rogowska J, Yurgelun-Todd DA. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord 2004; 82: 191-201.
53. Goodwin FK, Jamison KR. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd Edition. New York: Oxford University Press, 2007.
54. McNamara RK, Nandagopal JJ, Strakowski SM, DelBello MP. Preventative strategies for early-onset bipolar disorder: towards a clinical staging model. CNS Drugs 2010; 24: 983-996.
55. Singh MK, DelBello MP, Chang KD. Neuroimaging studies of bipolar disorder in youth. Strakowski SM ed. The Bipolar BraIntegrating Neuroimaging and Genetics. New York: Oxford University Press, 2012: 103-124.
56. Singh MK, DelBello MP, Stanford K, Strakowski SM. Neuroanatomical characterization of child offspring of parents with bipolar disorder. Journal Am Acad Child Adolesc Psychiatry 2008; 47: 526-531.
57. Ladouceur CD, Almeida JR, Birmaher B et al. Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder? J Am Acad Child Adolesc Psychiatry 2008; 47: 532-539.
58. Botteron KN, Figiel GS, Wetzel MW, Hudziak J, VanEerdewegh M. MRI abnormalities in adolescent bipolar affective disorder. J Am Acad Child Adolesc Psychiaty. 1992; 31: 258-261.
59. Lyoo IK, Lee HK, Jung JH, Noam GG, Renshaw PF. White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders. Compr Psychiatry 2002; 43: 361-368.
60. Caetano SC, Silveira CM, Kaur S et al. Abnormal corpus callosum myelination in pediatric bipolar patients. J Affect Disord 2008; 108: 297-301.
61. Sprooten E, Sussmann JE, Clugston A et al. White matter integrity in individuals at high genetic risk of bipolar disorder. Biol Psychiatry 2011; 70: 350-356.
62. Kafantaris V, Kingsley P, Ardekani B et al. Lower orbital frontal white matter integrity in adolescents with bipolar I disorder. J Am Acad Child Adolesc Psychiatry 2009; 48: 79-86.
63. Barnea-Goraly N, Chang KD, Karchemskiy A, Howe ME, Reiss AL. Limbic and corpus callosum aberrations in adolescents with bipolar disorder: a tract-based spatial statistics analysis. Biol Psychiatry 2009; 66: 238-244.
64. Pfeifer JC, Welge J, Strakowski SM, Adler CM, DelBello MP. Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2008; 47: 1289-1298.
65. Bitter SM, Mills NP, Adler CM, Strakowski SM, DelBello MP. Progression of amygdala volumetric abnormalities in adolescents after their first manic episode. J Am Acad Child Adolesc Psychiatry 2011; 50: 1017-1026.
66. Hallahan B, Newell J, Soares JC et al. Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data. Biol Psychiatry 2011; 69: 326-335.
67. Blumberg HP, Krystal JH, Bansal R et al. Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biol Psychiatry 2006; 59: 611-618.
68. Kalmar JH, Wang F, Spencer L et al. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. J Int Neuropsychol Soc 2009; 15: 476-481.
69. Sanches M, Roberts RL, Sassi RB et al. Developmental abnormalities in striatum in young bipolar patients: a preliminary study. Bipolar Disord 2005; 7: 153-158.
70. Gogtay N, Ordonez A, Herman DH et al. Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness. J Child Psychol Psychiatry 2007; 48: 852-862.
71. Logothetis NK. What we can do and what we cannot do with fMRI. Nature 2008; 453: 869-878.
72. Strakowski SM, DelBello MP, Fleck DE et al. Effects of co-occur ring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania. Arch Gen Psychiatry 2005; 62: 851-858.