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Volumn 22, Issue 5, 2014, Pages 1708-1725

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

(12) Kumar, Nag S a Dullaghan, Edie M b Finlay, B Brett c Gong, Huansheng c Reiner, Neil E c,d Jon Paul Selvam, J a Thorson, Lisa M c Campbell, Sara b Vitko, Nicholas e Richardson, Anthony R e Zoraghi, Roya c Young, Robert N a

a SIMON FRASER UNIVERSITY (Canada)

b Centre for Drug Research and Development (Canada)

c UNIVERSITY OF BRITISH COLUMBIA (Canada)

d UNIVERSITY OF BRITISH COLUMBIA (Canada)

e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE (United States)

Author keywords

Antibacterial; Bis indole; MRSA; Pyruvate kinase

Indexed keywords

2 ACETYLENE INDOLE; 2 IODOINDOLE; 3 4 DIHYDROHAMACANTHIN B; 5 BROMO 1H,1'H 2,20 BIINDOLE; 5,5' BROMO 1H,1'H 2,20 BIINDOLE; 5,5',6 TRIBROMO 1H,1'H 2,20 BIINDOLE; 5,5',6,6' TETRABROMO 1H,1'H 2,20 BIINDOLE; 5,6 BIBROMO 1H,1'H 2,20 BIINDOLE; 5,6',6 TRIBROMO 1H,1'H 2,20 BIINDOLE; 6' BROMO 1H,1'H 2,20 BIINDOLE; 6' BROMO 5 CHLORO 1H,1'H 2,20 BIINDOLE; 6' BROMO 5 FLUORO 1H,1'H 2,20 BIINDOLE; 6,6' DIBROMO 1H,1'H 2,20 BIINDOLE; ANTIINFECTIVE AGENT; BORONIC ACID DERIVATIVE; INDOLE; PYRUVATE KINASE; PYRUVATE KINASE INHIBITOR; UNCLASSIFIED DRUG; VANCOMYCIN;

ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CULTURE OPTIMIZATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; MICROBIOLOGY; STAPHYLOCOCCUS INFECTION;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR STRUCTURE; PYRUVATE KINASE; STAPHYLOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896698945 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.01.020 Document Type: Article

Times cited : (38)

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