Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase

ACS Chemical Biology

Volumn 7, Issue 2, 2012, Pages 350-359

  Axerio Cilies, Peter ^a,c   See, Raymond H ^a   Zoraghi, Roya ^a   Worral, Liam ^a   Lian, Tian ^a   Stoynov, Nikolay ^a   Jiang, Jihong ^a   Kaur, Sukhbir ^a   Jackson, Linda ^a   Gong, Huansheng ^a   Swayze, Rick ^a   Amandoron, Emily ^a   Kumar, Nag S ^d   Moreau, Anne ^d   Hsing, Michael ^a,c   Strynadka, Natalie C ^a   McMaster, William R ^a   Finlay, B Brett ^a,b   Foster, Leonard J ^a   Young, Robert N ^d   Reiner, Neil E ^a   Cherkasov, Artem ^a,c   more..

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c VANCOUVER PROSTATE CENTRE   (Canada)

^d SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; IS 130; IS 134; IS 136; IS 152; IS 165; IS 168; IS 173; IS 176; IS 193; IS 53; IS 63; LIGAND; PHOSPHOTRANSFERASE INHIBITOR; PYRUVATE KINASE; PYRUVATE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION MAPS; PYRUVATE KINASE; SEQUENCE ALIGNMENT; STAPHYLOCOCCAL INFECTIONS;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 84857557642     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb2003576     Document Type: Article

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