Repeated blast exposures cause brain DNA fragmentation in mice

Journal of Neurotrauma

Volumn 31, Issue 5, 2014, Pages 498-504

  Wang, Ying ^a   Arun, Peethambaran ^a   Wei, Yanling ^a   Oguntayo, Samuel ^a   Gharavi, Robert ^a   Valiyaveettil, Manojkumar ^a   Nambiar, Madhusoodana P ^a   Long, Joseph B ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

apoptosis; blast induced neurotrauma; cell free DNA; DNA damage; mitochondria

Indexed keywords

CASPASE 3; CELL DNA; CELL FREE DNA; CYTOCHROME C; DEOXYRIBONUCLEASE I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; EXPLOSION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MULTIPLE TRAUMA; NONHUMAN; PROTEIN SECRETION; RIGHTING REFLEX; SHOCK WAVE; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLAST INJURIES; BRAIN; BRAIN INJURIES; CASPASE 3; DNA FRAGMENTATION; EXPLOSIONS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; UP-REGULATION;

EID: 84896692567     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.3074     Document Type: Article

References (31)

1. Magnuson, J., Leonessa, F., and Ling, G.S. (2012). Neuropathology of explosive blast traumatic brain injury. Curr. Neurol. Neurosci. Rep. 570-579.
2. Ling, G., Bandak, F., Armonda, R., Grant, G., and Ecklund, J. (2009). Explosive blast neurotrauma. J. Neurotrauma 26, 815-825.
3. Ling, G.S., and Ecklund, J.M. (2011). Traumatic brain injury in modern war. Curr. Opin. Anaesthesiol. 24, 124-130.
4. Cernak, I., Merkle, A.C., Koliatsos, V.E., Bilik, J.M., Luong, Q.T., Mahota, T.M., Xu, L, Slack, N., Windle, D., and Ahmed, F.A. (2011). The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiol. Dis. 41, 538-551.
5. Long, J.B., Bentley, T.L., Wessner, K.A., Cerone, C., Sweeney, S., and Bauman, R.A. (2009). Blast overpressure in rats: Recreating a battlefield injury in the laboratory. J. Neurotrauma 26, 827-840.
6. Kamnaksh, A., Kovesdi, E., Kwon, S.K., Wingo, D., Ahmed, F., Grunberg, N.E., Long, J., and Agoston, D.V. (2011). Factors affecting blast traumatic brain injury. J. Neurotrauma 28, 2145-2153.
7. Rubovitch, V., Ten-Bosch, M., Zohar, O., Harrison, C.R., Tempel-Brami, C., Stein, E., Hoffer, B.J., Balaban, C.D., Schreiber, S., Chiu, W.T., and Pick, C.G. (2011). A mouse model of blast-induced mild traumatic brain injury. Exp. Neurol. 232, 280-289.
8. Wang, Y., Wei, Y., Oguntayo, S., Wilkins, W., Arun, P., Valiyaveettil, M., Song, J., Long, J.B., and Nambiar, M.P. (2011). Tightly coupled repetitive blast-induced traumatic brain injury: Development and characterization in mice. J. Neurotrauma 28, 2171-2183.
9. Arun, P., Oguntayo, S., Alamneh, Y., Honnold, C., Wang, Y., Valiyaveettil, M., Long, J.B., and Nambiar, M.P. (2012). Rapid release of tissue enzymes into blood after blast exposure: Potential use as biological dosimeters. PLoS One 7, e33798.
10. Cernak, I. (2010). The importance of systemic response in the pathobiology of blast-induced neurotrauma. Front. Neurol. 1, 151.
11. Valiyaveettil, M., Alamneh, Y., Wang, Y., Arun, P., Oguntayo, S., Wei, Y., Long, J.B., and Nambiar, M.P. (2013). Contribution of systemic factors in the pathophysiology of repeated blast-induced neurotrauma. Neurosci. Lett. 539, 1-6.
12. Campello Yurgel, V., Ikuta, N., Brondani da Rocha, A., Lunge, V.R., Fett Schneider, R., Kazantzi Fonseca, A.S., Grivicich, I., Zanoni, C., and Regner, A. (2007). Role of plasma DNA as a predictive marker of fatal outcome following severe head injury in males. J. Neurotrauma 24, 1172-1181.
13. Lewen, A., Skoglosa, Y., Clausen, F., Marklund, N., Chan, P.H., Lindholm, D., and Hillered, L. (2001). Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury. J. Cereb. Blood Flow Metab. 21, 344-350.
14. Macher, H., Egea-Guerrero, J.J., Revuelto-Rey, J., Gordillo-Escobar, E., Enamorado-Enamorado, J., Boza, A., Rodriguez, A., Molinero, P., Guerrero, J.M., Dominguez-Roldan, J.M., Murillo-Cabezas, F., and Rubio, A. (2012). Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury. Clin. Chim. Acta 414, 12-17.
15. Ohayon, S., Boyko, M., Saad, A., Douvdevani, A., Gruenbaum, B.F., Melamed, I., Shapira, Y., Teichberg, V.I., and Zlotnik, A. (2012). Cell-free DNA as a marker for prediction of brain damage in traumatic brain injury in rats. J. Neurotrauma 29, 261-267.
16. Pun, P.B., Kan, E.M., Salim, A., Li, Z., Ng, KC., Moochhala, S.M., Ling, E.A., Tan, M.H., and Lu, J. (2011). Low level primary blast injury in rodent brain. Front. Neurol. 2, 19.
17. Coppede, F., and Migliore, L. (2009). DNA damage and repair in Alzheimer's disease. Curr. Alzheimer Res. 6, 36-47.
18. Martin, L.J. (2010). Mitochondrial and cell death mechanisms in neurodegenerative diseases. Pharmaceuticals (Basel) 3, 839-915.
19. Santos, R.X., Correia, S.C., Zhu, X., Lee, H.G., Petersen, R.B., Nunomura, A., Smith, M.A., Perry, G., and Moreira, P.I. (2012). Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radic. Res. 46, 565-576.
20. Wang, J., Xiong, S., Xie, C., Markesbery, W.R., and Lovell, M.A. (2005). Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J. Neurochem. 93, 953-962.
21. Swarup, V., Srivastava, A.K., Padma, M.V., and Rajeswari, M.R. (2011). Quantification of circulating plasma DNA in Friedreich's ataxia and spinocerebellar ataxia types 2 and 12. DNA Cell Biol. 30, 389-394.
22. Kwon, S.K., Kovesdi, E., Gyorgy, A.B., Wingo, D., Kamnaksh, A., Walker, J., Long, J.B., and Agoston, D.V. (2011). Stress and traumatic brain injury: A behavioral, proteomics, and histological study. Front. Neurol. 2,12.
23. Goldshtein, H., Hausmann, M.J., and Douvdevani, A. (2009). A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids. Ann. Clin. Biochem. 46, 488-494.
24. Bing-Rong, Z., Song-Liang, J., Xiao, E., Xiang-Fei, L., Bao-Xiang, C., Jie, G., and Dan, L. (2008). Protective effect of the Baicalin against DNA damage induced by ultraviolet B irradiation to mouse epidermis. Photodermatol. Photoimmunol. Photomed. 24, 175-182.
25. Widyarini, S. (2006). Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin. J. Vet. Sci. 7, 217-223.
26. Roos, W.P., and Kaina, B. (2006). DNA damage-induced cell death by apoptosis. Trends Mol. Med. 12, 440-450.
27. Wang, JY. (2001). DNA damage and apoptosis. Cell Death Differ. 8, 1047-1048.
28. Jiang, Y., Guo, C., Vasko, M.R., and Kelley, M.R. (2008). Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons. Cancer Res. 68, 6425-6434.
29. Lan, J., Li, W., Zhang, F., Sun, F.Y., Nagayama, T., O'Horo, C., and Chen, J. (2003). Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion. J. Cereb. Blood Flow Metab. 23, 1324-1339.
30. Li, W., Luo, Y., Zhang, F., Signore, A.P., Gobbel, G.T., Simon, R.P., and Chen, J. (2006). Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway. J. Cereb. Blood Flow Metab. 26, 181-198.
31. Vasko, M.R., Guo, C., Thompson, E.L., and Kelley, M.R. (2011). The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. DNA Repair (Amst.) 10, 942-952.