Cell-free DNA as a marker for prediction of brain damage in traumatic brain injury in rats

Journal of Neurotrauma

Volumn 29, Issue 2, 2012, Pages 261-267

  Ohayon, Sharon ^a   Boyko, Matthew ^a   Saad, Amit ^b   Douvdevani, Amos ^a   Gruenbaum, Benjamin F ^a   Melamed, Israel ^a   Shapira, Yoram ^a   Teichberg, Vivian I ^c   Zlotnik, Alexander ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY OF HAIFA   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

biomarker; brain edema; CFD; neurological performance; TBI

Indexed keywords

BIOLOGICAL MARKER; CELL FREE DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN WATER; BRAIN WEIGHT; CONTROLLED STUDY; DISEASE SEVERITY; MALE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTION; RAT; TRAUMATIC BRAIN INJURY;

ANIMALS; BIOLOGICAL MARKERS; BRAIN DAMAGE, CHRONIC; BRAIN EDEMA; BRAIN INJURIES; CELL-FREE SYSTEM; DISEASE MODELS, ANIMAL; DNA; MALE; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84856420576     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1938     Document Type: Article

References (46)

1. Adams, J.H., Doyle, D., Ford, I., Gennarelli, T.A., Graham, D.I., and McLellan, D.R. (1989). Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology 15, 49-59. (Pubitemid 19188950)
2. Barzo, P., Marmarou, A., Fatouros, P., Corwin, F., and Dunbar, J. (1996). Magnetic resonance imaging-monitored acute blood-brain barrier changes in experimental traumatic brain injury. J. Neurosurg. 85, 1113-1121. (Pubitemid 26396568)
3. Blumbergs, P.C., Jones, N.R., and North, J.B. (1989). Diffuse axonal injury in head trauma. J. Neurol. Neurosurg. Psy-chiatry. 52, 838-841. (Pubitemid 19181340)
4. Blumbergs, P.C., Scott, G., Manavis, J., Wainwright, H., Simp-son, D.A., and McLean, A.J. (1994). Staining of amyloid pre-cursor protein to study axonal damage in mild head injury. Lancet 344, 1055-1056. (Pubitemid 24310039)
5. Blumbergs, P.C., Scott, G., Manavis, J., Wainwright, H., Simp-son, D.A., and McLean, A.J. (1995). Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury. J. Neurotrauma 12, 565-572.
6. Campello Yurgel, V., Ikuta, N., Brondani da Rocha, A., Lunge, V.R., Fett Schneider, R., Kazantzi Fonseca, A.S., Grivicich, I., Zanoni, C., and Regner, A. (2007). Role of plasma DNA as a predictive marker of fatal outcome following severe head injury in males. J. Neurotrauma 24, 1172-1181. (Pubitemid 47106290)
7. Chang, C.P., Chia, R.H., Wu, T.L., Tsao, K.C., Sun, C.F., and Wu, J.T. (2003). Elevated cell-free serum DNA detected in patients with myocardial infarction. Clin. Chim. Acta 327, 95-101. (Pubitemid 35447821)
8. Chen, Y., Constantini, S., Trembovler, V., Weinstock, M., and Shohami, E. (1996). An experimental model of closed head injury in mice: pathophysiology, histopathology, and cogni-tive deficits. J. Neurotrauma 13, 557-568. (Pubitemid 26377854)
9. Gennarelli, T.A. (1994). Animate models of human head injury. J. Neurotrauma 11, 357-368. (Pubitemid 24304688)
10. Goldshtein, H., Hausmann, M.J., and Douvdevani, A. (2009). A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids. Ann. Clin. Biochem. 46, 488-494.
11. Gordon, W.A., Brown, M., Sliwinski, M., Hibbard, M.R., Patti, N., Weiss, M.J., Kalinsky, R., and Sheerer, M. (1998). The en-igma of ''hidden'' traumatic brain injury. J. Head Trauma Rehabil. 13, 39-56. (Pubitemid 29263782)
12. Graham, D.I., Adams, J.H., Nicoll, J.A., Maxwell, W.L., and Gennarelli, T.A. (1995). The nature, distribution and causes of traumatic brain injury. Brain Pathol. 5, 397-406.
13. Hayasaki, K., Marmarou, A., Barzo, P., Fatouros, P., and Cor-win, F. (1997). Detection of brain atrophy following traumatic brain injury using gravimetric techniques. Acta Neurochir. Suppl. 70, 75-77. (Pubitemid 127502056)
14. Ishige, N., Pitts, L.H., Berry, I., Carlson, S.G., Nishimura, M.C., Moseley, M.E., and Weinstein, P.R. (1987). The effect of hyp-oxia on traumatic head injury in rats, alterations in neurologic function, brain edema, and cerebral blood flow. J Cereb. Blood Flow Metab. 7, 759-767. (Pubitemid 18029818)
15. Kawamata, T., Katayama, Y., Maeda, T., Mori, T., Aoyama, N., Kikuchi, T., and Uwahodo, Y. (1997). Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats. Acta Neurochir. Suppl. 70,191-193. (Pubitemid 127502092)
16. Kelly, J.P. (1999). Traumatic brain injury and concussion in sports. JAMA 282, 989- 991. (Pubitemid 29420321)
17. Kochanek, P.M., Marion, D.W., Zhang, W., Schiding, J.K., White, M., Palmer, A.M., Clark, R.S., O'Malley, M.E., Styren, S.D., and Ho, C. (1995). Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12, 1015-1025. (Pubitemid 26044665)
18. Krug, E.G., Sharma, G.K., and Lozano, R. (2000). The global burden of injuries. Am. J. Public Health 90, 523-526. (Pubitemid 30167408)
19. Laurer, H.L., Lenzlinger, P.M., and McIntosh, T.K. (2000). Models of traumatic brain injury. Eur. J. Trauma 26, 95-100.
20. Laurer, H.L., and McIntosh, T.K. (1999). Experimental models of brain trauma. Curr. Opin. Neurol. 12, 715-721. (Pubitemid 30072353)
21. Lo, Y.M., Rainer, T.H., Chan, L.Y., Hjelm, N.M., and Cocks, R.A. (2000). Plasma DNA as a prognostic marker in trauma patients. Clin. Chem. 46, 319-323. (Pubitemid 30152256)
22. Marmarou, A., Tanaka, K., and Shulman, K. (1982). An im-proved gravimetric measure of cerebral edema. J. Neurosurg. 56, 246-253. (Pubitemid 12093798)
23. Maxwell, W.L., Povlishock, J.T., and Graham, D.L. (1997). A mechanistic analysis of nondisruptive axonal injury: a review. J. Neurotrauma 14, 419-440. (Pubitemid 27338081)
24. McIntosh, T.K., Saatman, K.E., Raghupathi, R., Graham, D.I., Smith, D.H., Lee, V.M., and Trojanowski, J.Q. (1998). The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathol. Appl. Neurobiol. 24, 251-267. (Pubitemid 28389121)
25. Menzies, S.A., Hoff, J.T., and Betz, A.L. (1992). Middle cerebral artery occlusion in rats: a neurological and pathologi-cal evaluation of a reproducible model. Neurosurgery 31, 100-107.
26. Mittl, R.L., Grossman, R.I., Hiehle, J.F., Hurst, R.W., Kauder, D.R., Gennarelli, T.A., and Alburger, G.W. (1994). Prevalence of MR evidence of diffuse axonal injury in patients with mild head injury and normal head CT findings. AJNR Am. J. Neuroradiol. 15, 1583-1589. (Pubitemid 24285915)
27. Morganti-Kossmann, M.C., Yan, E., and Bye, N. (2010). Animal models of traumatic brain injury: is there an optimal model to reproduce human brain injury in the laboratory? Injury 41, Suppl. 1, S10-13.
28. Park, D.S., Morris, E.J., Stefanis, L., Troy, C.M., Shelanski, M.L., Geller, H.M., and Greene, L.A. (1998). Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. J. Neurosci. 18, 830- 840. (Pubitemid 28112906)
29. Pierce, J.E., Smith, D.H., Trojanowski, J.Q., and McIntosh, T.K. (1998). Enduring cognitive, neurobehavioral and histopath-ological changes persist for up to one year following severe experimental brain injury in rats. Neuroscience 87, 359- 369. (Pubitemid 28370896)
30. Povlishock, J.T., Buki, A., Koiziumi, H., Stone, J., and Okonkwo, D.O. (1999). Initiating mechanisms involved in the pathobi-ology of traumatically induced axonal injury and interven-tions targeted at blunting their progression. Acta Neurochir. Suppl. 73, 15-20.
31. Povlishock, J.T., Hayes, R.L., Michel, M.E., and McIntosh, T.K. (1994). Workshop on animal models of traumatic brain injury. J. Neurotrauma 11, 723-732.
32. Prieto, R., Gutierrez-Gonzalez, R., Pascual, J.M., Roda, J.M., Cerdan, S., Matias- Guiu, J., and Barcia, J.A. (2009). Experi-mental models of traumatic brain injury [in Spanish]. Neuro-cirugia (Astur). 20, 225-244.
33. Rainer, T.H., Wong, L.K., Lam, W., Yuen, E., Lam, NY., Me-treweli, C., and Lo, Y.M. (2003). Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin. Chem. 49, 562-569. (Pubitemid 36379520)
34. Sbordone, R.J., and Ruff, R.M. (2010). Re-examination of the controversial coexistence of traumatic brain injury and post-traumatic stress disorder: misdiagnosis and self-report mea-sures. Psychol. Inj. Law 3, 63-76.
35. Schneider, G., Fries, P., Wagner-Jochem, D., Thome, D., Laurer, H., Kramann, B., Mautes, A., and Hagen, T. (2002). Patho-physiological changes after traumatic brain injury: compari-son of two experimental animal models by means of MRI. MAGMA 14, 233-241. (Pubitemid 34786974)
36. Shapira, Y., Shohami, E., Sidi, A., Soffer, D., Freeman, S., and Cotev, S. (1988). Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties. Crit. Care Med. 16, 258-265. (Pubitemid 18081907)
37. Shimony, A., Zahger, D., Gilutz, H., Goldstein, H., Orlov, G., Merkin, M., Shalev, A., Ilia, R., and Douvdevani, A. (2010). Cell free DNA detected by a novel method in acute ST-elevation myocardial infarction patients. Acute Card Care 12, 109-111.
38. Shojo, H., Kaneko, Y., Mabuchi, T., Kibayashi, K., Adachi, N., and Borlongan, C.V. (2010) Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following mod-erate fluid percussion injury. Neuroscience 171, 1273-1282.
39. Swarup, V., and Rajeswari, M.R. (2007). Circulating (cell-free) nucleic acids-a promising, non-invasive tool for early detection of several human diseases. FEBS Lett. 581, 795-799. (Pubitemid 46282711)
40. Tang, Y.P., Noda, Y., Hasegawa, T., and Nabeshima, T. (1997a). A concussive-like brain injury model in mice (I): impairment in learning and memory. J. Neurotrauma 14, 851-862. (Pubitemid 28007569)
41. Tang, Y.P., Noda, Y., Hasegawa, T., and Nabeshima, T. (1997b). A concussive-like brain injury model in mice (II): selective neuronal loss in the cortex and hippocampus. J Neurotrauma 14, 863-873.
42. Unterberg, A.W., Stover, J., Kress, B., and Kiening, K.L. (2004). Edema and brain trauma. Neuroscience 129, 1021-1029. (Pubitemid 39556253)
43. Vaz, R., Sarmento, A., Borges, N., Cruz, C., and Azevedo, T. (1998). Experimental traumatic cerebral contusion: morpho-logical study of brain microvessels and characterization of the oedema. Acta Neurochir. (Wien). 140, 76-81. (Pubitemid 28052630)
44. Waxweiler, R.J., Thurman, D., Sniezek, J., Sosin, D., and O'Neil, J. (1995). Monitoring the impact of traumatic brain injury: a review and update. J. Neurotrauma 12, 509-516.
45. Zlotnik, A., Gurevich, B., Cherniavsky, E., Tkachov, S., Matuzani-Ruban, A., Leon, A., Shapira, Y., and Teichberg, V.I. (2008). The contribution of the blood glutamate scaveng-ing activity of pyruvate to its neuroprotective properties in a rat model of closed head injury. Neurochem. Res. 33, 1044-1050.
46. Zlotnik, A., Gurevich, B., Tkachov, S., Maoz, I., Shapira, Y., and Teichberg, V.I. (2007). Brain neuroprotection by scavenging blood glutamate. Exp. Neurol. 203, 213-220. (Pubitemid 44821179)