SCOPUS 정보 검색 플랫폼

Volumn 9, Issue 3, 2014, Pages 580-589

Naphthyridines as novel bet family bromodomain inhibitors

(14) Mirguet, Olivier a,b Lamotte, Yann a Chung, Chun Wa c Bamborough, Paul c Delannée, Delphine a Bouillot, Anne a Gellibert, Françoise a,c Krysa, Gael a Lewis, Antonia c Witherington, Jason c Huet, Pascal a Dudit, Yann a Trottet, Lionel a Nicodeme, Edwige a

a GLAXOSMITHKLINE (France)

b INSTITUT DE RECHERCHES SERVIER (France)

c GLAXOSMITHKLINE (United Kingdom)

Author keywords

BET family bromodomains inhibitors; epigenetic readers; inflammation; naphthyridines

Indexed keywords

1 BENZYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 8 METHOXY 1H IMIDAZO [4,5 C][1,5]NAPHTHYRIDINE 2(3H) ONE; 2 (3,5 DIMETHYLISOXAZOL 4 YL)PYRIDIN 4 AMINE; 4 (BENZYLAMINO) 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXAMIDE; 4 (BENZYLAMINO) 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 4 [(2 ( TERT BUTYL)PHENYL)AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 4 [(2 (TERT BUTYL)PHENYL)AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 4 [(CYCLOHEXYLMETHYL)AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 4 [[2 ( TERT BUTYL)PHENYL]AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 1,6 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 4 [[2 (TERT BUTYL)PHENYL]AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXAMIDE; 5 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXYPYRIDIN 3 AMINE; 6 (3,5 DIMETHYLISOXAZOL 4 YL)PYRIDIN 2 AMINE; 7 (3,5 DIMETHYLISOXAZOL 4 YL) 4 [(2 FLUOROPHENYL)AMINO] 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXAMIDE; 7 (3,5 DIMETHYLISOXAZOL 4 YL) 4 [(2 FLUOROPHENYL)AMINO] 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 4 [[2 (TRIFLUOROMETHOXY) PHENY]AMINO] 1,5 NAPHTHYRIDINE 3 CARBOXAMIDE; 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 4 [[2 (TRIFLUOROMETHOXY) PHENYL]AMINO] 1,5 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (3,5 DIMETHYLISOXAZOL 4 YL) 8 METHOXY 1 [2 (TRIFLUOROMETHOXY)PHENYL] 1H IMIDAZOL[4,5 C][1,5]NAPHTHYRIDINE 2(3H) ONE; ANTIINFLAMMATORY AGENT; BROMODOMAIN AND EXTRA TERMINAL PROTEIN; ETHYL 4 (BENZYLAMINO) 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 4 [(CYCLOHEXYLMETHYL)AMINO] 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 4 [[2 ( TERT BUTYL)PHENYL]AMINO] 7 (3,5 DIMETHYLISOXAZOL 4YL) 1,6 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 4 [[2 (TERT BUTYL)PHENYL]AMINO] 7 (3,5 DIMETHYLISOXAZOL 4YL) 1,8 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 4 [[2 (TERT BUTYL)PHENYL]AMINO] 7 (3,5 DIMETHYLISOXAZOL 4YL) 6 METHOXY 1,5 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 4 OXO 1,4 DIHYDRO 1,6 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 4 [[2 (TRIFLUOROMETHOXY)PHENYL]AMINO] 1,5 NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 7 (3,5 DIMETHYLISOXAZOL 4 YL) 6 METHOXY 4 OXO 1,4 DIHYDRO 1,5 NAPHTHYRIDINE 3 CARBOXYLATE; NAPHTHYRIDINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CELL ACTIVITY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; HISTONE MODIFICATION; INFLAMMATION; ISOMERISM; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; QUANTUM MECHANICS; X RAY CRYSTALLOGRAPHY;

BET FAMILY BROMODOMAINS INHIBITORS; EPIGENETIC READERS; INFLAMMATION; NAPHTHYRIDINES;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHYRIDINES; NUCLEAR PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84896692123 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300259 Document Type: Article

Times cited : (33)

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